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Aliases for DPEP1 Gene

Aliases for DPEP1 Gene

  • Dipeptidase 1 2 3 5
  • Microsomal Dipeptidase 3 4
  • Dipeptidase 1 (Renal) 2 3
  • Dehydropeptidase-I 3 4
  • Renal Dipeptidase 3 4
  • EC 4 56
  • HRDP 3 4
  • RDP 3 4
  • MDP 3 4
  • Testicular Tissue Protein Li 57 3
  • MBD1 3

External Ids for DPEP1 Gene

Previous GeneCards Identifiers for DPEP1 Gene

  • GC16P081008
  • GC16P090676
  • GC16P089390
  • GC16P089430
  • GC16P088214
  • GC16P089679
  • GC16P075374

Summaries for DPEP1 Gene

Entrez Gene Summary for DPEP1 Gene

  • The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for DPEP1 Gene

DPEP1 (Dipeptidase 1) is a Protein Coding gene. Among its related pathways are Arachidonic acid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and dipeptidase activity. An important paralog of this gene is DPEP2.

UniProtKB/Swiss-Prot for DPEP1 Gene

  • Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.

Gene Wiki entry for DPEP1 Gene

Additional gene information for DPEP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPEP1 Gene

Genomics for DPEP1 Gene

GeneHancer (GH) Regulatory Elements for DPEP1 Gene

Promoters and enhancers for DPEP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I089630 Promoter/Enhancer 0.9 EPDnew ENCODE 550.4 +16.9 16879 0.2 DRAP1 HNF1A DPEP1 PIR44959
GH16I089620 Promoter 0.7 EPDnew 550.4 +7.2 7216 0.1 TFAP4 GLIS1 NRF1 DPEP1 PIR44959
GH16I089612 Enhancer 0.5 ENCODE 550.8 +0.2 181 2.1 BCOR ZNF146 ZNF580 ZMYM3 PRDM10 ZNF398 KDM1A DPEP1 PIR32438 CHMP1A CDK10 SPIRE2 GAS8-AS1 PIR44959
GH16I089686 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.6 +74.0 74003 2.5 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF207 CDK10 LINC02166 DPEP1 VPS9D1 ZNF276 FANCA PIR59284
GH16I088661 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 6.1 -950.2 -950202 2.6 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 POLR2B E2F8 SNAI3-AS1 MVD ZNF778 ZC3H18 ANKRD11 ENSG00000259877 CTU2 KLHDC4 BANP LINC00304
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DPEP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPEP1 gene promoter:

Genomic Locations for DPEP1 Gene

Genomic Locations for DPEP1 Gene
27,555 bases
Plus strand

Genomic View for DPEP1 Gene

Genes around DPEP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPEP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPEP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPEP1 Gene

Proteins for DPEP1 Gene

  • Protein details for DPEP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dipeptidase 1
    Protein Accession:
    Secondary Accessions:
    • D3DX80
    • Q96AK2

    Protein attributes for DPEP1 Gene

    411 amino acids
    Molecular mass:
    45674 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for DPEP1 Gene

neXtProt entry for DPEP1 Gene

Selected DME Specific Peptides for DPEP1 Gene


Post-translational modifications for DPEP1 Gene

  • Glycosylation at posLast=5757, posLast=279279, posLast=332332, and posLast=358358
  • Modification sites at PhosphoSitePlus

Domains & Families for DPEP1 Gene

Gene Families for DPEP1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted secreted proteins

Protein Domains for DPEP1 Gene

Suggested Antigen Peptide Sequences for DPEP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
  • Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
genes like me logo Genes that share domains with DPEP1: view

Function for DPEP1 Gene

Molecular function for DPEP1 Gene

GENATLAS Biochemistry:
dipeptidase 1 (renal)
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of dipeptides.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by L-penicillamine.
UniProtKB/Swiss-Prot Function:
Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.

Enzyme Numbers (IUBMB) for DPEP1 Gene

Phenotypes From GWAS Catalog for DPEP1 Gene

Gene Ontology (GO) - Molecular Function for DPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008233 peptidase activity IEA --
GO:0008235 metalloexopeptidase activity TAS 2303490
GO:0008237 metallopeptidase activity IEA --
GO:0008239 dipeptidyl-peptidase activity IEA --
genes like me logo Genes that share ontologies with DPEP1: view
genes like me logo Genes that share phenotypes with DPEP1: view

Animal Models for DPEP1 Gene

MGI Knock Outs for DPEP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for DPEP1

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPEP1 Gene

Localization for DPEP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPEP1 Gene

Apical cell membrane; Lipid-anchor, GPI-anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI-anchor. Note=Brush border membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPEP1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS --
GO:0005634 nucleus IDA --
GO:0005886 plasma membrane TAS 20031578
GO:0016020 membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with DPEP1: view

Pathways & Interactions for DPEP1 Gene

genes like me logo Genes that share pathways with DPEP1: view

Pathways by source for DPEP1 Gene

Interacting Proteins for DPEP1 Gene

Gene Ontology (GO) - Biological Process for DPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006691 leukotriene metabolic process TAS --
GO:0006749 glutathione metabolic process TAS 20031578
GO:0006805 xenobiotic metabolic process TAS --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with DPEP1: view

No data available for SIGNOR curated interactions for DPEP1 Gene

Drugs & Compounds for DPEP1 Gene

(17) Drugs for DPEP1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cilastatin Approved, Investigational Pharma Inhibition, Inhibitor, Target, inhibitor 34
Zinc Approved, Investigational Pharma 2430
Doripenem Approved, Investigational Pharma Enzyme, substrate 0

(13) Additional Compounds for DPEP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DPEP1: view

Transcripts for DPEP1 Gene

Unigene Clusters for DPEP1 Gene

Dipeptidase 1 (renal):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPEP1 Gene

No ASD Table

Relevant External Links for DPEP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPEP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPEP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPEP1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x19.2), Pancreas (x15.8), and Kidney - Cortex (x12.0).

