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Aliases for DOHH Gene

Aliases for DOHH Gene

  • Deoxyhypusine Hydroxylase 2 3 5
  • HEAT-Like (PBS Lyase) Repeat Containing 1 2 3
  • Deoxyhypusine Hydroxylase/Monooxygenase 2 3
  • HEAT-Like Repeat-Containing Protein 1 3 4
  • Deoxyhypusine Monooxygenase 3 4
  • Deoxyhypusine Dioxygenase 3 4
  • EC 4 56
  • HLRC1 3 4
  • HDOHH 3 4

External Ids for DOHH Gene

Previous HGNC Symbols for DOHH Gene

  • HLRC1

Previous GeneCards Identifiers for DOHH Gene

  • GC19M003443
  • GC19M003256

Summaries for DOHH Gene

Entrez Gene Summary for DOHH Gene

  • This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]

GeneCards Summary for DOHH Gene

DOHH (Deoxyhypusine Hydroxylase) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Gamma carboxylation, hypusine formation and arylsulfatase activation. Gene Ontology (GO) annotations related to this gene include binding and deoxyhypusine monooxygenase activity.

UniProtKB/Swiss-Prot for DOHH Gene

  • Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Additional gene information for DOHH Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOHH Gene

Genomics for DOHH Gene

GeneHancer (GH) Regulatory Elements for DOHH Gene

Promoters and enhancers for DOHH Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I003499 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 564.5 +5.3 5291 1.8 HDGF CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 DOHH GC19P003503 PIR53349 ENSG00000267030 CACTIN-AS1 CACTIN CCDC94 ZNF77 APBA3 ENSG00000267769
GH19I003502 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 13.1 +3.0 2983 0.7 FOXA2 SAP130 TEAD4 TAL1 IRF9 ZNF664 TCF12 CTBP1 ZNF316 POLR2A GC19P003503 DOHH TLE2 FZR1 S1PR4
GH19I003484 Enhancer 0.8 FANTOM5 10.4 +20.8 20803 0.4 BCOR CTCF ZNF76 ZMYM3 ZNF384 ZBTB7B RAD21 ZFHX2 PATZ1 VEZF1 ENSG00000284638 CACTIN ZNF77 CCDC94 DOHH CACTIN-AS1 LOC105372246 GC19P003497
GH19I003386 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.8 +117.3 117337 4.2 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 TCF12 ATF7 RXRA APBA3 CACTIN-AS1 ENSG00000267139 NFIC SMIM24 DOHH ENSG00000279599
GH19I003345 Enhancer 1.1 Ensembl ENCODE dbSUPER 5.3 +159.2 159192 1.7 MAX RAD21 YY1 ZFHX2 ZNF740 RXRA REST MNT GABPA NR2F2 DOHH ENSG00000280103 NFIC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DOHH on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DOHH gene promoter:

Genomic Locations for DOHH Gene

Genomic Locations for DOHH Gene
15,098 bases
Minus strand

Genomic View for DOHH Gene

Genes around DOHH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOHH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOHH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOHH Gene

Proteins for DOHH Gene

  • Protein details for DOHH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Deoxyhypusine hydroxylase
    Protein Accession:
    Secondary Accessions:
    • O75265

    Protein attributes for DOHH Gene

    302 amino acids
    Molecular mass:
    32904 Da
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DOHH Gene

neXtProt entry for DOHH Gene

Selected DME Specific Peptides for DOHH Gene


Post-translational modifications for DOHH Gene

  • Ubiquitination at posLast=1818
  • Modification sites at PhosphoSitePlus

Other Protein References for DOHH Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DOHH Gene

Gene Families for DOHH Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DOHH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the deoxyhypusine hydroxylase family.
  • Belongs to the deoxyhypusine hydroxylase family.
genes like me logo Genes that share domains with DOHH: view

Function for DOHH Gene

Molecular function for DOHH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[eIF5A]-deoxyhypusine + AH(2) + O(2) = [eIF5A]-hypusine + A + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Enzyme Numbers (IUBMB) for DOHH Gene

Gene Ontology (GO) - Molecular Function for DOHH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17213197
GO:0016491 oxidoreductase activity IEA --
GO:0019135 deoxyhypusine monooxygenase activity EXP,IMP 16371467
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DOHH: view
genes like me logo Genes that share phenotypes with DOHH: view

Animal Models for DOHH Gene

MGI Knock Outs for DOHH:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOHH Gene

Localization for DOHH Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOHH gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DOHH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DOHH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOHH Gene

Pathways & Interactions for DOHH Gene

genes like me logo Genes that share pathways with DOHH: view

UniProtKB/Swiss-Prot Q9BU89-DOHH_HUMAN

  • Pathway: Protein modification; eIF5A hypusination.

