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The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript var... See more...
Aliases for DPEP1 Gene
Aliases for DPEP1 Gene
External Ids for DPEP1 Gene
- HGNC: 3002
- Entrez Gene: 1800
- Ensembl: ENSG00000015413
- OMIM: 179780
- UniProtKB: P16444
Previous GeneCards Identifiers for DPEP1 Gene
- GC16P081008
- GC16P090676
- GC16P089390
- GC16P089430
- GC16P088214
- GC16P089679
- GC16P075374
Summaries for DPEP1 Gene
-
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for DPEP1 Gene
DPEP1 (Dipeptidase 1) is a Protein Coding gene. Diseases associated with DPEP1 include Blau Syndrome and Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema. Among its related pathways are Eicosanoid Synthesis and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and dipeptidase activity. An important paralog of this gene is DPEP2.
UniProtKB/Swiss-Prot Summary for DPEP1 Gene
-
Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490, PubMed:6334084, PubMed:31442408). Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (By similarity). Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics (PubMed:6334084).
-
Independently of its dipeptidase activity acts as an adhesion receptor for neutrophils recruitement from bloodstream into inflammed lungs and liver.
Additional gene information for DPEP1 Gene
- HGNC(3002)
- Entrez Gene(1800)
- Ensembl(ENSG00000015413)
- OMIM(179780)
- UniProtKB(P16444)
- Open Targets Platform(ENSG00000015413)
- Search for DPEP1 at DataMed
- Search for DPEP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DPEP1 Gene
Genomics for DPEP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DPEP1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH16J089612 | Promoter/Enhancer | 1 | Ensembl ENCODE CraniofacialAtlas | 600.7 | +0.2 | 181 | 2.1 | PRDM10 ZNF580 BCOR ZNF146 ZNF398 KDM1A ZMYM3 | DPEP1 piR-31439 CHMP1A CDK10 SPIRE2 GAS8-AS1 piR-55985-070 | |
| GH16J089620 | Promoter/Enhancer | 1 | EPDnew Ensembl CraniofacialAtlas | 600.4 | +6.9 | 6906 | 0.8 | CEBPA NRF1 TFAP4 ZFP64 GLIS1 RBPJ | DPEP1 DBNDD1 CHMP1A piR-55985-070 | |
| GH16J089630 | Promoter/Enhancer | 0.7 | EPDnew ENCODE | 600.4 | +16.9 | 16879 | 0.2 | DRAP1 HNF1A | DPEP1 piR-55985-070 piR-50960 CHMP1A | |
| GH16J089621 | Promoter | 0.6 | EPDnew | 600.4 | +8.1 | 8143 | 0.1 | ZIC2 GLIS1 RBPJ | DPEP1 piR-55985-070 CHMP1A | |
| GH16J089613 | Enhancer | 0.3 | Ensembl | 600.7 | -1.2 | -1207 | 0.2 | ZBTB33 | DPEP1 piR-31439 CDK10 hsa-miR-5095-201 CPNE7 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DPEP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DPEP1
- Top Transcription factor binding sites by QIAGEN in the DPEP1 gene promoter:
-
- AP-1
- AP-4
- c-Myc
- E47
- En-1
- LUN-1
- Max
- NF-1
Genomic Locations for DPEP1 Gene
Genomic Locations for DPEP1 Gene
- chr16:89,613,308-89,641,540
- (GRCh38/hg38)
- Size:
- 28,233 bases
- Orientation:
- Plus strand
- chr16:89,679,716-89,704,839
- (GRCh37/hg19)
- Size:
- 25,124 bases
- Orientation:
- Plus strand
Genomic View for DPEP1 Gene
Genes around DPEP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.3 by HGNC
- 16q24.3 by Entrez Gene
- 16q24.3 by Ensembl
DPEP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DPEP1 Gene
Proteins for DPEP1 Gene
-
Protein details for DPEP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P16444-DPEP1_HUMAN
- Recommended name:
- Dipeptidase 1
- Protein Accession:
- P16444
- D3DX80
- Q96AK2
Protein attributes for DPEP1 Gene
- Size:
- 411 amino acids
- Molecular mass:
- 45674 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homodimer; disulfide-linked.
