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This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
DOCK10 (Dedicator Of Cytokinesis 10) is a Protein Coding gene. Diseases associated with DOCK10 include Immunodeficiency 40. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Regulation of CDC42 activity. Gene Ontology (GO) annotations related to this gene include binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK9.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0005085 | guanyl-nucleotide exchange factor activity | IEA,ISS | -- |
GO:0005515 | protein binding | IPI | 32296183 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 18499258 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 18499258 |
GO:0005829 | cytosol | IDA | -- |
GO:0016020 | membrane | HDA | 19946888 |
Symbol | External ID(s) | Details |
---|---|---|
MAGEA11 | ||
CDC42 | ||
DOCK9 | ||
ENSG00000272822 | ||
HAL |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001782 | B cell homeostasis | ISS | -- |
GO:0002315 | marginal zone B cell differentiation | ISS | -- |
GO:0007264 | small GTPase mediated signal transduction | IEA | -- |
GO:0030334 | regulation of cell migration | IDA | 18835169 |
GO:0043547 | positive regulation of GTPase activity | ISS | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DOCK10 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DOCK10 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DOCK10 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dock10 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dock10 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | DOCK10 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | DOCK10 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DOCK10 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dock10 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dock10 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs114242232 | Benign: not provided | 224,874,723(-) |
T/G NM_014689.3(DOCK10):c.960A>C (p.Glu320Asp) |
MISSENSE | |
rs116790520 | Benign: not provided | 224,805,210(-) |
C/T NM_014689.3(DOCK10):c.4047G>A (p.Ser1349=) |
SYNONYMOUS | |
rs16866166 | Benign: not provided | 224,773,259(-) |
G/A NM_014689.3(DOCK10):c.6102C>T (p.Asp2034=) |
SYNONYMOUS | |
rs16866167 | Benign: not provided | 224,775,068(-) |
G/A NM_014689.3(DOCK10):c.5850C>T (p.Thr1950=) |
SYNONYMOUS | |
rs57422537 | Benign: not provided | 224,800,267(-) |
T/C NM_014689.3(DOCK10):c.4394-4A>G |
INTRON |
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency 40 |
|
|