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This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced... See more...
Aliases for DOCK10 Gene
Aliases for DOCK10 Gene
External Ids for DOCK10 Gene
- HGNC: 23479
- Entrez Gene: 55619
- Ensembl: ENSG00000135905
- OMIM: 611518
- UniProtKB: Q96BY6
Previous GeneCards Identifiers for DOCK10 Gene
- GC02M225593
- GC02M225832
- GC02M225455
- GC02M225338
- GC02M217481
Summaries for DOCK10 Gene
-
This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
GeneCards Summary for DOCK10 Gene
DOCK10 (Dedicator Of Cytokinesis 10) is a Protein Coding gene. Among its related pathways are Regulation of CDC42 activity and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK9.
UniProtKB/Swiss-Prot Summary for DOCK10 Gene
-
Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
Additional gene information for DOCK10 Gene
- HGNC(23479)
- Entrez Gene(55619)
- Ensembl(ENSG00000135905)
- OMIM(611518)
- UniProtKB(Q96BY6)
- Open Targets Platform(ENSG00000135905)
- Search for DOCK10 at DataMed
- Search for DOCK10 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DOCK10 Gene
Genomics for DOCK10 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DOCK10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DOCK10 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DOCK10
- Top Transcription factor binding sites by QIAGEN in the DOCK10 gene promoter:
-
- CREB
- CUTL1
- deltaCREB
- Elk-1
- STAT1
- STAT1alpha
- STAT1beta
- STAT2
- STAT3
- STAT6
Genomic Locations for DOCK10 Gene
Genomic Locations for DOCK10 Gene
- chr2:224,765,090-225,042,689
- (GRCh38/hg38)
- Size:
- 277,600 bases
- Orientation:
- Minus strand
- chr2:225,629,807-225,907,330
- (GRCh37/hg19)
- Size:
- 277,524 bases
- Orientation:
- Minus strand
Genomic View for DOCK10 Gene
Genes around DOCK10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q36.2 by HGNC
- 2q36.2 by Entrez Gene
- 2q36.2 by Ensembl
DOCK10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DOCK10 Gene
Proteins for DOCK10 Gene
-
Protein details for DOCK10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96BY6-DOC10_HUMAN
- Recommended name:
- Dedicator of cytokinesis protein 10
- Protein Accession:
- Q96BY6
- B3FL70
- O75178
- Q68DA4
- Q9NW06
- Q9NXI8
Protein attributes for DOCK10 Gene
- Size:
- 2186 amino acids
- Molecular mass:
- 249531 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH15018.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA31669.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA91022.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA91583.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAH18316.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- 'Zizim' means 'spike' in Hebrew.
Protein Expression for DOCK10 Gene
Post-translational modifications for DOCK10 Gene
Other Protein References for DOCK10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for DOCK10
-
Abcam antibodies for DOCK10
- Invitrogen Antibodies for DOCK10 (AFLGC-DOCK10)
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DOCK10
- Origene Custom Protein Services for DOCK10
- Novus Biologicals proteins for DOCK10
No data available for DME Specific Peptides for DOCK10 Gene
Domains & Families for DOCK10 Gene
Gene Families for DOCK10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for DOCK10 Gene
- InterPro:
- Blocks:
-
- Pleckstrin-like
- Dedicator of cytokinesis
- ProtoNet:
Suggested Antigen Peptide Sequences for DOCK10 Gene
- GenScript: Design optimal peptide antigens:
-
- Zizimin-3 (DOC10_HUMAN)
- Dopamine receptor interacting protein 2 (Q4W4X9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96BY6UniProtKB/Swiss-Prot:
DOC10_HUMAN :- The DOCKER domain may mediate some GEF activity.
- Belongs to the DOCK family.
- Domain:
-
- The DOCKER domain may mediate some GEF activity.
- Family:
-
- Belongs to the DOCK family.
Function for DOCK10 Gene
Molecular function for DOCK10 Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
- UniProtKB/Swiss-Prot Induction:
- Isoforms 1 and 2 are up-regulated in response to IL4 in B-cells but not T-cells.
