Aliases for DOK3 Gene

Aliases for DOK3 Gene

  • Docking Protein 3 2 3 4 5
  • Downstream Of Tyrosine Kinase 3 3 4
  • Dok-Like Protein 3
  • FLJ22570 2
  • DOKL 3
  • DOK3 5

External Ids for DOK3 Gene

Previous GeneCards Identifiers for DOK3 Gene

  • GC00U916977
  • GC05M176861
  • GC05M176928
  • GC05M171849

Summaries for DOK3 Gene

GeneCards Summary for DOK3 Gene

DOK3 (Docking Protein 3) is a Protein Coding gene. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and GDNF-Family Ligands and Receptor Interactions. Gene Ontology (GO) annotations related to this gene include insulin receptor binding. An important paralog of this gene is DOK1.

UniProtKB/Swiss-Prot Summary for DOK3 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).

Gene Wiki entry for DOK3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DOK3 Gene

Genomics for DOK3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DOK3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DOK3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DOK3

Top Transcription factor binding sites by QIAGEN in the DOK3 gene promoter:
  • AP-1
  • E2F
  • IRF-1
  • STAT3

Genomic Locations for DOK3 Gene

Genomic Locations for DOK3 Gene
chr5:177,501,904-177,511,274
(GRCh38/hg38)
Size:
9,371 bases
Orientation:
Minus strand
chr5:176,928,905-176,938,275
(GRCh37/hg19)
Size:
9,371 bases
Orientation:
Minus strand

Genomic View for DOK3 Gene

Genes around DOK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOK3 Gene

Proteins for DOK3 Gene

  • Protein details for DOK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L591-DOK3_HUMAN
    Recommended name:
    Docking protein 3
    Protein Accession:
    Q7L591
    Secondary Accessions:
    • E9PAT0
    • H7BXS0
    • Q8N864
    • Q9BQB3
    • Q9H666

    Protein attributes for DOK3 Gene

    Size:
    496 amino acids
    Molecular mass:
    53288 Da
    Quaternary structure:
    • On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL1 through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP (By similarity).

    Alternative splice isoforms for DOK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOK3 Gene

Post-translational modifications for DOK3 Gene

  • Constitutively tyrosine-phosphorylated.
  • On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DOK3 Gene

Domains & Families for DOK3 Gene

Gene Families for DOK3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DOK3 Gene

InterPro:
Blocks:
  • Pleckstrin-like
ProtoNet:

Suggested Antigen Peptide Sequences for DOK3 Gene

GenScript: Design optimal peptide antigens:
  • Downstream of tyrosine kinase 3 (DOK3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7L591

UniProtKB/Swiss-Prot:

DOK3_HUMAN :
  • PTB domain mediates receptor interaction.
  • Belongs to the DOK family. Type A subfamily.
Domain:
  • PTB domain mediates receptor interaction.
Family:
  • Belongs to the DOK family. Type A subfamily.
genes like me logo Genes that share domains with DOK3: view

Function for DOK3 Gene

Molecular function for DOK3 Gene

UniProtKB/Swiss-Prot Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).

Phenotypes From GWAS Catalog for DOK3 Gene

Gene Ontology (GO) - Molecular Function for DOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17290227
genes like me logo Genes that share ontologies with DOK3: view
genes like me logo Genes that share phenotypes with DOK3: view

Animal Models for DOK3 Gene

MGI Knock Outs for DOK3:

Animal Model Products

CRISPR Products

miRNA for DOK3 Gene

miRTarBase miRNAs that target DOK3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DOK3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOK3 Gene

Localization for DOK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOK3 Gene

Cytoplasm. Cell membrane. Peripheral membrane protein. Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOK3 gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for DOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0030667 secretory granule membrane TAS --
GO:0101003 ficolin-1-rich granule membrane TAS --
genes like me logo Genes that share ontologies with DOK3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DOK3 Gene

