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Aliases for DPCD Gene

Aliases for DPCD Gene

  • Deleted In Primary Ciliary Dyskinesia Homolog (Mouse) 2 3 5
  • Deleted In A Mouse Model Of Primary Ciliary Dyskinesia 3
  • RP11-529I10.4 3
  • Protein DPCD 3

External Ids for DPCD Gene

Previous GeneCards Identifiers for DPCD Gene

  • GC10U900371
  • GC10P103014
  • GC10P103338
  • GC10P096978

Summaries for DPCD Gene

Entrez Gene Summary for DPCD Gene

  • This gene in mouse encodes a protein that may be involved in the generation and maintenance of ciliated cells. In mouse, expression of this gene increases during ciliated cell differentiation, and disruption of this gene has been linked to primary ciliary dyskinesia. [provided by RefSeq, Jul 2016]

GeneCards Summary for DPCD Gene

DPCD (Deleted In Primary Ciliary Dyskinesia Homolog (Mouse)) is a Protein Coding gene. Diseases associated with DPCD include Split-Hand/Foot Malformation 3.

UniProtKB/Swiss-Prot for DPCD Gene

  • May play a role in the formation or function of ciliated cells.

Additional gene information for DPCD Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPCD Gene

Genomics for DPCD Gene

GeneHancer (GH) Regulatory Elements for DPCD Gene

Promoters and enhancers for DPCD Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J101586 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.4 +17.5 17479 2.4 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 E2F8 ZNF143 POLL DPCD GC10P101487
GH10J101569 Promoter/Enhancer 1.4 Ensembl ENCODE 650.7 -0.1 -94 1.4 ARID4B SIN3A ZNF2 GLIS2 ZNF213 ZNF143 ZNF207 KLF7 RUNX3 KLF13 DPCD LZTS2 PPRC1 BTRC PIR58090 GC10P101487
GH10J101485 Enhancer 1.7 VISTA UCNEbase Ensembl ENCODE 10.8 -84.5 -84507 1.6 PKNOX1 FOXA2 ARNT FEZF1 ZNF2 YY1 ZNF121 ZNF213 RXRA TSHZ1 GC10P101487 RNU2-43P DPCD TLX1 POLL KCNIP2-AS1 MFSD13A GC10M101454 BTRC
GH10J101616 Enhancer 0.8 ENCODE 16.1 +46.9 46948 1.2 HDGF BCOR CTCF SMAD1 MAX ZMYM3 STAT5A EBF1 ZFHX2 EGR1 DPCD POLL FGF8 BTRC RNU6-1165P MIR3158-2 FBXW4
GH10J102009 Enhancer 1.2 Ensembl ENCODE dbSUPER 9 +439.4 439441 0.4 ELF3 ARID4B SIN3A ZNF2 IRF4 ZSCAN9 RAD21 RFX5 SLC30A9 SCRT2 KCNIP2 ARMH3 HPS6 KCNIP2-AS1 OGA FGF8 POLL DPCD ENSG00000222430
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DPCD on UCSC Golden Path with GeneCards custom track

Genomic Locations for DPCD Gene

Genomic Locations for DPCD Gene
39,109 bases
Plus strand
39,109 bases
Plus strand

Genomic View for DPCD Gene

Genes around DPCD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPCD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPCD Gene

Proteins for DPCD Gene

  • Protein details for DPCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein DPCD
    Protein Accession:
    Secondary Accessions:
    • A8K289
    • Q6QNL3
    • Q8N5R1
    • Q9UFY6

    Protein attributes for DPCD Gene

    203 amino acids
    Molecular mass:
    23240 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DPCD Gene

Post-translational modifications for DPCD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DPCD Gene

Domains & Families for DPCD Gene

Gene Families for DPCD Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DPCD Gene


Suggested Antigen Peptide Sequences for DPCD Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DPCD family.
  • Belongs to the DPCD family.
genes like me logo Genes that share domains with DPCD: view

Function for DPCD Gene

Molecular function for DPCD Gene

UniProtKB/Swiss-Prot Function:
May play a role in the formation or function of ciliated cells.