Protein Expression for DPEP1 Gene
Selected DME Specific Peptides for DPEP1 Gene
- P16444:
-
- RNVPDDVL
- APVIFSHS
- DGHNDLP
- IDSSLGVLR
- CNTPWADNWLVD
- VGGQFWS
- GLEDVSKYPDL
- THTNIPKL
- SLVMVNF
- WWLWPLVAVC
Post-translational modifications for DPEP1 Gene
Other Protein References for DPEP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences Renal Dipeptidase / DPEP1 Antibody (LS-A8265) and Renal Dipeptidase / DPEP1 Antibody (LS-A109972)
- Novus Biologicals Antibodies for DPEP1
- Invitrogen Antibodies for DPEP1 (AFLGC-DPEP1)
- Sino Biological Antibodies for DPEP1
Protein Products
- G Biosciences Human Dipeptidase 1/DPEP1, Lyophilized
-
OriGene Purified Proteins for DPEP1
- Search Origene for MassSpec and Protein Over-expression Lysates for DPEP1
- Origene Custom Protein Services for DPEP1
- Sino Biological Recombinant Proteins for DPEP1
- Sino Biological Cell Lysates for DPEP1
-
ProSci Proteins for DPEP1
Assay Products
Domains & Families for DPEP1 Gene
Gene Families for DPEP1 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- FDA approved drug targets
- Predicted intracellular proteins
Protein Domains for DPEP1 Gene
- InterPro:
- Blocks:
-
- Renal dipeptidase
- ProtoNet:
Suggested Antigen Peptide Sequences for DPEP1 Gene
- GenScript: Design optimal peptide antigens:
-
- Renal dipeptidase (DPEP1_HUMAN)
- DPEP1 protein (Q6I9V1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P16444UniProtKB/Swiss-Prot:
DPEP1_HUMAN :- Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
- Family:
-
- Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
Function for DPEP1 Gene
Molecular function for DPEP1 Gene
- UniProtKB/Swiss-Prot Function:
- Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490, PubMed:6334084, PubMed:31442408). Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (By similarity). Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics (PubMed:6334084).
- UniProtKB/Swiss-Prot Function:
- Independently of its dipeptidase activity acts as an adhesion receptor for neutrophils recruitement from bloodstream into inflammed lungs and liver.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid; Xref=Rhea:RHEA:48940, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869, ChEBI:CHEBI:77460; EC=3.4.13.19; Evidence={ECO:0000255|PROSITE-ProRule:PRU10073, ECO:0000269|PubMed:2303490};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + leukotriene D4 = glycine + leukotriene E4; Xref=Rhea:RHEA:48616, ChEBI:CHEBI:15377, ChEBI:CHEBI:57305, ChEBI:CHEBI:57462, ChEBI:CHEBI:63166; Evidence={ECO:0000269|PubMed:2303490};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a beta-lactam + H2O = a substituted beta-amino acid; Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627, ChEBI:CHEBI:140347; EC=3.5.2.6; Evidence={ECO:0000269|PubMed:6334084};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=2 H2O + L-cystine-bis-glycine = 2 glycine + L-cystine; Xref=Rhea:RHEA:60520, ChEBI:CHEBI:15377, ChEBI:CHEBI:35491, ChEBI:CHEBI:57305, ChEBI:CHEBI:143812; Evidence={ECO:0000250|UniProtKB:P31428};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine; Xref=Rhea:RHEA:62704, ChEBI:CHEBI:15377, ChEBI:CHEBI:57305, ChEBI:CHEBI:145925, ChEBI:CHEBI:145926; Evidence={ECO:0000269|PubMed:2303490, ECO:0000269|PubMed:31442408, ECO:0000269|PubMed:6334084};.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in n colorectal cancers.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=10.9 uM for imipenem {ECO:0000269|PubMed:6334084}; Vmax=44.5 umol/min/mg enzyme with imipenem as substrate {ECO:0000269|PubMed:6334084};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by L-penicillamine (PubMed:31442408). Beta-lactamase activity is inhibited by cilastatin (PubMed:6334084, PubMed:31442408).
