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Aliases for DPCR1 Gene

Aliases for DPCR1 Gene

  • Diffuse Panbronchiolitis Critical Region 1 2 3 5
  • C6orf37 3 4
  • PBLT 3 4
  • Diffuse Panbronchiolitis Critical Region Protein 1 3

External Ids for DPCR1 Gene

Previous GeneCards Identifiers for DPCR1 Gene

  • GC06P030975
  • GC06P030689
  • GC06P031025
  • GC06P031026
  • GC06P030908
  • GC06P030941
  • GC06P030944
  • GC06P031075
  • GC06P031087

Summaries for DPCR1 Gene

GeneCards Summary for DPCR1 Gene

DPCR1 (Diffuse Panbronchiolitis Critical Region 1) is a Protein Coding gene. Diseases associated with DPCR1 include Panbronchiolitis, Diffuse.

Additional gene information for DPCR1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPCR1 Gene

Genomics for DPCR1 Gene

GeneHancer (GH) Regulatory Elements for DPCR1 Gene

Promoters and enhancers for DPCR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I030939 Promoter/Enhancer 1 EPDnew ENCODE 550.4 +6.1 6105 1.5 KLF1 ATF1 CREB1 CBFA2T3 NFE2 ZKSCAN1 DPCR1 VARS2 MICA-AS1 ATP6V1G2 TRIM10 SFTA2
GH06I030934 Enhancer 0.7 ENCODE dbSUPER 550.8 +0.6 627 0.9 SREBF1 NFIC IKZF1 ZNF10 SCRT2 CEBPB CEBPG DPCR1 VARS2 HCG27 SFTA2
GH06I030933 Enhancer 0.4 FANTOM5 dbSUPER 550.8 -1.1 -1053 0.1 ENSG00000252761 DPCR1 VARS2 DDR1 SFTA2
GH06I030879 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.1 -50.1 -50140 9.2 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143 FOS DDR1 VARS2 HLA-C PSORS1C1 GNL1 PSORS1C3 SFTA2 HCG18 IER3 FLOT1
GH06I030875 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -57.7 -57703 3.5 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B ZNF2 YY1 POLR2B ZNF766 DDR1 DDR1-AS1 VARS2 DDX39B LSM2 TRIM39 GTF2H4 PPP1R10 LY6G5B MDC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DPCR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DPCR1 gene promoter:

Genomic Locations for DPCR1 Gene

Genomic Locations for DPCR1 Gene
chr6:30,934,523-30,954,221
(GRCh38/hg38)
Size:
19,699 bases
Orientation:
Plus strand
chr6:30,908,749-30,921,998
(GRCh37/hg19)

Genomic View for DPCR1 Gene

Genes around DPCR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPCR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for DPCR1 Gene

  • Protein details for DPCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MIW9-DPCR1_HUMAN
    Recommended name:
    Diffuse panbronchiolitis critical region protein 1
    Protein Accession:
    Q3MIW9
    Secondary Accessions:
    • C9IZC0
    • Q658M7
    • Q8WYN2

    Protein attributes for DPCR1 Gene

    Size:
    517 amino acids
    Molecular mass:
    56347 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH56248.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI18455.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DPCR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPCR1 Gene

Post-translational modifications for DPCR1 Gene

  • Glycosylation at posLast=8888, Asn124, and Asn338
  • Modification sites at PhosphoSitePlus

Other Protein References for DPCR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DPCR1 Gene

Domains & Families for DPCR1 Gene

Gene Families for DPCR1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for DPCR1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DPCR1: view

No data available for UniProtKB/Swiss-Prot for DPCR1 Gene

Function for DPCR1 Gene

Phenotypes From GWAS Catalog for DPCR1 Gene

genes like me logo Genes that share phenotypes with DPCR1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPCR1 Gene

Localization for DPCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPCR1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPCR1 gene
Compartment Confidence
plasma membrane 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DPCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DPCR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DPCR1 Gene

Pathways & Interactions for DPCR1 Gene

SuperPathways for DPCR1 Gene

No Data Available

Interacting Proteins for DPCR1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000417182%0d%0a9606.ENSP00000242261%0d%0a9606.ENSP00000269305%0d%0a
Selected Interacting proteins: ENSP00000417182 Q3MIW9-DPCR1_HUMAN for DPCR1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for DPCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with DPCR1: view

