Aliases for DPEP1 Gene
External Ids for DPEP1 Gene
Previous GeneCards Identifiers for DPEP1 Gene
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. [provided by RefSeq, Dec 2020]
GeneCards Summary for DPEP1 Gene
DPEP1 (Dipeptidase 1) is a Protein Coding gene. Diseases associated with DPEP1 include Blau Syndrome and Glutamate-Cysteine Ligase Deficiency. Among its related pathways are Busulfan Pathway, Pharmacodynamics and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and dipeptidase activity. An important paralog of this gene is DPEP2.
UniProtKB/Swiss-Prot Summary for DPEP1 Gene
Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed:2303490, PubMed:6334084, PubMed:31442408). Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (By similarity). Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics (PubMed:6334084).
Independently of its dipeptidase activity acts as an adhesion receptor for neutrophils recruitement from bloodstream into inflammed lungs and liver.