Phenotypes From GWAS Catalog for DOCK10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA,ISS | -- |
Phenotypes for DOCK10 Gene
- MGI mutant phenotypes for DOCK10:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DOCK10:
Animal Models for DOCK10 Gene
- MGI Knock Outs for DOCK10:
-
- Dock10 Dock10<tm1a(EUCOMM)Hmgu>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DOCK10 - Select products 50% OFF >
- * DOCK10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DOCK10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DOCK10
-
Santa Cruz Biotechnology (SCBT) CRISPR for DOCK10
miRNA for DOCK10 Gene
- miRTarBase miRNAs that target DOCK10
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DOCK10
- Browse OriGene Inhibitory RNA Products For DOCK10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DOCK10
Clone Products
- Applied Biological Materials (abm): Clones for DOCK10 - Select products 50% OFF >
- * DOCK10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DOCK10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DOCK10
Cell Line Products
-
Horizon Cell Lines for DOCK10
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOCK10 Gene
Localization for DOCK10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DOCK10 Gene
- Nucleus. Cytoplasm. Cell projection, dendritic spine.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| cytosol | 4 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| lysosome | 1 |
| endoplasmic reticulum | 0 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 18499258 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 18499258 |
| GO:0005829 | cytosol | IDA | -- |
| GO:0016020 | membrane | HDA | 19946888 |
Pathways & Interactions for DOCK10 Gene
Pathways by source for DOCK10 Gene
1 BioSystems pathway for DOCK10 Gene
2 Reactome pathways for DOCK10 Gene
Interacting Proteins for DOCK10 Gene
Selected Interacting proteins:
Q96BY6-DOC10_HUMAN
ENSP00000258390
for DOCK10 Gene via
UniProtKB
STRING
IID
| Symbol | External ID(s) | Details |
|---|---|---|
| MAGEA11 | ||
| CDC42 | ||
| DOCK9 | ||
| ENSG00000272822 | ||
| HAL |
GPS-Prot Interaction Network for DOCK10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001782 | B cell homeostasis | ISS | -- |
| GO:0002315 | marginal zone B cell differentiation | ISS | -- |
| GO:0007264 | small GTPase mediated signal transduction | IEA | -- |
| GO:0030334 | regulation of cell migration | IDA | 18835169 |
| GO:0043547 | positive regulation of GTPase activity | ISS | -- |
Transcripts for DOCK10 Gene
mRNA/cDNA for DOCK10 Gene
- 4 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000409592 7288 nts (view in UCSC)
- ENST00000258390 7260 nts (view in UCSC)
- ENST00000644695 7320 nts (view in UCSC)
- ENST00000645028 7276 nts (view in UCSC)
- ENST00000535663 568 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DOCK10 - Select products 50% OFF >
- * DOCK10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DOCK10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DOCK10
-
Santa Cruz Biotechnology (SCBT) CRISPR for DOCK10
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DOCK10
- Browse OriGene Inhibitory RNA Products For DOCK10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DOCK10
Clone Products
- Applied Biological Materials (abm): Clones for DOCK10 - Select products 50% OFF >
- * DOCK10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DOCK10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DOCK10
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: |
Relevant External Links for DOCK10 Gene
- GeneLoc Exon Structure for
- DOCK10
Expression for DOCK10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Spinal Cord (Nervous System)
-
Thymus (Hematopoietic System)
- T-Cytotoxic Cells Thymus
-
Blood (Cardiovascular System)
- T-Cytotoxic Cells Thymus
- Endothelium (Cardiovascular System)
- Oligodendrocytes (Nervous System)
- Glial Cells (Uncategorized)
-
Dermis (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for DOCK10 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.6).
This gene is overexpressed in Peripheral blood mononuclear cells (21.2), Lymph node (15.8), CD8 Tcells (6.9), and Pancreas (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DOCK10 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DOCK10
SOURCE GeneReport for Unigene cluster for DOCK10 Gene:
Hs.46578mRNA Expression by UniProt/SwissProt for DOCK10 Gene:
Q96BY6-DOC10_HUMAN
Tissue specificity:
Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.
Evidence on tissue expression from TISSUES for DOCK10 Gene
- Nervous system(4.7)
- Blood(4.4)
- Intestine(4.3)
- Skin(4.3)
- Bone marrow(4.3)
- Spleen(2.3)
- Lymph node(2.1)
Primer Products
-
OriGene qPCR primer pairs for DOCK10
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOCK10 Gene
Orthologs for DOCK10 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DOCK10 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DOCK10 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DOCK10 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Dock10 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dock10 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | DOCK10 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | DOCK10 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | DOCK10 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dock10 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | dock10 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for DOCK10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for DOCK10 Gene
- ENSEMBL:
- Gene Tree for DOCK10 (if available)
- TreeFam:
- Gene Tree for DOCK10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DOCK10: view image
Paralogs for DOCK10 Gene
Paralogs for DOCK10 Gene
(9) SIMAP similar genes for DOCK10 Gene using alignment to 6 proteins:
- DOC10_HUMAN
- F8WB48_HUMAN
- F8WE73_HUMAN
- H0YFC5_HUMAN
- H7C0I3_HUMAN
- Q4ZG60_HUMAN
Variants for DOCK10 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DOCK10 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 715908 | Benign: not provided | 224,805,210(-) | C/T | SYNONYMOUS_VARIANT | |
| 732361 | Benign: not provided | 224,874,723(-) | T/G | MISSENSE_VARIANT | |
| 783211 | Benign: not provided | 224,775,068(-) | G/A | SYNONYMOUS_VARIANT | |
| 785994 | Benign: not provided | 224,800,267(-) | T/C | INTRON_VARIANT | |
| 791895 | Benign: not provided | 224,773,259(-) | G/A | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.65;
91.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DOCK10 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK10 Gene
Disorders for DOCK10 Gene
Additional Disease Information for DOCK10
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for DOCK10 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOCK10 Gene
Publications for DOCK10 Gene
- Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. (PMID: 18499258) Yelo E … Parrado A (Molecular immunology 2008) 3 4 23
- Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. (PMID: 12432077) Côté JF … Vuori K (Journal of cell science 2002) 2 3 4
- Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes. (PMID: 21514340) Alcaraz-García MJ … Parrado A (Human immunology 2011) 3 4
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
ExternalLinks
Products for DOCK10 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DOCK10
- Origene Custom Protein Services for DOCK10
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DOCK10
- Browse OriGene Inhibitory RNA Products For DOCK10
- OriGene qPCR primer pairs for DOCK10
- OriGene CRISPR knockouts for DOCK10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DOCK10
- Sino Biological Human cDNA Clone for DOCK10
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for DOCK10
- Novus Biologicals proteins for DOCK10
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for DOCK10
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for DOCK10 (AFLGC-DOCK10)
- VectorBuilder Custom and pre-made DNA vectors for DOCK10 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for DOCK10 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for DOCK10 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for DOCK10 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for DOCK10
- antibodies-online: Show 10 available DOCK10 Antibodies ranked by validation data
- Compare Top DOCK10 Antibodies
- Quality Products:
- antibodies-online: Search results for available DOCK10 related products ranked by validation data
- antibodies-online: Search results for available DOCK10 related products ranked by validation data
- Horizon Cell Lines for DOCK10
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DOCK10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DOCK10
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DOCK10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DOCK10
Sources for DOCK10 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
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