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Aliases for DOCK10 Gene

Aliases for DOCK10 Gene

  • Dedicator Of Cytokinesis 10 2 3 5
  • Zizimin3 2 3
  • ZIZ3 3 4
  • Dopamine Receptor Interacting Protein 2 3
  • Dedicator Of Cytokinesis Protein 10 3
  • Nbla10300 3
  • Zizimin-3 4
  • KIAA0694 4
  • DRIP2 3

External Ids for DOCK10 Gene

Previous GeneCards Identifiers for DOCK10 Gene

  • GC02M225593
  • GC02M225832
  • GC02M225455
  • GC02M225338
  • GC02M217481

Summaries for DOCK10 Gene

Entrez Gene Summary for DOCK10 Gene

  • This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]

GeneCards Summary for DOCK10 Gene

DOCK10 (Dedicator Of Cytokinesis 10) is a Protein Coding gene. Among its related pathways are Regulation of CDC42 activity and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK9.

UniProtKB/Swiss-Prot for DOCK10 Gene

  • Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.

Gene Wiki entry for DOCK10 Gene

Additional gene information for DOCK10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOCK10 Gene

Genomics for DOCK10 Gene

GeneHancer (GH) Regulatory Elements for DOCK10 Gene

Promoters and enhancers for DOCK10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J225037 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 661.1 +2.1 2122 6.2 SIN3A BMI1 KLF5 ZNF335 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CREM DOCK10 NYAP2 CUL3 MIR4439
GH02J224943 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 672.1 +96.1 96072 6.9 HDGF CTCF PKNOX1 JUN EBF1 KLF5 IRF4 POLR2A EED ATF7 DOCK10 NYAP2 CUL3 PIR37983 MIR4439
GH02J224881 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 29.7 +158.1 158148 6 STAT5A BATF IRF4 RAD21 YY1 EGR1 ZNF143 RCOR1 FOS BCLAF1 DOCK10 PIR37983 GC02P224823
GH02J225009 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 17 +31.7 31671 2.8 CTCF JUN SP1 FOSL1 JUND POLR2A GLIS1 FOS FOSL2 MIR4439 DOCK10 NYAP2
GH02J224921 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +117.3 117292 8.1 HDGF PKNOX1 JUN BACH1 BMI1 BATF IRF4 EED ATF7 FOS DOCK10 NYAP2 CUL3 PIR37983 GC02P224823
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DOCK10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DOCK10 gene promoter:

Genomic Locations for DOCK10 Gene

Genomic Locations for DOCK10 Gene
chr2:224,765,090-225,042,613
(GRCh38/hg38)
Size:
277,524 bases
Orientation:
Minus strand
chr2:225,629,807-225,907,330
(GRCh37/hg19)

Genomic View for DOCK10 Gene

Genes around DOCK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOCK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOCK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOCK10 Gene

Proteins for DOCK10 Gene

  • Protein details for DOCK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BY6-DOC10_HUMAN
    Recommended name:
    Dedicator of cytokinesis protein 10
    Protein Accession:
    Q96BY6
    Secondary Accessions:
    • B3FL70
    • O75178
    • Q68DA4
    • Q9NW06
    • Q9NXI8

    Protein attributes for DOCK10 Gene

    Size:
    2186 amino acids
    Molecular mass:
    249531 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Zizim means spike in Hebrew.
    SequenceCaution:
    • Sequence=AAH15018.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA31669.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91022.1; Type=Frameshift; Positions=2133; Evidence={ECO:0000305}; Sequence=BAA91583.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH18316.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DOCK10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOCK10 Gene

Post-translational modifications for DOCK10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DOCK10 Gene

Domains & Families for DOCK10 Gene

Suggested Antigen Peptide Sequences for DOCK10 Gene

Graphical View of Domain Structure for InterPro Entry

Q96BY6

UniProtKB/Swiss-Prot:

DOC10_HUMAN :
  • The DHR-2 domain may mediate some GEF activity.
  • Belongs to the DOCK family.
Domain:
  • The DHR-2 domain may mediate some GEF activity.
Family:
  • Belongs to the DOCK family.
genes like me logo Genes that share domains with DOCK10: view

Function for DOCK10 Gene

Molecular function for DOCK10 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
UniProtKB/Swiss-Prot Induction:
Isoforms 1 and 2 are up-regulated in response to IL4 in B-cells but not T-cells.

Phenotypes From GWAS Catalog for DOCK10 Gene

Gene Ontology (GO) - Molecular Function for DOCK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005085 guanyl-nucleotide exchange factor activity IEA,ISS --
GO:0005488 binding IEA --
genes like me logo Genes that share ontologies with DOCK10: view
genes like me logo Genes that share phenotypes with DOCK10: view

Animal Models for DOCK10 Gene

MGI Knock Outs for DOCK10:
  • Dock10 Dock10<tm1a(EUCOMM)Hmgu>

Animal Model Products

miRNA for DOCK10 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOCK10 Gene

Localization for DOCK10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOCK10 Gene

Nucleus. Cytoplasm. Cell projection, dendritic spine.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOCK10 gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 2
cytosol 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DOCK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 18499258
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 18499258
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with DOCK10: view

Pathways & Interactions for DOCK10 Gene

genes like me logo Genes that share pathways with DOCK10: view

Pathways by source for DOCK10 Gene

1 BioSystems pathway for DOCK10 Gene

Gene Ontology (GO) - Biological Process for DOCK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001782 B cell homeostasis ISS --
GO:0002315 marginal zone B cell differentiation ISS --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0030334 regulation of cell migration IDA 18835169
GO:0043547 positive regulation of GTPase activity ISS --
genes like me logo Genes that share ontologies with DOCK10: view

No data available for SIGNOR curated interactions for DOCK10 Gene

Drugs & Compounds for DOCK10 Gene

(3) Drugs for DOCK10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DOCK10: view

Transcripts for DOCK10 Gene

mRNA/cDNA for DOCK10 Gene

(10) Selected AceView cDNA sequences:
(12) Additional mRNA sequences :
(12) REFSEQ mRNAs :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DOCK10 Gene

Dedicator of cytokinesis 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOCK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: -
SP3:

Relevant External Links for DOCK10 Gene

GeneLoc Exon Structure for
DOCK10
ECgene alternative splicing isoforms for
DOCK10

Expression for DOCK10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DOCK10 Gene

mRNA differential expression in normal tissues according to GTEx for DOCK10 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.6).

