DOCK10 Gene (Protein Coding)

Dedicator Of Cytokinesis 10

GC02M224765
GIFtS:
39
This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced... See more...

Aliases for DOCK10 Gene

Aliases for DOCK10 Gene

  • Dedicator Of Cytokinesis 10 2 3 5
  • ZIZ3 2 3 4
  • Dedicator Of Cytokinesis Protein 10 3 4
  • Zizimin3 2 3
  • KIAA0694 2 4
  • Dopamine Receptor Interacting Protein 2 3
  • Nbla10300 3
  • Zizimin-3 4
  • DOCK10 5
  • DRIP2 3

External Ids for DOCK10 Gene

Previous GeneCards Identifiers for DOCK10 Gene

  • GC02M225593
  • GC02M225832
  • GC02M225455
  • GC02M225338
  • GC02M217481

Summaries for DOCK10 Gene

Entrez Gene Summary for DOCK10 Gene

  • This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]

GeneCards Summary for DOCK10 Gene

DOCK10 (Dedicator Of Cytokinesis 10) is a Protein Coding gene. Diseases associated with DOCK10 include Immunodeficiency 40. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Regulation of CDC42 activity. Gene Ontology (GO) annotations related to this gene include binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK9.

UniProtKB/Swiss-Prot Summary for DOCK10 Gene

  • Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.

Gene Wiki entry for DOCK10 Gene

Additional gene information for DOCK10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DOCK10 Gene

Genomics for DOCK10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for DOCK10 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J225037 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 261 +2.1 2110 6 ZBTB10 BCL11A POLR2A SIN3A REST EBF1 SMARCA5 MAX CBFB TAF1 DOCK10 NYAP2 CUL3 MIR4439 lnc-NYAP2-10 CCDC195
GH02J224943 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 272.1 +96.2 96199 7 NR2C1 POLR2A SIN3A GABPA IRF4 TRIM22 CBFB SPI1 BHLHE40 JUND DOCK10 NYAP2 CUL3 HSALNG0022654 lnc-NYAP2-10 CCDC195
GH02J224881 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 29.7 +158.2 158224 6 BCL11A CTCF CEBPB ZNF623 IRF4 EP300 RXRA SMC3 ZBTB33 JUND DOCK10 HSALNG0022653 lnc-CCDC195-2 CCDC195
GH02J225009 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 17 +31.7 31747 2.8 YY1 FOSL1 JUND MAFK GLIS1 POLR2A CTCF NFE2L2 FOS EP300 MIR4439 DOCK10 NYAP2 lnc-NYAP2-10 CCDC195
GH02J224893 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +147.9 147873 2 SMARCA5 SPI1 ZNF24 ELF1 NFATC1 IKZF1 MTA3 ATF2 JUNB NKRF DOCK10 CUL3 HSALNG0022653 lnc-CCDC195-2 CCDC195
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DOCK10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DOCK10

Top Transcription factor binding sites by QIAGEN in the DOCK10 gene promoter:
  • CREB
  • CUTL1
  • deltaCREB
  • Elk-1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT6

Genomic Locations for DOCK10 Gene

Latest Assembly
chr2:224,765,090-225,042,689
(GRCh38/hg38)
Size:
277,600 bases
Orientation:
Minus strand

Previous Assembly
chr2:225,629,807-225,907,185
(GRCh37/hg19 by Entrez Gene)
Size:
277,379 bases
Orientation:
Minus strand

chr2:225,629,807-225,907,162
(GRCh37/hg19 by Ensembl)
Size:
277,356 bases
Orientation:
Minus strand

Genomic View for DOCK10 Gene

Genes around DOCK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOCK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOCK10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DOCK10 Gene

Proteins for DOCK10 Gene

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  • Protein details for DOCK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BY6-DOC10_HUMAN
    Recommended name:
    Dedicator of cytokinesis protein 10
    Protein Accession:
    Q96BY6
    Secondary Accessions:
    • B3FL70
    • O75178
    • Q68DA4
    • Q9NW06
    • Q9NXI8

    Protein attributes for DOCK10 Gene

    Size:
    2186 amino acids
    Molecular mass:
    249531 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15018.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA31669.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA91022.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA91583.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAH18316.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • 'Zizim' means 'spike' in Hebrew.

