This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 an... See more...

Aliases for DOCK6 Gene

Aliases for DOCK6 Gene

  • Dedicator Of Cytokinesis 6 2 3 5
  • Dedicator Of Cytokinesis Protein 6 3 4
  • KIAA1395 2 4
  • ZIR1 2 3
  • DOCK6 5
  • AOS2 3

External Ids for DOCK6 Gene

Previous GeneCards Identifiers for DOCK6 Gene

  • GC19U900290
  • GC19M011171
  • GC19M011309
  • GC19M010887

Summaries for DOCK6 Gene

Entrez Gene Summary for DOCK6 Gene

  • This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]

GeneCards Summary for DOCK6 Gene

DOCK6 (Dedicator Of Cytokinesis 6) is a Protein Coding gene. Diseases associated with DOCK6 include Adams-Oliver Syndrome 2 and Adams-Oliver Syndrome. Among its related pathways are Regulation of CDC42 activity and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK7.

UniProtKB/Swiss-Prot Summary for DOCK6 Gene

  • Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity).

Gene Wiki entry for DOCK6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DOCK6 Gene

Genomics for DOCK6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DOCK6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J011261 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.3 323 2.4 CREB1 CTCF PRDM10 ZHX2 LARP7 MTA2 ZNF143 RBFOX2 PATZ1 ZNF740 DOCK6 RF00017-2817 ENSG00000267174 ANGPTL8
GH19J011202 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.8 +58.8 58814 3.1 CTCF ZBTB33 PRDM10 ZNF692 JUND ZIC2 RXRB PATZ1 REST NR2C1 LOC105372273 ANGPTL8 DOCK6 KANK2 ENSG00000279807
GH19J011264 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 9 -2.9 -2948 2.8 HNRNPL CREB1 GATAD2A TFE3 SOX13 NFKBIZ KDM1A RCOR2 TARDBP RXRB piR-50437-335 ENSG00000267174 ILF3 TIMM29 ZNF844 ZNF433 ZNF627 KRI1 ZNF136 ZNF441
GH19J011247 Enhancer 0.8 Ensembl ENCODE dbSUPER 13.1 +14.7 14723 1.2 SP1 NR2F2 ZNF189 HNF4A ZKSCAN8 DOCK6 ENSG00000267174 lnc-KANK2-6 lnc-KANK2-7 ANGPTL8
GH19J011293 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas 5.8 -31.5 -31469 1.3 CEBPG SP1 HNRNPL CREB1 CTCF ZBTB33 PRDM10 ZNF629 IKZF1 ZNF692 ILF3 ENSG00000267174 KRI1 ZNF136 RAVER1 ZNF627 ZNF700 CDC37 ZNF844 ZNF823
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DOCK6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DOCK6

Top Transcription factor binding sites by QIAGEN in the DOCK6 gene promoter:
  • AP-4
  • Bach1
  • C/EBPalpha
  • E47
  • Max1
  • MyoD
  • NF-kappaB
  • NF-kappaB1
  • RREB-1
  • Tal-1

Genomic Locations for DOCK6 Gene

Genomic Locations for DOCK6 Gene
chr19:11,199,295-11,262,524
(GRCh38/hg38)
Size:
63,230 bases
Orientation:
Minus strand
chr19:11,309,971-11,373,157
(GRCh37/hg19)
Size:
63,187 bases
Orientation:
Minus strand

Genomic View for DOCK6 Gene

Genes around DOCK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOCK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOCK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOCK6 Gene

Proteins for DOCK6 Gene

  • Protein details for DOCK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HP0-DOCK6_HUMAN
    Recommended name:
    Dedicator of cytokinesis protein 6
    Protein Accession:
    Q96HP0
    Secondary Accessions:
    • A6H8X5
    • Q7Z7P4
    • Q9P2F2

    Protein attributes for DOCK6 Gene

    Size:
    2047 amino acids
    Molecular mass:
    229558 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08335.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA92633.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for DOCK6 Gene

Post-translational modifications for DOCK6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DOCK6 Gene

Domains & Families for DOCK6 Gene

Gene Families for DOCK6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for DOCK6 Gene

InterPro:
Blocks:
  • Dedicator of cytokinesis
ProtoNet:

