Aliases for DOK2 Gene
External Ids for DOK2 Gene
Previous GeneCards Identifiers for DOK2 Gene
The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for DOK2 Gene
DOK2 (Docking Protein 2) is a Protein Coding gene. Diseases associated with DOK2 include Chronic Myelomonocytic Leukemia. Among its related pathways are Immune response IL-23 signaling pathway and G-protein signaling M-RAS regulation pathway. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor and transmembrane receptor protein tyrosine kinase adaptor activity. An important paralog of this gene is DOK1.
UniProtKB/Swiss-Prot Summary for DOK2 Gene
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).