Pathways & Interactions for DOK3 Gene

PathCards logo

SuperPathways for DOK3 Gene

genes like me logo Genes that share pathways with DOK3: view

Pathways by source for DOK3 Gene

1 Sino Biological pathway for DOK3 Gene
3 Reactome pathways for DOK3 Gene
1 Qiagen pathway for DOK3 Gene
  • GDNF-Family Ligands and Receptor Interactions

Gene Ontology (GO) - Biological Process for DOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007265 Ras protein signal transduction IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with DOK3: view

No data available for SIGNOR curated interactions for DOK3 Gene

Drugs & Compounds for DOK3 Gene

No Compound Related Data Available

Transcripts for DOK3 Gene

mRNA/cDNA for DOK3 Gene

14 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DOK3

Alternative Splicing Database (ASD) splice patterns (SP) for DOK3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - -
SP8: - - - - -
SP9: - - - -
SP10: - -
SP11: - - - -
SP12: - - -
SP13:

Relevant External Links for DOK3 Gene

GeneLoc Exon Structure for
DOK3

Expression for DOK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DOK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Tonsil (Hematopoietic System)

mRNA differential expression in normal tissues according to GTEx for DOK3 Gene

This gene is overexpressed in Whole Blood (x35.0) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for DOK3 Gene

This gene is overexpressed in Lavage (25.9), Peripheral blood mononuclear cells (17.1), Platelet (10.3), and Stomach (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DOK3 Gene



Protein tissue co-expression partners for DOK3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DOK3

SOURCE GeneReport for Unigene cluster for DOK3 Gene:

Hs.720849

mRNA Expression by UniProt/SwissProt for DOK3 Gene:

Q7L591-DOK3_HUMAN
Tissue specificity: Expressed in spleen.

Evidence on tissue expression from TISSUES for DOK3 Gene

  • Blood(4.7)
  • Intestine(4.4)
  • Liver(4.3)
  • Bone marrow(2.6)
  • Spleen(2.4)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with DOK3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DOK3 Gene

Orthologs for DOK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK3 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia DOK3 30 31
  • 82.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DOK3 30 31
  • 82.25 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dok3 30 17 31
  • 79.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dok3 30
  • 79.24 (n)
Oppossum
(Monodelphis domestica)
Mammalia DOK3 31
  • 62 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DOK3 31
  • 50 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DOK3 30 31
  • 60.02 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DOK3 31
  • 40 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CABZ01072950.1 31
  • 42 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Dok 31
  • 13 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4936 31
  • 20 (a)
OneToMany
Species where no ortholog for DOK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DOK3 Gene

ENSEMBL:
Gene Tree for DOK3 (if available)
TreeFam:
Gene Tree for DOK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DOK3: view image

Paralogs for DOK3 Gene

Paralogs for DOK3 Gene

(2) SIMAP similar genes for DOK3 Gene using alignment to 8 proteins:

  • DOK3_HUMAN
  • D6R951_HUMAN
  • D6R977_HUMAN
  • D6RAM3_HUMAN
  • D6RAV2_HUMAN
  • D6RAZ9_HUMAN
  • D6RC22_HUMAN
  • D6RF29_HUMAN
genes like me logo Genes that share paralogs with DOK3: view

Variants for DOK3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DOK3 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs3749728 - p.Arg12Pro
rs41275297 - p.Gly22Arg

Additional dbSNP identifiers (rs#s) for DOK3 Gene

Structural Variations from Database of Genomic Variants (DGV) for DOK3 Gene

Variant ID Type Subtype PubMed ID
nsv1161311 CNV duplication 26073780

Variation tolerance for DOK3 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DOK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOK3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOK3 Gene

Disorders for DOK3 Gene

No disorders were found for DOK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOK3 Gene

Publications for DOK3 Gene

  1. DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PMID: 12595900) Favre C … Nunès JA (Genes and immunity 2003) 2 3 4
  2. Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions. (PMID: 19682241) Senis YA … García A (Journal of thrombosis and haemostasis : JTH 2009) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling. (PMID: 10733577) Lemay S … Veillette A (Molecular and cellular biology 2000) 2 3

Products for DOK3 Gene

  • Signalway Proteins for DOK3

Sources for DOK3 Gene