Aliases for DOCK8-AS1 Gene

Subcategory (RNA class) for DOCK8-AS1 Gene

lncRNA

Number of RNA Genes sources:

0 / 14

Aliases for DOCK8-AS1 Gene

  • DOCK8 Antisense RNA 1 2 3 5
  • Chromosome 9 Open Reading Frame 66 2
  • DOCK8-AS1 2
  • C9orf66 3

External Ids for DOCK8-AS1 Gene

Previous HGNC Symbols for DOCK8-AS1 Gene

  • C9orf66

Summaries for DOCK8-AS1 Gene

GeneCards Summary for DOCK8-AS1 Gene

DOCK8-AS1 (DOCK8 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with DOCK8-AS1 include Hyper Ige Syndrome and Seckel Syndrome 1.

Additional gene information for DOCK8-AS1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DOCK8-AS1 Gene

Genomics for DOCK8-AS1 Gene

GeneHancer (GH) Regulatory Elements for DOCK8-AS1 Gene

Promoters and enhancers for DOCK8-AS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DOCK8-AS1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DOCK8-AS1

Genomic Locations for DOCK8-AS1 Gene

Genomic Locations for DOCK8-AS1 Gene
chr9:212,824-215,893
(GRCh38/hg38)
Size:
3,070 bases
Orientation:
Minus strand
chr9:213,108-215,893
(GRCh37/hg19)
Size:
2,786 bases
Orientation:
Minus strand

Genomic View for DOCK8-AS1 Gene

Genes around DOCK8-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOCK8-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOCK8-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOCK8-AS1 Gene

Proteins for DOCK8-AS1 Gene

Post-translational modifications for DOCK8-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DOCK8-AS1 Gene

Domains & Families for DOCK8-AS1 Gene

Gene Families for DOCK8-AS1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DOCK8-AS1 Gene

GenScript: Design optimal peptide antigens:
  • C9orf66 protein (Q0VG94_HUMAN)
genes like me logo Genes that share domains with DOCK8-AS1: view

No data available for Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DOCK8-AS1 Gene

Function for DOCK8-AS1 Gene

Phenotypes From GWAS Catalog for DOCK8-AS1 Gene

genes like me logo Genes that share phenotypes with DOCK8-AS1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DOCK8-AS1 Gene

Localization for DOCK8-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOCK8-AS1 gene
Compartment Confidence
nucleus 3
mitochondrion 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DOCK8-AS1 Gene

Pathways & Interactions for DOCK8-AS1 Gene

PathCards logo

SuperPathways for DOCK8-AS1 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for DOCK8-AS1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for DOCK8-AS1 Gene

Drugs & Compounds for DOCK8-AS1 Gene

No Compound Related Data Available

Transcripts for DOCK8-AS1 Gene

mRNA/cDNA for DOCK8-AS1 Gene

3 RNACentral transcripts :
2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOCK8-AS1 Gene

No ASD Table

Relevant External Links for DOCK8-AS1 Gene

GeneLoc Exon Structure for
DOCK8-AS1

Expression for DOCK8-AS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DOCK8-AS1

SOURCE GeneReport for Unigene cluster for DOCK8-AS1 Gene:

Hs.190877
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOCK8-AS1 Gene

Orthologs for DOCK8-AS1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DOCK8-AS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf66 30
  • 93.79 (n)
Species where no ortholog for DOCK8-AS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DOCK8-AS1 Gene

ENSEMBL:
Gene Tree for DOCK8-AS1 (if available)
TreeFam:
Gene Tree for DOCK8-AS1 (if available)

Paralogs for DOCK8-AS1 Gene

No data available for Paralogs for DOCK8-AS1 Gene

Variants for DOCK8-AS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DOCK8-AS1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
673270 Benign: not provided 215,057(-) T/C NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
674418 Benign: not provided 214,804(-) A/G NON_CODING_TRANSCRIPT_VARIANT,GENIC_UPSTREAM_TRANSCRIPT_VARIANT
676901 Benign: not provided 215,269(-) A/C NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
712348 Benign: not provided 214,991(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
753875 Likely Benign: not provided 215,039(-) C/T NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for DOCK8-AS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DOCK8-AS1 Gene

Variant ID Type Subtype PubMed ID
dgv12447n54 CNV gain 21841781
dgv12448n54 CNV gain 21841781
dgv12449n54 CNV gain 21841781
dgv12450n54 CNV gain 21841781
dgv253e55 CNV gain 17911159
dgv254e55 CNV gain 17911159
dgv7343n100 CNV gain 25217958
dgv7344n100 CNV gain 25217958
dgv7345n100 CNV gain 25217958
dgv7346n100 CNV gain 25217958
dgv7347n100 CNV gain 25217958
dgv7348n100 CNV gain 25217958
dgv7349n100 CNV gain 25217958
dgv7350n100 CNV gain 25217958
dgv7351n100 CNV gain 25217958
dgv7352n100 CNV gain 25217958
dgv7353n100 CNV gain 25217958
dgv7354n100 CNV gain 25217958
dgv908n27 CNV gain 19166990
dgv909n27 CNV gain 19166990
esv2759654 CNV gain+loss 17122850
esv2764172 CNV gain+loss 21179565
esv32541 CNV gain 17666407
esv3576612 CNV gain 25503493
esv3576613 CNV gain 25503493
esv3619174 CNV loss 21293372
esv3891501 CNV gain 25118596
esv3891505 CNV gain 25118596
esv3891507 CNV gain+loss 25118596
esv3891508 CNV gain 25118596
esv3891510 CNV loss 25118596
nsv1020561 CNV loss 25217958
nsv1023234 CNV loss 25217958
nsv1032134 CNV loss 25217958
nsv1119254 CNV duplication 24896259
nsv442127 CNV gain 18776908
nsv466028 CNV gain 19166990
nsv515505 CNV gain+loss 19592680
nsv612983 CNV gain 21841781
nsv612986 CNV loss 21841781
nsv612987 CNV gain 21841781
nsv818668 CNV gain 17921354
nsv8403 CNV gain+loss 18304495
nsv950829 CNV duplication 24416366

Variation tolerance for DOCK8-AS1 Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.56; 95.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DOCK8-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOCK8-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK8-AS1 Gene

Disorders for DOCK8-AS1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DOCK8-AS1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hyper ige syndrome
  • job syndrome
seckel syndrome 1
  • sckl1
sc phocomelia syndrome
  • sc pseudothalidomide syndrome
norwegian scabies
  • crusted scabies
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with DOCK8-AS1: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for DOCK8-AS1 Gene

Publications for DOCK8-AS1 Gene

  1. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 54
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 54
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

No data available for Mastermind for DOCK8-AS1 Gene

Products for DOCK8-AS1 Gene

Sources for DOCK8-AS1 Gene