Aliases for DOT1L Gene
External Ids for DOT1L Gene
Previous GeneCards Identifiers for DOT1L Gene
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
GeneCards Summary for DOT1L Gene
DOT1L (DOT1 Like Histone Lysine Methyltransferase) is a Protein Coding gene. Diseases associated with DOT1L include Leukemia, Acute Myeloid. Among its related pathways are Chromatin Regulation / Acetylation and Lysine degradation. Gene Ontology (GO) annotations related to this gene include transcription factor binding and histone methyltransferase activity.
UniProtKB/Swiss-Prot for DOT1L Gene
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190).
Lysine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the lysine residues on histones, particularly histones H3 and H4. The dysregulation of this methylation is critical in the development of cancer.