Aliases for DOK5 Gene
External Ids for DOK5 Gene
Previous HGNC Symbols for DOK5 Gene
Previous GeneCards Identifiers for DOK5 Gene
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]
GeneCards Summary for DOK5 Gene
DOK5 (Docking Protein 5) is a Protein Coding gene. Diseases associated with DOK5 include Malignant Pheochromocytoma. Among its related pathways are Signaling events regulated by Ret tyrosine kinase and Developmental Biology. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor and insulin receptor binding. An important paralog of this gene is DOK6.
UniProtKB/Swiss-Prot Summary for DOK5 Gene
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.