External Ids for DPEP2 Gene
Previous GeneCards Identifiers for DPEP2 Gene
DPEP2 belongs to the membrane-bound dipeptidase (EC 188.8.131.52) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]
GeneCards Summary for DPEP2 Gene
DPEP2 (Dipeptidase 2) is a Protein Coding gene. Diseases associated with DPEP2 include Prolidase Deficiency. Among its related pathways are Busulfan Pathway, Pharmacodynamics and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and metalloexopeptidase activity. An important paralog of this gene is DPEP3.
UniProtKB/Swiss-Prot Summary for DPEP2 Gene
Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4). Does not hydrolyze cystinyl-bis-glycine.
Independently of its dipeptidase activity can also modulate macrophage inflammatory response by acting as a regulator of NF-kappaB inflammatory signaling pathway.