Aliases for DOK1 Gene
External Ids for DOK1 Gene
Previous GeneCards Identifiers for DOK1 Gene
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
GeneCards Summary for DOK1 Gene
DOK1 (Docking Protein 1) is a Protein Coding gene. Diseases associated with DOK1 include Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema and Leukemia, Chronic Myeloid. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and B cell receptor signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor and insulin receptor binding. An important paralog of this gene is DOK2.
UniProtKB/Swiss-Prot Summary for DOK1 Gene
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.