Protein differential expression in normal tissues from HIPED for DOCK10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.2), Lymph node (15.8), CD8 Tcells (6.9), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DOCK10 Gene



NURSA nuclear receptor signaling pathways regulating expression of DOCK10 Gene:

DOCK10

SOURCE GeneReport for Unigene cluster for DOCK10 Gene:

Hs.46578

mRNA Expression by UniProt/SwissProt for DOCK10 Gene:

Q96BY6-DOC10_HUMAN
Tissue specificity: Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.

Evidence on tissue expression from TISSUES for DOCK10 Gene

  • Nervous system(4.6)
  • Blood(4.3)
  • Bone marrow(4.3)
  • Intestine(4.2)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with DOCK10: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOCK10 Gene

Orthologs for DOCK10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DOCK10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOCK10 34 33
  • 99.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DOCK10 34 33
  • 91.73 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DOCK10 34 33
  • 90.88 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dock10 16 34 33
  • 87.44 (n)
rat
(Rattus norvegicus)
Mammalia Dock10 33
  • 87.41 (n)
oppossum
(Monodelphis domestica)
Mammalia DOCK10 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 84 (a)
OneToMany
-- 34
  • 78 (a)
OneToMany
-- 34
  • 73 (a)
OneToMany
chicken
(Gallus gallus)
Aves DOCK10 34 33
  • 78.37 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOCK10 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dock10 33
  • 71.93 (n)
zebrafish
(Danio rerio)
Actinopterygii dock10 34 33
  • 67.16 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 59 (a)
OneToOne
Species where no ortholog for DOCK10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOCK10 Gene

ENSEMBL:
Gene Tree for DOCK10 (if available)
TreeFam:
Gene Tree for DOCK10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DOCK10: view image

Paralogs for DOCK10 Gene

Paralogs for DOCK10 Gene

(9) SIMAP similar genes for DOCK10 Gene using alignment to 6 proteins:

  • DOC10_HUMAN
  • F8WB48_HUMAN
  • F8WE73_HUMAN
  • H0YFC5_HUMAN
  • H7C0I3_HUMAN
  • Q4ZG60_HUMAN
genes like me logo Genes that share paralogs with DOCK10: view

Variants for DOCK10 Gene

Sequence variations from dbSNP and Humsavar for DOCK10 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000042374 -- 224,923,105(-) G/A intron_variant
rs1000044143 -- 224,920,341(-) T/A intron_variant
rs1000050959 -- 224,791,444(-) G/T intron_variant
rs1000058239 -- 224,963,724(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000084773 -- 224,855,576(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DOCK10 Gene

Variant ID Type Subtype PubMed ID
dgv2351e59 CNV duplication 20981092
dgv631e201 CNV deletion 23290073
esv1010048 CNV insertion 20482838
esv1011163 CNV insertion 20482838
esv1631002 CNV deletion 17803354
esv2663234 CNV deletion 23128226
esv2668530 CNV deletion 23128226
esv2721534 CNV deletion 23290073
esv2721535 CNV deletion 23290073
esv3303983 CNV mobile element insertion 20981092
esv3309958 CNV mobile element insertion 20981092
esv3326171 CNV insertion 20981092
esv3392806 CNV insertion 20981092
esv3405152 CNV insertion 20981092
esv3561074 CNV deletion 23714750
esv3594478 CNV gain 21293372
esv3594480 CNV loss 21293372
esv3594481 CNV loss 21293372
esv3594482 CNV loss 21293372
esv4249 CNV loss 18987735
esv8487 CNV gain 19470904
nsv1073014 CNV deletion 25765185
nsv1076504 CNV duplication 25765185
nsv1116001 CNV insertion 24896259
nsv1116831 CNV deletion 24896259
nsv1125776 CNV deletion 24896259
nsv1129212 CNV insertion 24896259
nsv1138892 CNV deletion 24896259
nsv1138893 CNV deletion 24896259
nsv3185 CNV deletion 18451855
nsv470519 CNV gain 18288195
nsv473288 CNV novel sequence insertion 20440878
nsv508131 OTHER sequence alteration 20534489
nsv517969 CNV loss 19592680
nsv954202 CNV deletion 24416366

Variation tolerance for DOCK10 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.65; 91.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DOCK10 Gene

Human Gene Mutation Database (HGMD)
DOCK10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOCK10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK10 Gene

Disorders for DOCK10 Gene

Additional Disease Information for DOCK10

No disorders were found for DOCK10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOCK10 Gene

Publications for DOCK10 Gene

  1. Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. (PMID: 18499258) Yelo E … Parrado A (Molecular immunology 2008) 3 4 22 58
  2. Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. (PMID: 12432077) Côté JF … Vuori K (Journal of cell science 2002) 2 3 4 58
  3. Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes. (PMID: 21514340) Alcaraz-García MJ … Parrado A (Human immunology 2011) 3 4 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58

Products for DOCK10 Gene

Sources for DOCK10 Gene

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