Aliases for DOCK5 Gene
External Ids for DOCK5 Gene
Previous GeneCards Identifiers for DOCK5 Gene
This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]
GeneCards Summary for DOCK5 Gene
DOCK5 (Dedicator Of Cytokinesis 5) is a Protein Coding gene. Diseases associated with DOCK5 include Li-Fraumeni Syndrome 1 and Li-Fraumeni Syndrome 2. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Factors involved in megakaryocyte development and platelet production. Gene Ontology (GO) annotations related to this gene include binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK1.
UniProtKB/Swiss-Prot Summary for DOCK5 Gene
Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).