- GENATLAS Biochemistry:
- dipeptidase 1 (renal)
Enzyme Numbers (IUBMB) for DPEP1 Gene
Phenotypes From GWAS Catalog for DPEP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008235 | metalloexopeptidase activity | TAS | 2303490 |
| GO:0008237 | metallopeptidase activity | IEA | -- |
| GO:0008239 | dipeptidyl-peptidase activity | IEA | -- |
Phenotypes for DPEP1 Gene
- MGI mutant phenotypes for DPEP1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DPEP1:
Animal Models for DPEP1 Gene
- MGI Knock Outs for DPEP1:
-
- Dpep1 Dpep1<tm1Mwl>
Animal Model Products
-
Taconic Biosciences Mouse Models for DPEP1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DPEP1 - Select products 50% OFF >
- * DPEP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DPEP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DPEP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for DPEP1
miRNA for DPEP1 Gene
- miRTarBase miRNAs that target DPEP1
-
- hsa-miR-195-5p (MIRT007219)
- hsa-miR-615-3p (MIRT040325)
- hsa-miR-10a-5p (MIRT047606)
- hsa-miR-25-3p (MIRT050283)
- hsa-miR-129-5p (MIRT290618)
- hsa-miR-8055 (MIRT678991)
- hsa-miR-3672 (MIRT678992)
- hsa-miR-6864-3p (MIRT678993)
- hsa-miR-5007-5p (MIRT678994)
- hsa-miR-4524a-3p (MIRT678995)
- hsa-miR-4797-5p (MIRT678996)
- hsa-miR-5089-5p (MIRT690057)
- hsa-miR-7151-3p (MIRT690058)
- hsa-miR-5095 (MIRT690059)
- hsa-miR-5589-5p (MIRT690060)
- hsa-miR-4731-5p (MIRT690061)
- hsa-miR-6778-3p (MIRT690062)
- hsa-miR-4707-3p (MIRT690063)
- hsa-miR-6506-5p (MIRT690064)
- hsa-miR-619-5p (MIRT690065)
- hsa-miR-18a-3p (MIRT690066)
- hsa-miR-324-3p (MIRT690067)
- hsa-miR-1913 (MIRT690068)
- hsa-miR-150-5p (MIRT690069)
- hsa-miR-7107-5p (MIRT690070)
- hsa-miR-1234-3p (MIRT690071)
- hsa-miR-6814-5p (MIRT690072)
- hsa-miR-4761-5p (MIRT690073)
- hsa-miR-6504-3p (MIRT690074)
- hsa-miR-4735-3p (MIRT690075)
- hsa-miR-18b-5p (MIRT690076)
- hsa-miR-18a-5p (MIRT690077)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DPEP1
- Browse OriGene Inhibitory RNA Products For DPEP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPEP1
Clone Products
- Applied Biological Materials (abm): Clones for DPEP1 - Select products 50% OFF >
- * DPEP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206443
- MR206443
- MR206443L3
- MR206443L4
- RC201964
- RC201964L1
- RC201964L2
- RC201964L3
- RC201964L4
- RC225645
- RC225645L1
- RC225645L2
- RC225645L3
- RC225645L4
- RG201964
- RG225645
- RR213655
- RR213655L3
- RR213655L4
- MR206443L3V
- MR206443L4V
- RC201964L1V
- RC201964L2V
- RC201964L3V
- RC201964L4V
- RC225645L1V
- RC225645L2V
- RC225645L3V
- RC225645L4V
- RR213655L3V
- RR213655L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DPEP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DPEP1
Cell Line Products
-
Horizon Cell Lines for DPEP1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPEP1 Gene
Localization for DPEP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DPEP1 Gene
- Apical cell membrane. Lipid-anchor, GPI-anchor. Cell projection, microvillus membrane. Lipid-anchor, GPI-anchor. Note=Brush border membrane. {ECO:0000250 UniProtKB:P31429}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| nucleus | 4 |
| mitochondrion | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Cell Junctions (3)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | ISS | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005886 | plasma membrane | IBA,TAS | 20031578 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016324 | apical plasma membrane | IEA | -- |
Pathways & Interactions for DPEP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Arachidonic acid metabolism | ||
| 2 | Metabolism |
.40
|
|