Interacting Proteins for DOHH Gene

Gene Ontology (GO) - Biological Process for DOHH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DOHH: view

No data available for SIGNOR curated interactions for DOHH Gene

Drugs & Compounds for DOHH Gene

(2) Drugs for DOHH Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for DOHH Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • N(6)-(4-Aminobutyl)-L-lysine
  • N(6)-(4-Aminobutyl)lysine
genes like me logo Genes that share compounds with DOHH: view

Transcripts for DOHH Gene

mRNA/cDNA for DOHH Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(105) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DOHH Gene

Deoxyhypusine hydroxylase/monooxygenase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOHH Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -

Relevant External Links for DOHH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DOHH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DOHH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DOHH Gene

This gene is overexpressed in Bone (25.5) and Heart (25.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DOHH Gene

NURSA nuclear receptor signaling pathways regulating expression of DOHH Gene:


SOURCE GeneReport for Unigene cluster for DOHH Gene:


Evidence on tissue expression from TISSUES for DOHH Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with DOHH: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOHH Gene

Orthologs for DOHH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DOHH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DOHH 33 34
  • 98.68 (n)
(Canis familiaris)
Mammalia LOC485060 33
  • 88.82 (n)
  • 86 (a)
(Bos Taurus)
Mammalia DOHH 33 34
  • 85.51 (n)
(Mus musculus)
Mammalia Dohh 33 16 34
  • 80.62 (n)
(Rattus norvegicus)
Mammalia Dohh 33
  • 78.18 (n)
(Ornithorhynchus anatinus)
Mammalia DOHH 34
  • 76 (a)
(Monodelphis domestica)
Mammalia DOHH 34
  • 57 (a)
(Gallus gallus)
Aves DOHH 33 34
  • 74.61 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145112 33
  • 63.59 (n)
Str.7532 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8013 33
(Danio rerio)
Actinopterygii dohh 33 34
  • 63 (n)
wufb33c04 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11146 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002129 33
  • 62.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta nero 33 34
  • 61.62 (n)
(Caenorhabditis elegans)
Secernentea dohh-1 33 34
  • 55.44 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR426C 33
  • 58.12 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LIA1 33 34
  • 50.98 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B14080g 33
  • 50.61 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G58180 33
  • 50.9 (n)
(Oryza sativa)
Liliopsida Os12g0626100 33
  • 52.35 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05252 33
  • 56.26 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mmd1 33
  • 47.37 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
Species where no ortholog for DOHH was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DOHH Gene

Gene Tree for DOHH (if available)
Gene Tree for DOHH (if available)

Paralogs for DOHH Gene

No data available for Paralogs for DOHH Gene

Variants for DOHH Gene

Sequence variations from dbSNP and Humsavar for DOHH Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000117459 -- 3,490,724(-) G/A downstream_transcript_variant
rs1000287739 -- 3,493,479(-) A/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000504124 -- 3,501,736(-) A/G upstream_transcript_variant
rs1002030480 -- 3,498,406(-) A/T intron_variant
rs1002221408 -- 3,492,366(-) C/G/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for DOHH Gene

Variant ID Type Subtype PubMed ID
nsv470114 CNV loss 18288195
nsv526602 CNV loss 19592680
nsv953948 CNV deletion 24416366

Variation tolerance for DOHH Gene

Gene Damage Index Score: 0.82; 17.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DOHH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOHH Gene

Disorders for DOHH Gene

Additional Disease Information for DOHH

No disorders were found for DOHH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOHH Gene

Publications for DOHH Gene

  1. Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. (PMID: 16371467) Park JH … Park MH (Proceedings of the National Academy of Sciences of the United States of America 2006) 2 3 4 58
  2. Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected]. (PMID: 16533814) Kim YS … Park MH (The Journal of biological chemistry 2006) 2 3 4 58
  3. Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O2 with a nonheme diiron center. (PMID: 19706422) Vu VV … Que L (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 58
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DOHH Gene

Sources for DOHH Gene

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