Aliases for DOCK11 Gene
External Ids for DOCK11 Gene
Previous GeneCards Identifiers for DOCK11 Gene
GeneCards Summary for DOCK11 Gene
DOCK11 (Dedicator Of Cytokinesis 11) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Regulation of CDC42 activity. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Rho GTPase binding. An important paralog of this gene is DOCK9.
UniProtKB/Swiss-Prot for DOCK11 Gene
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42.