    Three dimensional structures from OCA and Proteopedia for DOCK10 Gene

    Alternative splice isoforms for DOCK10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOCK10 Gene

Protein Expression for DOCK10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DOCK10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOCK10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DOCK10 Gene

Domains & Families for DOCK10 Gene

Gene Families for DOCK10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DOCK10 Gene

InterPro:
Blocks:
  • Pleckstrin-like
  • Dedicator of cytokinesis
ProtoNet:

Suggested Antigen Peptide Sequences for DOCK10 Gene

GenScript: Design optimal peptide antigens:
  • Zizimin-3 (DOC10_HUMAN)
  • Dopamine receptor interacting protein 2 (Q4W4X9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96BY6

UniProtKB/Swiss-Prot:

DOC10_HUMAN :
  • The DOCKER domain may mediate some GEF activity.
  • Belongs to the DOCK family.
Domain:
  • The DOCKER domain may mediate some GEF activity.
Family:
  • Belongs to the DOCK family.
genes like me logo Genes that share domains with DOCK10: view

Function for DOCK10 Gene

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  6. Cell Lines for research

Molecular function for DOCK10 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
UniProtKB/Swiss-Prot Induction:
Isoforms 1 and 2 are up-regulated in response to IL4 in B-cells but not T-cells.

Phenotypes From GWAS Catalog for DOCK10 Gene

Gene Ontology (GO) - Molecular Function for DOCK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005085 guanyl-nucleotide exchange factor activity IEA,ISS --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with DOCK10: view
genes like me logo Genes that share phenotypes with DOCK10: view

Animal Models for DOCK10 Gene

MGI Knock Outs for DOCK10:
  • Dock10 Dock10<tm1a(EUCOMM)Hmgu>

Animal Models for research

miRNA for DOCK10 Gene

miRTarBase miRNAs that target DOCK10

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DOCK10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOCK10 Gene

Localization for DOCK10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOCK10 Gene

Nucleus. Cytoplasm. Cell projection, dendritic spine.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOCK10 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 4
plasma membrane 2
mitochondrion 2
cytoskeleton 1
peroxisome 1
lysosome 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DOCK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18499258
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 18499258
GO:0005829 cytosol IDA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DOCK10: view

Pathways & Interactions for DOCK10 Gene

genes like me logo Genes that share pathways with DOCK10: view

Pathways by source for DOCK10 Gene

1 BioSystems pathway for DOCK10 Gene

SIGNOR curated interactions for DOCK10 Gene

Activates:

Gene Ontology (GO) - Biological Process for DOCK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001782 B cell homeostasis ISS --
GO:0002315 marginal zone B cell differentiation ISS --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0030334 regulation of cell migration IDA 18835169
GO:0043547 positive regulation of GTPase activity ISS --
genes like me logo Genes that share ontologies with DOCK10: view

Drugs & Compounds for DOCK10 Gene

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(3) Drugs for DOCK10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DOCK10: view

Transcripts for DOCK10 Gene

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mRNA/cDNA for DOCK10 Gene

4 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DOCK10

Alternative Splicing Database (ASD) splice patterns (SP) for DOCK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: -
SP3:

Relevant External Links for DOCK10 Gene

GeneLoc Exon Structure for
DOCK10

Expression for DOCK10 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DOCK10 Gene

mRNA expression in normal human tissues for DOCK10 Gene
mRNA expression by GTEx for DOCK10 GenemRNA expression by BioGPS for DOCK10 Gene

mRNA differential expression in normal tissues according to GTEx for DOCK10 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.6).

Protein differential expression in normal tissues from HIPED for DOCK10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.2), Lymph node (15.8), CD8 Tcells (6.9), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DOCK10 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DOCK10

SOURCE GeneReport for Unigene cluster for DOCK10 Gene:

Hs.46578

mRNA Expression by UniProt/SwissProt for DOCK10 Gene:

Q96BY6-DOC10_HUMAN
Tissue specificity: Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.

Evidence on tissue expression from TISSUES for DOCK10 Gene

  • Nervous system(4.6)
  • Blood(4.4)
  • Intestine(4.3)
  • Bone marrow(4.3)
  • Skin(4.3)
  • Spleen(2.3)
genes like me logo Genes that share expression patterns with DOCK10: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOCK10 Gene

