Aliases for DOCK11 Gene

Aliases for DOCK11 Gene

  • Dedicator Of Cytokinesis 11 2 3 5
  • Dedicator Of Cytokinesis Protein 11 3 4
  • Zizimin-2 3 4
  • Zizimin2 2 3
  • ZIZ2 3 4
  • ACG 3 4
  • Activated Cdc42-Associated Guanine Nucleotide Exchange Factor, ACG 3
  • Activated Cdc42-Associated Guanine Nucleotide Exchange Factor 4
  • BB128O4.1.1 (Novel Protein) 3
  • BB128O4.1 3

External Ids for DOCK11 Gene

Previous GeneCards Identifiers for DOCK11 Gene

  • GC0XP116476
  • GC0XP116383
  • GC0XP117411
  • GC0XP117513
  • GC0XP117629
  • GC0XP107125

Summaries for DOCK11 Gene

GeneCards Summary for DOCK11 Gene

DOCK11 (Dedicator Of Cytokinesis 11) is a Protein Coding gene. Diseases associated with DOCK11 include Viral Laryngitis and Shoulder Impingement Syndrome. Among its related pathways are Regulation of CDC42 activity and Factors involved in megakaryocyte development and platelet production. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Rho GTPase binding. An important paralog of this gene is DOCK9.

UniProtKB/Swiss-Prot Summary for DOCK11 Gene

  • Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42.

Gene Wiki entry for DOCK11 Gene

Additional gene information for DOCK11 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DOCK11 Gene

Genomics for DOCK11 Gene

GeneHancer (GH) Regulatory Elements for DOCK11 Gene

Promoters and enhancers for DOCK11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ118494 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 506.7 +1.2 1177 5.7 NRF1 USF1 ZIC2 ZBTB10 TCF7 ZNF423 AFF1 ZBTB26 KLF7 TOE1 DOCK11 ENSG00000206862
GH0XJ118519 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 22.2 +26.6 26560 6 JUND FOS ZNF10 MYC CTBP1 NCOR1 MBD2 TCF12 NFIC TRIM24 DOCK11 LONRF3 WDR44 ENSG00000206862
GH0XJ118557 Enhancer 0.9 Ensembl 21.5 +61.6 61567 0.7 PHB2 AFF1 TOE1 MYC HDAC3 NCOR1 NFRKB RELA NFIC ARNT DOCK11 ENSG00000206862
GH0XJ118527 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 15.9 +33.4 33448 4.4 ZBTB40 ZSCAN5C POLR2A WT1 CBFB ZNF384 CEBPG IRF1 ELF1 ZBTB48 LONRF3 DOCK11 IL13RA1 ENSG00000206862
GH0XJ118723 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 7.3 +231.6 231576 7.9 EP300 ZNF217 NRF1 TCF12 POLR2G NCOR1 PHF8 FOS ZFX ZIC2 IL13RA1 lnc-KIAA1210-7 LONRF3 DOCK11 ZCCHC12 lnc-DOCK11-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DOCK11 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DOCK11

Top Transcription factor binding sites by QIAGEN in the DOCK11 gene promoter:
  • GATA-3
  • Nkx2-5
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • POU2F1
  • POU2F1a
  • STAT5A

Genomic Locations for DOCK11 Gene

Genomic Locations for DOCK11 Gene
chrX:118,495,898-118,686,163
(GRCh38/hg38)
Size:
190,266 bases
Orientation:
Plus strand
chrX:117,629,861-117,820,126
(GRCh37/hg19)
Size:
190,266 bases
Orientation:
Plus strand

Genomic View for DOCK11 Gene

Genes around DOCK11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOCK11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOCK11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOCK11 Gene

Proteins for DOCK11 Gene

  • Protein details for DOCK11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JSL3-DOC11_HUMAN
    Recommended name:
    Dedicator of cytokinesis protein 11
    Protein Accession:
    Q5JSL3
    Secondary Accessions:
    • A6NMF0
    • Q66M66
    • Q6ZUJ5
    • Q86VU8
    • Q96MN3

    Protein attributes for DOCK11 Gene

    Size:
    2073 amino acids
    Molecular mass:
    237671 Da
    Quaternary structure:
    • Interacts with CDC42.
    Miscellaneous:
    • 'Zizim' means 'spike' in Hebrew.
    SequenceCaution:
    • Sequence=BAB71253.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC86230.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for DOCK11 Gene

Post-translational modifications for DOCK11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOCK11 Gene

No data available for DME Specific Peptides for DOCK11 Gene

Domains & Families for DOCK11 Gene

Protein Domains for DOCK11 Gene

Suggested Antigen Peptide Sequences for DOCK11 Gene

GenScript: Design optimal peptide antigens:
  • Zizimin-2 (DOC11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5JSL3

UniProtKB/Swiss-Prot:

DOC11_HUMAN :
  • The DHR-2 domain is necessary for the GEF activity. The DHR-2 domain mediates interaction with activated CDC42 in conjunction with residues 66-126.
  • Belongs to the DOCK family.
Domain:
  • The DHR-2 domain is necessary for the GEF activity. The DHR-2 domain mediates interaction with activated CDC42 in conjunction with residues 66-126.
Family:
  • Belongs to the DOCK family.
genes like me logo Genes that share domains with DOCK11: view

Function for DOCK11 Gene

Molecular function for DOCK11 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42.