No data available for Pathways by source and SIGNOR curated interactions for DPCR1 Gene

Drugs & Compounds for DPCR1 Gene

No Compound Related Data Available

Transcripts for DPCR1 Gene

mRNA/cDNA for DPCR1 Gene

Unigene Clusters for DPCR1 Gene

Diffuse panbronchiolitis critical region 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPCR1 Gene

No ASD Table

Relevant External Links for DPCR1 Gene

GeneLoc Exon Structure for
DPCR1
ECgene alternative splicing isoforms for
DPCR1

Expression for DPCR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPCR1 Gene

mRNA differential expression in normal tissues according to GTEx for DPCR1 Gene

This gene is overexpressed in Stomach (x42.3) and Esophagus - Mucosa (x5.9).

Protein differential expression in normal tissues from HIPED for DPCR1 Gene

This gene is overexpressed in Stomach (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DPCR1 Gene



Protein tissue co-expression partners for DPCR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DPCR1 Gene:

DPCR1

SOURCE GeneReport for Unigene cluster for DPCR1 Gene:

Hs.631993

mRNA Expression by UniProt/SwissProt for DPCR1 Gene:

Q3MIW9-DPCR1_HUMAN
Tissue specificity: Detected in lung, esophagus, stomach, rectum, skin, cervix, testis, kidney, uterus and small intestine.

Evidence on tissue expression from TISSUES for DPCR1 Gene

  • Stomach(3.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DPCR1 Gene

Germ Layers:
  • endoderm
Systems:
  • immune
  • nervous
  • respiratory
Regions:
Head and neck:
  • epiglottis
  • larynx
  • neck
Thorax:
  • bronchus
  • lung
genes like me logo Genes that share expression patterns with DPCR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DPCR1 Gene

Orthologs for DPCR1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DPCR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPCR1 34
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102152456 33
  • 64.92 (n)
DPCR1 34
  • 37 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpcr1 33 16 34
  • 61.07 (n)
rat
(Rattus norvegicus)
Mammalia Dpcr1 33
  • 59.5 (n)
Species where no ortholog for DPCR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DPCR1 Gene

ENSEMBL:
Gene Tree for DPCR1 (if available)
TreeFam:
Gene Tree for DPCR1 (if available)

Paralogs for DPCR1 Gene

No data available for Paralogs for DPCR1 Gene

Variants for DPCR1 Gene

Sequence variations from dbSNP and Humsavar for DPCR1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000221734 -- 30,941,889(+) A/T intron_variant
rs1000631747 -- 30,952,726(+) G/T intron_variant
rs1000696070 -- 30,944,030(+) T/C intron_variant
rs1001103911 -- 30,947,837(+) C/T intron_variant
rs1001154652 -- 30,948,278(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DPCR1 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
esv3608518 CNV gain 21293372
nsv1031677 CNV gain 25217958
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv462744 CNV loss 19166990
nsv525438 CNV gain 19592680
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv601483 CNV loss 21841781
nsv601484 CNV loss 21841781
nsv823473 CNV loss 20364138

Variation tolerance for DPCR1 Gene

Gene Damage Index Score: 8.39; 85.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPCR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPCR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPCR1 Gene

Disorders for DPCR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DPCR1 Gene - From: OMIM and Orphanet

Disorder Aliases PubMed IDs
panbronchiolitis, diffuse
  • dpb
- elite association - COSMIC cancer census association via MalaCards
Search DPCR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DPCR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DPCR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPCR1 Gene

Publications for DPCR1 Gene

  1. Identification of novel candidate genes in the diffuse panbronchiolitis critical region of the class I human MHC. (PMID: 12185533) Matsuzaka Y … Inoko H (Immunogenetics 2002) 2 3 4 58
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  3. Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J … NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) (PLoS genetics 2009) 3 44 58
  4. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PMID: 16702430) Shiina T … Bahram S (Genetics 2006) 3 4 58
  5. Fine localization of a major disease-susceptibility locus for diffuse panbronchiolitis. (PMID: 10677310) Keicho N … Kudoh S (American journal of human genetics 2000) 2 3 58

Products for DPCR1 Gene

Sources for DPCR1 Gene

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