Protein differential expression in normal tissues from HIPED for DPEP1 Gene

This gene is overexpressed in Urine (22.3), Ovary (18.4), Testis (13.1), and Kidney (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DPEP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DPEP1 Gene:


SOURCE GeneReport for Unigene cluster for DPEP1 Gene:


Evidence on tissue expression from TISSUES for DPEP1 Gene

  • Eye(5)
  • Intestine(4.7)
  • Kidney(4.7)
  • Liver(4.6)
  • Lung(3.2)
  • Muscle(2.9)
  • Spleen(2.9)
  • Nervous system(2.9)
  • Pancreas(2.6)
  • Heart(2.4)
genes like me logo Genes that share expression patterns with DPEP1: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPEP1 Gene

Orthologs for DPEP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DPEP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DPEP1 34
  • 95 (a)
(Bos Taurus)
Mammalia DPEP1 33 34
  • 84.1 (n)
(Canis familiaris)
Mammalia DPEP1 33 34
  • 82.03 (n)
(Rattus norvegicus)
Mammalia Dpep1 33
  • 77.42 (n)
(Mus musculus)
Mammalia Dpep1 33 16 34
  • 76.6 (n)
(Monodelphis domestica)
Mammalia DPEP1 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia DPEP1 34
  • 64 (a)
(Gallus gallus)
Aves DPEP1 33 34
  • 71.32 (n)
(Anolis carolinensis)
Reptilia DPEP1 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dpep1 33
  • 61.43 (n)
(Danio rerio)
Actinopterygii dpep1 33 34
  • 61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6154 35 33 34
  • 57.63 (n)
CG5917 35
  • 44 (a)
CG5282 35 34
  • 28 (a)
CG34420 34
  • 19 (a)
CG42750 34
  • 14 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002634 33
  • 57.18 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09538 33
  • 54.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
-- 34
  • 50 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC3A11.10c 33
  • 47.73 (n)
Species where no ortholog for DPEP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPEP1 Gene

Gene Tree for DPEP1 (if available)
Gene Tree for DPEP1 (if available)

Paralogs for DPEP1 Gene

Paralogs for DPEP1 Gene

(2) SIMAP similar genes for DPEP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DPEP1: view

Variants for DPEP1 Gene

Sequence variations from dbSNP and Humsavar for DPEP1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1043397364 colorectal cancer sample 89,637,349(+) G/A/T coding_sequence_variant, missense_variant
rs1000025790 -- 89,631,314(+) C/T intron_variant
rs1000124588 -- 89,633,856(+) C/G/T intron_variant
rs1000132061 -- 89,632,208(+) C/T intron_variant
rs1000177967 -- 89,631,799(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DPEP1 Gene

Variant ID Type Subtype PubMed ID
dgv1388n106 CNV deletion 24896259
esv1242032 CNV insertion 17803354
esv1355826 CNV insertion 17803354
esv24216 CNV loss 19812545
esv2676847 CNV deletion 23128226
esv2715182 CNV deletion 23290073
esv2715183 CNV deletion 23290073
esv2715184 CNV deletion 23290073
esv2715186 CNV deletion 23290073
esv2715187 CNV deletion 23290073
esv2715188 CNV deletion 23290073
esv2762221 CNV gain+loss 21179565
esv3639589 CNV loss 21293372
esv3639590 CNV loss 21293372
esv7562 CNV gain 19470904
nsv103438 CNV deletion 16902084
nsv1057351 CNV loss 25217958
nsv1063483 CNV gain 25217958
nsv1066382 CNV gain 25217958
nsv1071350 CNV deletion 25765185
nsv1071351 CNV deletion 25765185
nsv1123085 CNV deletion 24896259
nsv1141743 CNV deletion 24896259
nsv1149554 CNV insertion 26484159
nsv1929 CNV insertion 18451855
nsv1930 CNV insertion 18451855
nsv428331 CNV gain+loss 18775914
nsv482951 CNV loss 15286789
nsv509639 CNV insertion 20534489
nsv573738 CNV loss 21841781
nsv573739 CNV gain 21841781
nsv952078 CNV deletion 24416366

Variation tolerance for DPEP1 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPEP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPEP1 Gene

Disorders for DPEP1 Gene

Additional Disease Information for DPEP1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DPEP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPEP1 Gene

Publications for DPEP1 Gene

  1. Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis. (PMID: 12144777) Nitanai Y … Tsujimoto M (Journal of molecular biology 2002) 3 4 22 58
  2. Gene structural analysis and expression of human renal dipeptidase. (PMID: 7764673) Satoh S … Kohsaka M (Biotechnology progress 1994) 3 4 22 58
  3. Importance of Glu-125 in the catalytic activity of human renal dipeptidase. (PMID: 8097406) Adachi H … Tsujimoto M (Biochimica et biophysica acta 1993) 3 4 22 58
  4. Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme. (PMID: 2137335) Hooper NM … Turner AJ (The Biochemical journal 1990) 3 4 22 58
  5. Primary structure of human microsomal dipeptidase deduced from molecular cloning. (PMID: 2303490) Adachi H … Nakazato H (The Journal of biological chemistry 1990) 3 4 22 58

Products for DPEP1 Gene

Sources for DPEP1 Gene

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