Gene Ontology (GO) - Molecular Function for DPCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with DPCD: view
genes like me logo Genes that share phenotypes with DPCD: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DPCD Gene

Localization for DPCD Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPCD gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DPCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
genes like me logo Genes that share ontologies with DPCD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DPCD Gene

Pathways & Interactions for DPCD Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement IEA --
GO:0007283 spermatogenesis IEA --
GO:0007368 determination of left/right symmetry IEA --
GO:0021591 ventricular system development IEA --
GO:0021670 lateral ventricle development IEA --
genes like me logo Genes that share ontologies with DPCD: view

No data available for Pathways by source and SIGNOR curated interactions for DPCD Gene

Drugs & Compounds for DPCD Gene

No Compound Related Data Available

Transcripts for DPCD Gene

Unigene Clusters for DPCD Gene

Deleted in primary ciliary dyskinesia homolog (mouse):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPCD Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for DPCD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPCD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPCD Gene

mRNA differential expression in normal tissues according to GTEx for DPCD Gene

This gene is overexpressed in Testis (x5.9).

Protein differential expression in normal tissues from HIPED for DPCD Gene

This gene is overexpressed in Testis (13.3), Ovary (8.4), and Fetal heart (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DPCD Gene

Protein tissue co-expression partners for DPCD Gene

NURSA nuclear receptor signaling pathways regulating expression of DPCD Gene:


SOURCE GeneReport for Unigene cluster for DPCD Gene:


mRNA Expression by UniProt/SwissProt for DPCD Gene:

Tissue specificity: Highly expressed in the testis. Weakly expressed in pancreas, skeletal muscle and heart. Expression increases during ciliated cell differentiation.

Evidence on tissue expression from TISSUES for DPCD Gene

  • Kidney(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with DPCD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPCD Gene

Orthologs for DPCD Gene

This gene was present in the common ancestor of animals.

Orthologs for DPCD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DPCD 34 33
  • 94.25 (n)
(Canis familiaris)
Mammalia DPCD 34 33
  • 90.15 (n)
(Bos Taurus)
Mammalia DPCD 34 33
  • 88.01 (n)
(Mus musculus)
Mammalia Dpcd 16 34 33
  • 86.54 (n)
(Monodelphis domestica)
Mammalia DPCD 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia DPCD 34
  • 76 (a)
(Gallus gallus)
Aves DPCD 34 33
  • 73.07 (n)
(Anolis carolinensis)
Reptilia DPCD 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dpcd 33
  • 66.17 (n)
Str.10966 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8292 33
(Danio rerio)
Actinopterygii dpcd 34 33
  • 61.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13901 34 33
  • 51.1 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012517 33
  • 45.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1143 34
  • 49 (a)
Species where no ortholog for DPCD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPCD Gene

Gene Tree for DPCD (if available)
Gene Tree for DPCD (if available)
Evolutionary constrained regions (ECRs) for DPCD: view image

Paralogs for DPCD Gene

No data available for Paralogs for DPCD Gene

Variants for DPCD Gene

Sequence variations from dbSNP and Humsavar for DPCD Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs386352299 uncertain-significance, not provided 101,588,347(+) C/T coding_sequence_variant, missense_variant
rs1000129686 -- 101,593,160(+) G/A intron_variant
rs1000153970 -- 101,607,599(+) T/C intron_variant
rs1000163331 -- 101,593,209(+) C/T intron_variant
rs1000182354 -- 101,606,128(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DPCD Gene

Variant ID Type Subtype PubMed ID
esv23858 CNV loss 19812545
esv2677024 CNV deletion 23128226
esv2750847 CNV gain 17911159
esv3624382 CNV gain 21293372
esv3624385 CNV loss 21293372
nsv1053934 CNV gain 25217958
nsv526529 CNV loss 19592680
nsv527185 CNV loss 19592680

Variation tolerance for DPCD Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DPCD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPCD Gene

Disorders for DPCD Gene

MalaCards: The human disease database

(1) MalaCards diseases for DPCD Gene - From: DISEASES

Disorder Aliases PubMed IDs
split-hand/foot malformation 3
  • shfm3
- elite association - COSMIC cancer census association via MalaCards
Search DPCD in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DPCD

genes like me logo Genes that share disorders with DPCD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPCD Gene

Publications for DPCD Gene

  1. Investigation of the possible role of a novel gene, DPCD, in primary ciliary dyskinesia. (PMID: 14630615) Zariwala M … Ostrowski LE (American journal of respiratory cell and molecular biology 2004) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein. (PMID: 28561026) Cloutier P … Coulombe B (Nature communications 2017) 3 58
  4. BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E … Raught B (Molecular & cellular proteomics : MCP 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for DPCD Gene

Sources for DPCD Gene

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