Aliases for DOCK11 Gene
External Ids for DOCK11 Gene
Previous GeneCards Identifiers for DOCK11 Gene
GeneCards Summary for DOCK11 Gene
DOCK11 (Dedicator Of Cytokinesis 11) is a Protein Coding gene. Diseases associated with DOCK11 include Viral Laryngitis and Shoulder Impingement Syndrome. Among its related pathways are Regulation of CDC42 activity and Factors involved in megakaryocyte development and platelet production. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Rho GTPase binding. An important paralog of this gene is DOCK9.
UniProtKB/Swiss-Prot Summary for DOCK11 Gene
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42.