Suggested Antigen Peptide Sequences for DOCK6 Gene

GenScript: Design optimal peptide antigens:
  • Dedicator of cytokinesis protein 6 (DOCK6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96HP0

UniProtKB/Swiss-Prot:

DOCK6_HUMAN :
  • The DOCKER domain may mediate some GEF activity.
  • Belongs to the DOCK family.
Domain:
  • The DOCKER domain may mediate some GEF activity.
Family:
  • Belongs to the DOCK family.
genes like me logo Genes that share domains with DOCK6: view

Function for DOCK6 Gene

Molecular function for DOCK6 Gene

UniProtKB/Swiss-Prot Function:
Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity).

Phenotypes From GWAS Catalog for DOCK6 Gene

Gene Ontology (GO) - Molecular Function for DOCK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with DOCK6: view
genes like me logo Genes that share phenotypes with DOCK6: view

Human Phenotype Ontology for DOCK6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for DOCK6 Gene

miRTarBase miRNAs that target DOCK6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DOCK6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DOCK6 Gene

Localization for DOCK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOCK6 Gene

Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly located near the cell surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOCK6 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DOCK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with DOCK6: view

Pathways & Interactions for DOCK6 Gene

genes like me logo Genes that share pathways with DOCK6: view

Pathways by source for DOCK6 Gene

1 GeneGo (Thomson Reuters) pathway for DOCK6 Gene
  • G-protein signaling_Regulation of CDC42 activity

Gene Ontology (GO) - Biological Process for DOCK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with DOCK6: view

No data available for SIGNOR curated interactions for DOCK6 Gene

Drugs & Compounds for DOCK6 Gene

(3) Drugs for DOCK6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DOCK6: view

Transcripts for DOCK6 Gene

mRNA/cDNA for DOCK6 Gene

2 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DOCK6

Alternative Splicing Database (ASD) splice patterns (SP) for DOCK6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
SP1:
SP2: - -
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30a · 30b ^ 31 ^ 32 ^ 33 ^ 34a · 34b ^ 35
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:

Relevant External Links for DOCK6 Gene

GeneLoc Exon Structure for
DOCK6

Expression for DOCK6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DOCK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DOCK6 Gene

This gene is overexpressed in Esophagus (22.4), Placenta (15.9), and Peripheral blood mononuclear cells (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DOCK6 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DOCK6

SOURCE GeneReport for Unigene cluster for DOCK6 Gene:

Hs.591002

mRNA Expression by UniProt/SwissProt for DOCK6 Gene:

Q96HP0-DOCK6_HUMAN
Tissue specificity: Widely expressed. Expressed at low level in spleen, cerebellum, hippocampus and in substantia nigra.

Evidence on tissue expression from TISSUES for DOCK6 Gene

  • Nervous system(4.5)
  • Kidney(4.4)
  • Liver(4.4)
  • Spleen(4.4)
  • Skin(2.7)
  • Intestine(2.2)
  • Heart(2.1)
  • Blood(2.1)
  • Lung(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DOCK6 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • meninges
  • mouth
  • nose
  • outer ear
  • scalp
  • skull
Thorax:
  • aorta
  • breast
  • chest wall
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • sternum
Abdomen:
  • abdominal wall
Pelvis:
  • placenta
  • uterus
Limb:
  • ankle
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • hair
  • peripheral nervous system
  • skin
genes like me logo Genes that share expression patterns with DOCK6: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for DOCK6 Gene

Orthologs for DOCK6 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOCK6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DOCK6 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia DOCK6 30 31
  • 88.98 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DOCK6 30 31
  • 88.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dock6 30
  • 85.04 (n)
Mouse
(Mus musculus)
Mammalia Dock6 30 17 31
  • 84.7 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DOCK6 31
  • 77 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DOCK6 31
  • 71 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DOCK6 31
  • 71 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dock7 30
  • 68.67 (n)
Zebrafish
(Danio rerio)
Actinopterygii DOCK6 31
  • 69 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG11376 31
  • 47 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea F46H5.4 31
  • 31 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 44 (a)
OneToMany
Species where no ortholog for DOCK6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DOCK6 Gene

