DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008] See more...

Aliases for DPEP2 Gene

Aliases for DPEP2 Gene

  • Dipeptidase 2 2 3 4 5
  • EC 3.4.13.19 4 52
  • MBD2 3

External Ids for DPEP2 Gene

Previous GeneCards Identifiers for DPEP2 Gene

  • GC16M067756
  • GC16M067797
  • GC16M066578
  • GC16M068021
  • GC16M053894

Summaries for DPEP2 Gene

Entrez Gene Summary for DPEP2 Gene

  • DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DPEP2 Gene

DPEP2 (Dipeptidase 2) is a Protein Coding gene. Among its related pathways are Arachidonic acid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and metalloexopeptidase activity. An important paralog of this gene is DPEP3.

UniProtKB/Swiss-Prot Summary for DPEP2 Gene

  • Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).

Additional gene information for DPEP2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DPEP2 Gene

Genomics for DPEP2 Gene

GeneHancer (GH) Regulatory Elements for DPEP2 Gene

Promoters and enhancers for DPEP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPEP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DPEP2

Top Transcription factor binding sites by QIAGEN in the DPEP2 gene promoter:
  • CBF(2)
  • CBF-A
  • GATA-2
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • NF-kappaB1
  • NF-kappaB2
  • Nkx2-5

Genomic Locations for DPEP2 Gene

Genomic Locations for DPEP2 Gene
chr16:67,987,390-68,000,611
(GRCh38/hg38)
Size:
13,222 bases
Orientation:
Minus strand
chr16:68,021,293-68,034,489
(GRCh37/hg19)
Size:
13,197 bases
Orientation:
Minus strand

Genomic View for DPEP2 Gene

Genes around DPEP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPEP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPEP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPEP2 Gene

Proteins for DPEP2 Gene

  • Protein details for DPEP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4A9-DPEP2_HUMAN
    Recommended name:
    Dipeptidase 2
    Protein Accession:
    Q9H4A9
    Secondary Accessions:
    • A0A024R6Y5
    • B2RCF8
    • B3KS59
    • I3L248
    • Q6UX92
    • Q8TC95

    Protein attributes for DPEP2 Gene

    Size:
    486 amino acids
    Molecular mass:
    53365 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer; disulfide-linked.
    SequenceCaution:
    • Sequence=AAQ88819.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for DPEP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPEP2 Gene

Selected DME Specific Peptides for DPEP2 Gene

Q9H4A9:
  • PCQTQDRDA
  • APVIFSHS
  • DGHNDLP
  • ELQGVLRGNLLRVFRQ
  • CASYSELELVTS
  • ANVSTVADHFDHI

Post-translational modifications for DPEP2 Gene

  • Glycosylation at Asn176, Asn111, and Asn235
  • Modification sites at PhosphoSitePlus

Domains & Families for DPEP2 Gene

Gene Families for DPEP2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DPEP2 Gene

Blocks:
  • Renal dipeptidase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DPEP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ35565 fis, clone SPLEN2005450, highly similar to Dipeptidase 2 (EC 3.4.13.19) (B3KS59_HUMAN)
  • Dipeptidase 2 (DPEP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H4A9

UniProtKB/Swiss-Prot:

DPEP2_HUMAN :
  • Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
Family:
  • Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
genes like me logo Genes that share domains with DPEP2: view

Function for DPEP2 Gene

Molecular function for DPEP2 Gene

UniProtKB/Swiss-Prot Function:
Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Hydrolysis of dipeptides.; EC=3.4.13.19; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by L-penicillamine.

