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This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
DOCK10 (Dedicator Of Cytokinesis 10) is a Protein Coding gene. Among its related pathways are Regulation of CDC42 activity and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK9.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0005085 | guanyl-nucleotide exchange factor activity | IEA,ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 18499258 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 18499258 |
GO:0005829 | cytosol | IDA | -- |
GO:0016020 | membrane | HDA | 19946888 |
Symbol | External ID(s) | Details |
---|---|---|
MAGEA11 | ||
CDC42 | ||
DOCK9 | ||
ENSG00000272822 | ||
HAL |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001782 | B cell homeostasis | ISS | -- |
GO:0002315 | marginal zone B cell differentiation | ISS | -- |
GO:0007264 | small GTPase mediated signal transduction | IEA | -- |
GO:0030334 | regulation of cell migration | IDA | 18835169 |
GO:0043547 | positive regulation of GTPase activity | ISS | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DOCK10 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DOCK10 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DOCK10 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dock10 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dock10 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | DOCK10 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | DOCK10 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DOCK10 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dock10 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dock10 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
715908 | Benign: not provided | 224,805,210(-) | C/T | SYNONYMOUS_VARIANT | |
732361 | Benign: not provided | 224,874,723(-) | T/G | MISSENSE_VARIANT | |
783211 | Benign: not provided | 224,775,068(-) | G/A | SYNONYMOUS_VARIANT | |
785994 | Benign: not provided | 224,800,267(-) | T/C | INTRON_VARIANT | |
791895 | Benign: not provided | 224,773,259(-) | G/A | SYNONYMOUS_VARIANT |
No disorders were found for DOCK10 Gene.