Orthologs for DOCK10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DOCK10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia DOCK10 30 31
  • 99.53 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia DOCK10 30 31
  • 91.73 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia DOCK10 30 31
  • 90.88 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Dock10 30 17 31
  • 87.44 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Dock10 30
  • 87.41 (n)
Oppossum
(Monodelphis domestica)
 Mammalia DOCK10 31
  • 86 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 84 (a)
 OneToMany
-- 31
  • 78 (a)
 OneToMany
-- 31
  • 73 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves DOCK10 30 31
  • 78.37 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia DOCK10 31
  • 81 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia dock10 30
  • 71.93 (n)
Zebrafish
(Danio rerio)
 Actinopterygii dock10 30 31
  • 67.16 (n)
 OneToOne
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 59 (a)
 OneToOne
Species where no ortholog for DOCK10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DOCK10 Gene

ENSEMBL:
Gene Tree for DOCK10 (if available)
TreeFam:
Gene Tree for DOCK10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DOCK10: view image

Paralogs for DOCK10 Gene

Paralogs for DOCK10 Gene

(9) SIMAP similar genes for DOCK10 Gene using alignment to 6 proteins:

  • DOC10_HUMAN
  • F8WB48_HUMAN
  • F8WE73_HUMAN
  • H0YFC5_HUMAN
  • H7C0I3_HUMAN
  • Q4ZG60_HUMAN
genes like me logo Genes that share paralogs with DOCK10: view

Variants for DOCK10 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DOCK10 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs114242232 Benign: not provided 224,874,723(-) T/G
NM_014689.3(DOCK10):c.960A>C (p.Glu320Asp) 		MISSENSE
rs116790520 Benign: not provided 224,805,210(-) C/T
NM_014689.3(DOCK10):c.4047G>A (p.Ser1349=) 		SYNONYMOUS
rs16866166 Benign: not provided 224,773,259(-) G/A
NM_014689.3(DOCK10):c.6102C>T (p.Asp2034=) 		SYNONYMOUS
rs16866167 Benign: not provided 224,775,068(-) G/A
NM_014689.3(DOCK10):c.5850C>T (p.Thr1950=) 		SYNONYMOUS
rs57422537 Benign: not provided 224,800,267(-) T/C
NM_014689.3(DOCK10):c.4394-4A>G 		INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DOCK10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DOCK10 Gene

Variant ID Type Subtype PubMed ID
dgv2351e59 CNV duplication 20981092
dgv631e201 CNV deletion 23290073
esv1010048 CNV insertion 20482838
esv1011163 CNV insertion 20482838
esv1631002 CNV deletion 17803354
esv2663234 CNV deletion 23128226
esv2668530 CNV deletion 23128226
esv2721534 CNV deletion 23290073
esv2721535 CNV deletion 23290073
esv3303983 CNV mobile element insertion 20981092
esv3309958 CNV mobile element insertion 20981092
esv3326171 CNV insertion 20981092
esv3392806 CNV insertion 20981092
esv3405152 CNV insertion 20981092
esv3561074 CNV deletion 23714750
esv3594478 CNV gain 21293372
esv3594480 CNV loss 21293372
esv3594481 CNV loss 21293372
esv3594482 CNV loss 21293372
esv4249 CNV loss 18987735
esv8487 CNV gain 19470904
nsv1073014 CNV deletion 25765185
nsv1076504 CNV duplication 25765185
nsv1116001 CNV insertion 24896259
nsv1116831 CNV deletion 24896259
nsv1125776 CNV deletion 24896259
nsv1129212 CNV insertion 24896259
nsv1138892 CNV deletion 24896259
nsv1138893 CNV deletion 24896259
nsv3185 CNV deletion 18451855
nsv470519 CNV gain 18288195
nsv473288 CNV novel sequence insertion 20440878
nsv508131 OTHER sequence alteration 20534489
nsv517969 CNV loss 19592680
nsv954202 CNV deletion 24416366

Variation tolerance for DOCK10 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.65; 91.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DOCK10 Gene

Human Gene Mutation Database (HGMD)
DOCK10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOCK10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK10 Gene

Disorders for DOCK10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DOCK10 Gene - From: COP

Disorder Aliases PubMed IDs
immunodeficiency 40
  • imd40
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DOCK10

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DOCK10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DOCK10 Gene

Publications for DOCK10 Gene

  1. Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. (PMID: 18499258) Yelo E … Parrado A (Molecular immunology 2008) 3 4 23
  2. Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. (PMID: 12432077) Côté JF … Vuori K (Journal of cell science 2002) 2 3 4
  3. Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes. (PMID: 21514340) Alcaraz-García MJ … Parrado A (Human immunology 2011) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4

ExternalLinks

View latest publications for DOCK10 gene in Mastermind

Products for DOCK10 Gene

Sources for DOCK10 Gene