| 3 | Busulfan Pathway, Pharmacodynamics | ||
| 4 | Aflatoxin activation and detoxification | ||
| 5 | Cytochrome P450 - arranged by substrate type | ||
Pathways by source for DPEP1 Gene
2 BioSystems pathways for DPEP1 Gene
6 Reactome pathways for DPEP1 Gene
1 PharmGKB pathway for DPEP1 Gene
Interacting Proteins for DPEP1 Gene
Selected Interacting proteins:
P16444-DPEP1_HUMAN
ENSP00000376807
for DPEP1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for DPEP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006691 | leukotriene metabolic process | TAS | -- |
| GO:0006749 | glutathione metabolic process | TAS | 20031578 |
| GO:0006751 | glutathione catabolic process | ISS | -- |
No data available for SIGNOR curated interactions for DPEP1 Gene
Drugs & Compounds for DPEP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cilastatin | Approved, Investigational | Pharma | Inhibitor, Inhibition, Target, inhibitor | 41 | ||
| Imipenem | Approved | Pharma | Enzyme, substrate | 78 | ||
| Zinc | Approved, Investigational | Pharma | 1594 | |||
| Doripenem | Approved, Investigational | Pharma | Enzyme, substrate | 31 | ||
| Clavulanate | Approved, Vet_approved | Pharma | inhibitor | 231 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- G Biosciences Human Dipeptidase 1/DPEP1, Lyophilized
Transcripts for DPEP1 Gene
mRNA/cDNA for DPEP1 Gene
- 2 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000570029 525 nts (view in UCSC)
- ENST00000565249 1165 nts (view in UCSC)
- ENST00000564281 1772 nts (view in UCSC)
- ENST00000568281 482 nts (view in UCSC)
- ENST00000393092 1734 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DPEP1 - Select products 50% OFF >
- * DPEP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DPEP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DPEP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for DPEP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DPEP1
- Browse OriGene Inhibitory RNA Products For DPEP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPEP1
Clone Products
- Applied Biological Materials (abm): Clones for DPEP1 - Select products 50% OFF >
- * DPEP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206443
- MR206443
- MR206443L3
- MR206443L4
- RC201964
- RC201964L1
- RC201964L2
- RC201964L3
- RC201964L4
- RC225645
- RC225645L1
- RC225645L2
- RC225645L3
- RC225645L4
- RG201964
- RG225645
- RR213655
- RR213655L3
- RR213655L4
- MR206443L3V
- MR206443L4V
- RC201964L1V
- RC201964L2V
- RC201964L3V
- RC201964L4V
- RC225645L1V
- RC225645L2V
- RC225645L3V
- RC225645L4V
- RR213655L3V
- RR213655L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DPEP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DPEP1
Relevant External Links for DPEP1 Gene
- GeneLoc Exon Structure for
- DPEP1
Expression for DPEP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Proximal Tubule Cells Proximal Tubule
- Glomerulus
- Glomerular Tuft
- Proximal Tubule
- Epithelial Tubule
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Epithelial Cells
- Proximal Tubule Cells Proximal Tubule
- Intestine (Gastrointestinal Tract)
-
Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for DPEP1 Gene
This gene is overexpressed in Small Intestine - Terminal Ileum (x19.2), Pancreas (x15.8), and Kidney - Cortex (x12.0).
This gene is overexpressed in Urine (22.3), Ovary (18.4), Testis (13.1), and Kidney (11.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPEP1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DPEP1
SOURCE GeneReport for Unigene cluster for DPEP1 Gene:
Hs.109mRNA Expression by UniProt/SwissProt for DPEP1 Gene:
P16444-DPEP1_HUMAN
Tissue specificity:
Expressed in lung and kidneys.