Gene Ontology (GO) - Molecular Function for DOCK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity ISS,IEA --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 25074804
GO:0017048 Rho GTPase binding IEA --
genes like me logo Genes that share ontologies with DOCK11: view
genes like me logo Genes that share phenotypes with DOCK11: view

Animal Models for DOCK11 Gene

MGI Knock Outs for DOCK11:
  • Dock11 Dock11<tm2b(KOMP)Wtsi>

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOCK11 Gene

Localization for DOCK11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOCK11 gene
Compartment Confidence
cytosol 5
plasma membrane 4
cytoskeleton 2
nucleus 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DOCK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DOCK11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOCK11 Gene

Pathways & Interactions for DOCK11 Gene

genes like me logo Genes that share pathways with DOCK11: view

Pathways by source for DOCK11 Gene

1 BioSystems pathway for DOCK11 Gene
1 GeneGo (Thomson Reuters) pathway for DOCK11 Gene
  • G-protein signaling_Regulation of CDC42 activity

Gene Ontology (GO) - Biological Process for DOCK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001782 B cell homeostasis ISS --
GO:0002315 marginal zone B cell differentiation ISS,IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007596 blood coagulation TAS --
GO:0043547 positive regulation of GTPase activity ISS,IEA --
genes like me logo Genes that share ontologies with DOCK11: view

No data available for SIGNOR curated interactions for DOCK11 Gene

Drugs & Compounds for DOCK11 Gene

(1) Drugs for DOCK11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DOCK11: view

Transcripts for DOCK11 Gene

mRNA/cDNA for DOCK11 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOCK11 Gene

No ASD Table

Relevant External Links for DOCK11 Gene

GeneLoc Exon Structure for
DOCK11

Expression for DOCK11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DOCK11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOCK11 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for DOCK11 Gene

This gene is overexpressed in Nasal epithelium (21.5), Lavage (20.1), Peripheral blood mononuclear cells (8.3), and Lymph node (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DOCK11 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DOCK11

SOURCE GeneReport for Unigene cluster for DOCK11 Gene:

Hs.368203

Evidence on tissue expression from TISSUES for DOCK11 Gene

  • Nervous system(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with DOCK11: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOCK11 Gene

Orthologs for DOCK11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DOCK11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOCK11 31 30
  • 99.54 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DOCK11 31 30
  • 93.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DOCK11 31 30
  • 92.84 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dock11 17 31 30
  • 91.01 (n)
rat
(Rattus norvegicus)
Mammalia Dock11 30
  • 90.82 (n)
oppossum
(Monodelphis domestica)
Mammalia DOCK11 31
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOCK11 31
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves DOCK11 31 30
  • 76.17 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOCK11 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dock11 30
  • 73.08 (n)
zebrafish
(Danio rerio)
Actinopterygii dock11 31
  • 65 (a)
OneToOne
LOC799686 30
  • 64.26 (n)
Species where no ortholog for DOCK11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOCK11 Gene

ENSEMBL:
Gene Tree for DOCK11 (if available)
TreeFam:
Gene Tree for DOCK11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DOCK11: view image

Paralogs for DOCK11 Gene

Paralogs for DOCK11 Gene

(6) SIMAP similar genes for DOCK11 Gene using alignment to 3 proteins:

  • DOC11_HUMAN
  • A6NIW2_HUMAN
  • L8E958_HUMAN

Pseudogenes.org Pseudogenes for DOCK11 Gene

genes like me logo Genes that share paralogs with DOCK11: view

Variants for DOCK11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DOCK11 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
721200 Likely Benign: not provided 118,599,191(+) C/T MISSENSE_VARIANT
728497 Benign: not provided 118,676,003(+) A/G MISSENSE_VARIANT
734250 Likely Benign: not provided 118,624,563(+) T/C SYNONYMOUS_VARIANT
774975 Benign: not provided 118,605,272(+) A/G MISSENSE_VARIANT
780718 Benign: not provided 118,628,156(+) T/C INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for DOCK11 Gene

Structural Variations from Database of Genomic Variants (DGV) for DOCK11 Gene

Variant ID Type Subtype PubMed ID
dgv527n21 CNV gain 19592680
esv1557323 CNV insertion 17803354
nsv510553 OTHER sequence alteration 20534489
nsv522227 CNV gain 19592680

Variation tolerance for DOCK11 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DOCK11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOCK11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK11 Gene

Disorders for DOCK11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DOCK11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
viral laryngitis
shoulder impingement syndrome
  • impingement syndrome of shoulder region
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DOCK11

genes like me logo Genes that share disorders with DOCK11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DOCK11 Gene

Publications for DOCK11 Gene

  1. Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42. (PMID: 16968698) Lin Q … Cerione RA (The Journal of biological chemistry 2006) 2 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. (PMID: 12432077) Côté JF … Vuori K (Journal of cell science 2002) 2 3 54
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 54

Products for DOCK11 Gene

Sources for DOCK11 Gene