Enzyme Numbers (IUBMB) for DPEP2 Gene

Phenotypes From GWAS Catalog for DPEP2 Gene

Gene Ontology (GO) - Molecular Function for DPEP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008235 metalloexopeptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008239 dipeptidyl-peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DPEP2: view
genes like me logo Genes that share phenotypes with DPEP2: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPEP2 Gene

Localization for DPEP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPEP2 Gene

Membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPEP2 gene
Compartment Confidence
plasma membrane 2
extracellular 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for DPEP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with DPEP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DPEP2 Gene

Pathways & Interactions for DPEP2 Gene

genes like me logo Genes that share pathways with DPEP2: view

Pathways by source for DPEP2 Gene

Gene Ontology (GO) - Biological Process for DPEP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with DPEP2: view

No data available for SIGNOR curated interactions for DPEP2 Gene

Drugs & Compounds for DPEP2 Gene

(1) Additional Compounds for DPEP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Leukotriene E4
  • (5S-(5R*,6S*(s*),7E,9E,11Z,14Z))-6-((2-amino-2-carboxyethyl)thio)-5-hydroxy-7,9,11,14-eicosatetraenoic acid
  • (7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyeicosa-7,9,11,14-tetraenoate
  • (7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate
  • 5S-Hydroxy,6R-(S-cysteinyl),7E,9E,11Z,14Z-eicosatetraenoic acid
  • (5S-(5R*,6S*(s*),7E,9E,11Z,14Z))-6-((2-amino-2-carboxyethyl)thio)-5-hydroxy-7,9,11,14-eicosatetraenoate
75715-89-8
genes like me logo Genes that share compounds with DPEP2: view

Transcripts for DPEP2 Gene

mRNA/cDNA for DPEP2 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPEP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: -
SP2: -

Relevant External Links for DPEP2 Gene

GeneLoc Exon Structure for
DPEP2

Expression for DPEP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DPEP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPEP2 Gene

This gene is overexpressed in Whole Blood (x33.3) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for DPEP2 Gene

This gene is overexpressed in Serum (51.4) and Plasma (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DPEP2 Gene



Protein tissue co-expression partners for DPEP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DPEP2

SOURCE GeneReport for Unigene cluster for DPEP2 Gene:

Hs.372633

Evidence on tissue expression from TISSUES for DPEP2 Gene

  • Bone marrow(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with DPEP2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPEP2 Gene

Orthologs for DPEP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPEP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPEP2 31 30
  • 99.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DPEP2 30
  • 83.72 (n)
cow
(Bos Taurus)
Mammalia DPEP2 31 30
  • 82.91 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpep2 30
  • 77.19 (n)
mouse
(Mus musculus)
Mammalia Dpep2 17 31 30
  • 75.95 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 53 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 31
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 57 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dpep2 30
  • 57.53 (n)
zebrafish
(Danio rerio)
Actinopterygii DPEP3 31
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG42750 31 30
  • 56.37 (n)
ManyToMany
CG6154 31
  • 41 (a)
ManyToMany
CG5282 31
  • 24 (a)
ManyToMany
CG34420 31
  • 22 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007854 30
  • 54.72 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 54 (a)
ManyToMany
-- 31
  • 47 (a)
ManyToMany
Species where no ortholog for DPEP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPEP2 Gene

ENSEMBL:
Gene Tree for DPEP2 (if available)
TreeFam:
Gene Tree for DPEP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DPEP2: view image

Paralogs for DPEP2 Gene

Paralogs for DPEP2 Gene

(2) SIMAP similar genes for DPEP2 Gene using alignment to 7 proteins:

  • DPEP2_HUMAN
  • B3KS59_HUMAN
  • I3L248_HUMAN
  • I3L348_HUMAN
  • I3L4H3_HUMAN
  • J3KSU4_HUMAN
  • J3QLL2_HUMAN
genes like me logo Genes that share paralogs with DPEP2: view

Variants for DPEP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DPEP2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs1133090 - p.His468Asp
rs255051 - p.Arg201Pro

Additional dbSNP identifiers (rs#s) for DPEP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for DPEP2 Gene

Variant ID Type Subtype PubMed ID
esv2671023 CNV deletion 23128226
esv3638896 CNV loss 21293372
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680

Variation tolerance for DPEP2 Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPEP2 Gene

Human Gene Mutation Database (HGMD)
DPEP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPEP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPEP2 Gene

Disorders for DPEP2 Gene

Additional Disease Information for DPEP2

No disorders were found for DPEP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPEP2 Gene

Publications for DPEP2 Gene

  1. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. (PMID: 18193043) Willer CJ … Abecasis GR (Nature genetics 2008) 3 41 54
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54

Products for DPEP2 Gene

Sources for DPEP2 Gene