Aliases for DOCK1 Gene
External Ids for DOCK1 Gene
Previous GeneCards Identifiers for DOCK1 Gene
This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
GeneCards Summary for DOCK1 Gene
DOCK1 (Dedicator Of Cytokinesis 1) is a Protein Coding gene. Diseases associated with DOCK1 include Chromosome 10Q26 Deletion Syndrome and Hemophagocytic Lymphohistiocytosis, Familial, 2. Among its related pathways are Development FGFR signaling pathway and Shigellosis. Gene Ontology (GO) annotations related to this gene include binding and heme binding. An important paralog of this gene is DOCK5.
UniProtKB/Swiss-Prot Summary for DOCK1 Gene
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152).