ENSEMBL:
Gene Tree for DOCK6 (if available)
TreeFam:
Gene Tree for DOCK6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DOCK6: view image

Paralogs for DOCK6 Gene

Paralogs for DOCK6 Gene

(8) SIMAP similar genes for DOCK6 Gene using alignment to 7 proteins:

  • DOCK6_HUMAN
  • C9IZV6_HUMAN
  • K7EKT0_HUMAN
  • K7EP20_HUMAN
  • K7EP51_HUMAN
  • K7ERK2_HUMAN
  • K7ESB7_HUMAN
genes like me logo Genes that share paralogs with DOCK6: view

Variants for DOCK6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DOCK6 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
31128 Pathogenic: Adams-Oliver syndrome 2 11,243,569(-) C/CA NONSENSE
650992 Likely Pathogenic: not provided 11,243,884(-) T/A SPLICE_ACCEPTOR_VARIANT
708615 Likely Benign: not provided 11,215,478(-) C/T INTRON_VARIANT
708964 Likely Benign: not provided 11,252,143(-) G/A SYNONYMOUS_VARIANT
709958 Benign: not provided 11,213,188(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for DOCK6 Gene

Structural Variations from Database of Genomic Variants (DGV) for DOCK6 Gene

Variant ID Type Subtype PubMed ID
dgv3427n100 CNV gain 25217958
esv2718174 CNV deletion 23290073
esv2718175 CNV deletion 23290073
esv2718176 CNV deletion 23290073
esv2718177 CNV deletion 23290073
esv28707 CNV gain 19812545
nsv1060605 CNV gain 25217958
nsv1065030 CNV gain 25217958
nsv1072324 CNV deletion 25765185
nsv1127653 CNV deletion 24896259
nsv477048 CNV novel sequence insertion 20440878
nsv519802 CNV loss 19592680
nsv522449 CNV loss 19592680
nsv523678 CNV loss 19592680
nsv525977 CNV loss 19592680
nsv578613 CNV gain 21841781
nsv578614 CNV loss 21841781
nsv833752 CNV loss 17160897

Variation tolerance for DOCK6 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.11; 84.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DOCK6 Gene

Human Gene Mutation Database (HGMD)
DOCK6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOCK6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK6 Gene

Disorders for DOCK6 Gene

MalaCards: The human disease database

(8) MalaCards diseases for DOCK6 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
adams-oliver syndrome 2
  • aos2
adams-oliver syndrome
  • aos
oliver syndrome
  • postaxial polydactyly and mental retardation
adams-oliver syndrome 1
  • aos1
aortic valve disease 1
  • aovd1
- elite association - COSMIC cancer census association via MalaCards
Search DOCK6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DOCK6_HUMAN
  • Adams-Oliver syndrome 2 (AOS2) [MIM:614219]: A disorder characterized by the congenital absence of skin (aplasia cutis congenita) in combination with transverse limb defects. Aplasia cutis congenita can be located anywhere on the body, but in the vast majority of the cases, it is present on the posterior parietal region where it is often associated with an underlying defect of the parietal bones. Limb abnormalities are typically limb truncation defects affecting the distal phalanges or entire digits (true ectrodactyly). Only rarely, metatarsals/metacarpals or more proximal limb structures are also affected. Apart from transverse limb defects, syndactyly, most commonly of second and third toes, can also be observed. The clinical features are highly variable and can also include cardiovascular malformations, brain abnormalities and vascular defects such as cutis marmorata and dilated scalp veins. {ECO:0000269 PubMed:21820096}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for DOCK6

genes like me logo Genes that share disorders with DOCK6: view

No data available for Genatlas for DOCK6 Gene

Publications for DOCK6 Gene

  1. Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. (PMID: 12432077) Côté JF … Vuori K (Journal of cell science 2002) 2 3 4
  2. Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndrome. (PMID: 21820096) Shaheen R … Alkuraya FS (American journal of human genetics 2011) 3 4
  3. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PMID: 21347282) Lettre G … Boerwinkle E (PLoS genetics 2011) 3 41
  4. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 41
  5. Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth. (PMID: 17196961) Miyamoto Y … Tanoue A (Experimental cell research 2007) 3 4

Products for DOCK6 Gene

Sources for DOCK6 Gene