Evidence on tissue expression from TISSUES for DPEP1 Gene
- Eye(5)
- Kidney(4.7)
- Intestine(4.7)
- Liver(4.7)
- Muscle(3.4)
- Lung(3.4)
- Nervous system(3.3)
- Spleen(3.3)
- Heart(3)
- Pancreas(2.9)
Primer Products
-
OriGene qPCR primer pairs for DPEP1
-
OriGene qPCR primer pairs and template standards for DPEP1
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPEP1 Gene
Orthologs for DPEP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DPEP1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DPEP1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DPEP1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dpep1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Dpep1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | DPEP1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | DPEP1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | DPEP1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | DPEP1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dpep1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | dpep1 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG6154 30 31 32 |
|
ManyToMany | |
| CG5917 32 |
|
|
|||
| CG5282 31 32 |
|
ManyToMany | |||
| CG34420 31 |
|
ManyToMany | |||
| CG42750 31 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002634 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU09538 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC3A11.10c 30 |
|
- Species where no ortholog for DPEP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for DPEP1 Gene
- ENSEMBL:
- Gene Tree for DPEP1 (if available)
- TreeFam:
- Gene Tree for DPEP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DPEP1: view image
Paralogs for DPEP1 Gene
Variants for DPEP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DPEP1 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1043397364 | A colorectal cancer sample | p.Arg246His | |||
| rs1126464 | -. - | p.Glu351Lysp.Glu351Gln |
Residual Variation Intolerance Score:
62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.59;
65.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DPEP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DPEP1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPEP1 Gene
Disorders for DPEP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| blau syndrome |
|
|
| dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema |
|
|
| retinitis pigmentosa 7 |
|
|
| colorectal cancer |
|
|
| miller-dieker lissencephaly syndrome |
|
|
Search DPEP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DPEP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for DPEP1 Gene
Publications for DPEP1 Gene
- Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis. (PMID: 12144777) Nitanai Y … Tsujimoto M (Journal of molecular biology 2002) 3 4 23
- Gene structural analysis and expression of human renal dipeptidase. (PMID: 7764673) Satoh S … Kohsaka M (Biotechnology progress 1994) 3 4 23
- Importance of Glu-125 in the catalytic activity of human renal dipeptidase. (PMID: 8097406) Adachi H … Tsujimoto M (Biochimica et biophysica acta 1993) 3 4 23
- Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme. (PMID: 2137335) Hooper NM … Turner AJ (The Biochemical journal 1990) 3 4 23
- Primary structure of human microsomal dipeptidase deduced from molecular cloning. (PMID: 2303490) Adachi H … Nakazato H (The Journal of biological chemistry 1990) 3 4 23
ExternalLinks
Products for DPEP1 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for DPEP1
- Search Origene for MassSpec and Protein Over-expression Lysates for DPEP1
- Origene Custom Protein Services for DPEP1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DPEP1
- Browse OriGene Inhibitory RNA Products For DPEP1
- OriGene qPCR primer pairs for DPEP1
- OriGene qPCR primer pairs and template standards for DPEP1
- OriGene CRISPR knockouts for DPEP1
- MG206443
- MR206443
- MR206443L3
- MR206443L4
- RC201964
- RC201964L1
- RC201964L2
- RC201964L3
- RC201964L4
- RC225645
- RC225645L1
- RC225645L2
- RC225645L3
- RC225645L4
- RG201964
- RG225645
- RR213655
- RR213655L3
- RR213655L4
- MR206443L3V
- MR206443L4V
- RC201964L1V
- RC201964L2V
- RC201964L3V
- RC201964L4V
- RC225645L1V
- RC225645L2V
- RC225645L3V
- RC225645L4V
- RR213655L3V
- RR213655L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DPEP1
- Sino Biological Human cDNA Clone for DPEP1
- Sino Biological Recombinant Proteins for DPEP1
- Sino Biological Cell Lysates for DPEP1
- Sino Biological Antibodies for DPEP1
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for DPEP1
- Novus Biologicals proteins and lysates for DPEP1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for DPEP1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for DPEP1 (AFLGC-DPEP1)
- VectorBuilder Custom and pre-made DNA vectors for DPEP1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for DPEP1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for DPEP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for DPEP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for DPEP1
- antibodies-online: Show 15 available DPEP1 Antibodies ranked by validation data
- Compare Top DPEP1 Antibodies
- antibodies-online: Show 18 available DPEP1 Elisa Kits ranked by validation data
- Compare Top DPEP1 Elisa Kits
- antibodies-online: Show 11 available DPEP1 Proteins ranked by validation data
- Compare Top DPEP1 Proteins
- Search for DPEP1 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for DPEP1
- Horizon Cell Lines for DPEP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DPEP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DPEP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DPEP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DPEP1
Sources for DPEP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB