Aliases for DOC2A Gene
Aliases for DOC2A Gene
External Ids for DOC2A Gene
- HGNC: 2985
- Entrez Gene: 8448
- Ensembl: ENSG00000149927
- OMIM: 604567
- UniProtKB: Q14183
Previous GeneCards Identifiers for DOC2A Gene
- GC16P029137
- GC16M030339
- GC16M030015
- GC16M030054
- GC16M029924
- GC16M030016
- GC16M027677
- GC16M030019
- GC16M030017
Summaries for DOC2A Gene
-
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for DOC2A Gene
DOC2A (Double C2 Domain Alpha) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is DOC2B.
UniProtKB/Swiss-Prot for DOC2A Gene
-
Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOC2A Gene
Genomics for DOC2A Gene
GeneHancer (GH) Regulatory Elements for DOC2A Gene
Promoters and enhancers for DOC2A Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH16J030008 | Promoter | 1.7 | EPDnew Ensembl | 600.4 | +12.0 | 11979 | 1.4 | ZBTB7A SP7 KLF14 GLIS2 PRDM10 ZIC2 TARDBP RFX1 ZSCAN4 KLF7 | DOC2A YPEL3 INO80E ZNF785 SRCAP SMG1P2 SMG1P5 SLX1A ZNF764 BCL7C | |
| GH16J030020 | Promoter/Enhancer | 1.6 | Ensembl ENCODE | 600.7 | +1.9 | 1879 | 1.6 | HDGF SP1 CC2D1A ELF3 CTCF MNT ZNF121 ZSCAN21 AHR MAFK | DOC2A GC16P030021 C16orf92 SETD1A SRCAP INO80E ZNF764 YPEL3 ZNF785 BCL7C | |
| GH16J030012 | Promoter | 0.6 | EPDnew | 600.4 | +10.9 | 10931 | 0.1 | ZNF473 | DOC2A ZNF689 ZNF688 NPIPB10P MIR762HG LOC730183 PHKG2 SETD1A FBRS GC16P030017 | |
| GH16J030022 | Enhancer | 0.2 | Ensembl | 600.7 | +0.6 | 579 | 0.2 | C16orf92 DOC2A GC16P030021 | ||
| GH16J030051 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE dbSUPER | 12.1 | -30.1 | -30136 | 4.6 | MTA3 CC2D1A ZFX SP1 ELF3 CTCF MNT NKRF ZNF121 CEBPG | ALDOA TLCD3B LOC112694756 SETD1A SRCAP NPIPB12 INO80E ZNF764 NPIPB13 ZNF747 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DOC2A on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DOC2A gene promoter:
-
- AREB6
- ARP-1
- C/EBPalpha
- CHOP-10
- Egr-3
- Evi-1
- GR
- GR-alpha
- GR-beta
- RORalpha1
Genomic Locations for DOC2A Gene
Genomic Locations for DOC2A Gene
- chr16:30,005,514-30,023,280
- (GRCh38/hg38)
- Size:
- 17,767 bases
- Orientation:
- Minus strand
- chr16:30,016,830-30,034,591
- (GRCh37/hg19)
- Size:
- 17,762 bases
- Orientation:
- Minus strand
Genomic View for DOC2A Gene
Genes around DOC2A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by HGNC
- 16p11.2 by Entrez Gene
- 16p11.2 by Ensembl
DOC2A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DOC2A Gene
Proteins for DOC2A Gene
-
Protein details for DOC2A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14183-DOC2A_HUMAN
- Recommended name:
- Double C2-like domain-containing protein alpha
- Protein Accession:
- Q14183
- B4DEJ2
- H3BNH6
- Q6P4G4
- Q7Z5G0
- Q8IVX0
Protein attributes for DOC2A Gene
- Size:
- 400 amino acids
- Molecular mass:
- 43959 Da
- Quaternary structure:
-
- Interacts (via N-terminus) with UNC13A. Interacts with cytoplasmic dynein light chain DYNLT1. Interacts with UNC13D.
Protein Expression for DOC2A Gene
Post-translational modifications for DOC2A Gene
Other Protein References for DOC2A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-DOC2A Antibody
-
Custom Antibody ServicesOriGene Antibodies for DOC2A
- Novus Biologicals Antibodies for DOC2A
-
Abcam antibodies for DOC2A
- Invitrogen Antibodies for DOC2A (AFLGC-DOC2A)
Protein Products
- Atlas Antibodies PrEST Antigen DOC2A
-
OriGene Purified Proteins for DOC2A
- Search Origene for MassSpec and Protein Over-expression Lysates for DOC2A
- Origene Custom Protein Services for DOC2A
- Novus Biologicals proteins for DOC2A
-
Abcam proteins for DOC2A
No data available for DME Specific Peptides for DOC2A Gene
Domains & Families for DOC2A Gene
Gene Families for DOC2A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for DOC2A Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DOC2A Gene
- GenScript: Design optimal peptide antigens:
-
- Double C2-like domain-containing protein alpha (DOC2A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q14183- Domain:
-
- C2 domain 1 is involved in binding calcium and phospholipids.
Function for DOC2A Gene
Molecular function for DOC2A Gene
- UniProtKB/Swiss-Prot Function:
- Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
Phenotypes From GWAS Catalog for DOC2A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 18354201 |
| GO:0005544 | calcium-dependent phospholipid binding | IEA | -- |
Phenotypes for DOC2A Gene
- MGI mutant phenotypes for DOC2A:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DOC2A:
Animal Models for DOC2A Gene
- MGI Knock Outs for DOC2A:
-
- Doc2a Doc2a<tm1Ytk>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DOC2A
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DOC2A - Now 50% OFF >
- * DOC2A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for DOC2A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DOC2A
- genomics-online: gRNA clones - Search results for 91 available DOC2A gene related products
- Overview of 91 available DOC2A gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for DOC2A
miRNA Products
Inhibitory RNA Products
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- Overview of 91 available DOC2A gene related products
Clone Products
- Applied Biological Materials (abm): Clones for DOC2A - Now 50% OFF >
- * DOC2A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * DOC2A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG206372
- MR206372
- MR206372L1
- MR206372L1V
- MR206372L2
- MR206372L2V
- MR206372L3
- MR206372L3V
- MR206372L4
- MR206372L4V
- RC208788
- RC208788L1
- RC208788L1V
- RC208788L2
- RC208788L2V
- RC208788L3
- RC208788L3V
- RC208788L4
- RC208788L4V
- RC237984
- RC237985
- RC237986
- RG208788
- RR214667
- RR214667L1
- RR214667L1V
- RR214667L2
- RR214667L2V
- RR214667L3
- RR214667L3V
- RR214667L4
- RR214667L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DOC2A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DOC2A
Cell Line Products
-
Horizon Cell Lines for DOC2A
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DOC2A Gene
Localization for DOC2A Gene
Subcellular locations from UniProtKB/Swiss-Prot for DOC2A Gene
- Lysosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Note=Colocalizes to synaptic vesicles.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 3 |
| lysosome | 3 |
| plasma membrane | 1 |
| mitochondrion | 1 |
- Cell Junctions (1)
- Nucleoli (1)
- Nucleus (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005764 | lysosome | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0030054 | cell junction | IEA,IDA | -- |
Pathways & Interactions for DOC2A Gene
Interacting Proteins for DOC2A Gene
GPS-Prot Interaction Network for DOC2A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006887 | exocytosis | IEA | -- |
| GO:0007268 | chemical synaptic transmission | TAS | 7826360 |
| GO:0007399 | nervous system development | TAS | 7826360 |
| GO:0016079 | synaptic vesicle exocytosis | IEA | -- |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | IMP | 18354201 |
No data available for Pathways by source and SIGNOR curated interactions for DOC2A Gene
Drugs & Compounds for DOC2A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Calcium | Approved | Nutra | 7611 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Atlas Antibodies PrEST Antigen DOC2A
Transcripts for DOC2A Gene
mRNA/cDNA for DOC2A Gene
- (4) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (84) Selected AceView cDNA sequences:
- (18) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000350119 2013 bps (ENST00000350119.8)
- ENST00000564233 3749 bps (ENST00000564233.5)
- ENST00000564357 1254 bps (ENST00000564357.5)
- ENST00000564944 1782 bps (ENST00000564944.5)
- ENST00000564979 1630 bps (ENST00000564979.5)
Unigene Clusters for DOC2A Gene
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DOC2A - Now 50% OFF >
- * DOC2A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * DOC2A CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for DOC2A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DOC2A
- genomics-online: gRNA clones - Search results for 91 available DOC2A gene related products
- Overview of 91 available DOC2A gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for DOC2A
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DOC2A
- Browse OriGene Inhibitory RNA Products For DOC2A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DOC2A
- genomics-online: shRNA clones - Search results for 91 available DOC2A gene related products
- Overview of 91 available DOC2A gene related products
Clone Products
- Applied Biological Materials (abm): Clones for DOC2A - Now 50% OFF >
- * DOC2A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * DOC2A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG206372
- MR206372
- MR206372L1
- MR206372L1V
- MR206372L2
- MR206372L2V
- MR206372L3
- MR206372L3V
- MR206372L4
- MR206372L4V
- RC208788
- RC208788L1
- RC208788L1V
- RC208788L2
- RC208788L2V
- RC208788L3
- RC208788L3V
- RC208788L4
- RC208788L4V
- RC237984
- RC237985
- RC237986
- RG208788
- RR214667
- RR214667L1
- RR214667L1V
- RR214667L2
- RR214667L2V
- RR214667L3
- RR214667L3V
- RR214667L4
- RR214667L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DOC2A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DOC2A
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||
| SP7: |
Expression for DOC2A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Adult Dopaminergic Neurons Ventral Tegmental Area
- Hypothalamus
- Hippocampus
- Thalamus
- Cerebellum
-
Neurons
- Adult Dopaminergic Neurons Ventral Tegmental Area
- Kidney (Urinary System)
- Epiblast (Early Embryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for DOC2A Gene
This gene is overexpressed in Brain - Cortex (x7.8), Brain - Frontal Cortex (BA9) (x6.5), Brain - Anterior cingulate cortex (BA24) (x5.4), Brain - Cerebellum (x4.5), and Brain - Cerebellar Hemisphere (x4.1).
This gene is overexpressed in Frontal cortex (61.1) and Fetal Brain (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DOC2A Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DOC2A Gene:
DOC2ASOURCE GeneReport for Unigene cluster for DOC2A Gene:
Hs.355281mRNA Expression by UniProt/SwissProt for DOC2A Gene:
Q14183-DOC2A_HUMAN
Tissue specificity:
Predominantly expressed in brain. Also expressed in testis.
Evidence on tissue expression from TISSUES for DOC2A Gene
- Nervous system(4.7)
Primer Products
-
OriGene qPCR primer pairs for DOC2A
-
OriGene qPCR primer pairs and template standards for DOC2A
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DOC2A Gene
Orthologs for DOC2A Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DOC2A 35 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DOC2A 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DOC2A 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Doc2a 17 35 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | DOC2A 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Doc2a 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DOC2A 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DOC2A 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | si:dkey-93n13.3 34 |
|
||
| DOC2A 35 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | rabphilin-3A 36 |
|
|
|
| Rph 35 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | rbf-1 35 |
|
OneToMany |
- Species where no ortholog for DOC2A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for DOC2A Gene
- ENSEMBL:
- Gene Tree for DOC2A (if available)
- TreeFam:
- Gene Tree for DOC2A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DOC2A: view image
Paralogs for DOC2A Gene
Paralogs for DOC2A Gene
(15) SIMAP similar genes for DOC2A Gene using alignment to 9 proteins:
- DOC2A_HUMAN
- B4DEJ2_HUMAN
- H3BNF7_HUMAN
- H3BSH4_HUMAN
- H3BSN9_HUMAN
- H3BTI1_HUMAN
- H3BU41_HUMAN
- I3L194_HUMAN
- I3L3P9_HUMAN
Variants for DOC2A Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000037841 | -- | 30,010,428(-) | G/T | 5_prime_UTR_variant, intron_variant | |
| rs1000108327 | -- | 30,019,114(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000241646 | -- | 30,021,255(-) | G/T | 5_prime_UTR_variant, genic_upstream_transcript_variant | |
| rs1000318863 | -- | 30,024,907(-) | C/T | upstream_transcript_variant | |
| rs1000516839 | -- | 30,007,096(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3638378 | CNV | loss | 21293372 |
Residual Variation Intolerance Score:
68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.06;
80.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DOC2A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOC2A Gene
Disorders for DOC2A Gene
Additional Disease Information for DOC2A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for DOC2A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOC2A Gene
Publications for DOC2A Gene
- Doc2: a novel brain protein having two repeated C2-like domains. (PMID: 7826360) Orita S … Takai Y (Biochemical and biophysical research communications 1995) 2 3 4 23 58
- Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells. (PMID: 18354201) Higashio H … Sasaki T (Journal of immunology (Baltimore, Md. : 1950) 2008) 3 4 23 58
- Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter release process. (PMID: 9736751) Mochida S … Takai Y (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 58
- Molecular cloning of an isoform of Doc2 having two C2-like domains. (PMID: 8554557) Sakaguchi G … Takai Y (Biochemical and biophysical research communications 1995) 3 4 23 58
- Strong synaptic transmission impact by copy number variations in schizophrenia. (PMID: 20489179) Glessner JT … Hakonarson H (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 45 58
ExternalLinks
Products for DOC2A Gene
- Custom Antibody ServicesOriGene Antibodies for DOC2A
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- Browse OriGene Inhibitory RNA Products For DOC2A
- OriGene qPCR primer pairs for DOC2A
- OriGene qPCR primer pairs and template standards for DOC2A
- OriGene CRISPR knockouts for DOC2A
- MG206372
- MR206372
- MR206372L1
- MR206372L1V
- MR206372L2
- MR206372L2V
- MR206372L3
- MR206372L3V
- MR206372L4
- MR206372L4V
- RC208788
- RC208788L1
- RC208788L1V
- RC208788L2
- RC208788L2V
- RC208788L3
- RC208788L3V
- RC208788L4
- RC208788L4V
- RC237984
- RC237985
- RC237986
- RG208788
- RR214667
- RR214667L1
- RR214667L1V
- RR214667L2
- RR214667L2V
- RR214667L3
- RR214667L3V
- RR214667L4
- RR214667L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DOC2A
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- Novus Biologicals proteins for DOC2A
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Abcam antibodies for DOC2A
- Abcam proteins for DOC2A
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- Invitrogen Antibodies for DOC2A (AFLGC-DOC2A)
- Cyagen custom Knockout/knockin (KOKI) mouse models for DOC2A
- antibodies-online: Search results for 43 available DOC2A Antibodies ranked by validation data
- Compare Top DOC2A Antibodies
- antibodies-online: Search results for available DOC2A related products ranked by validation data
- antibodies-online: Search results for 4 available DOC2A Proteins ranked by validation data
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- Horizon Cell Lines for DOC2A
- genomics-online: cdna clones - Search results for 91 available DOC2A gene related products
- Overview of 91 available DOC2A gene related products
- orf clones - Search results for 91 available DOC2A gene related products
- Overview of 91 available DOC2A gene related products
- genomics-online: gRNA clones - Search results for 91 available DOC2A gene related products
- Overview of 91 available DOC2A gene related products
- genomics-online: primer clones - Search results for 91 available DOC2A gene related products
- Overview of 91 available DOC2A gene related products
- genomics-online: shRNA clones - Search results for 91 available DOC2A gene related products
- Overview of 91 available DOC2A gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DOC2A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DOC2A
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DOC2A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DOC2A
Sources for DOC2A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) HGMD
- (45) GAD
- (46) BGMUT
- (47) HuGE
- (48) Atlas
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) OCA
- (69) Proteopedia
- (70) MOPED
- (71) neXtProt
- (72) Reactome
- (73) GeneGo (Thomson Reuters)
- (74) fRNAdb
- (75) DISEASES
- (76) SIMAP
- (77) GenomeRNAi
- (78) LifeMap
- (79) miRTarBase
- (80) MalaCards
- (81) Invitrogen
- (82) BitterDB
- (83) ESI-BIO
- (84) RefSeq
- (85) BioSystems
- (86) MaxQB
- (87) IUPHAR
- (88) BioGPS
- (89) Illumina
- (90) COMPARTMENTS
- (91) HOMER
- (92) PaxDb
- (93) ApexBio
- (94) Addgene
- (95) antibodies-online
- (96) CYP
- (97) NONCODE
- (98) SwitchGear Genomics
- (99) TreeFam
- (100) PathCards
- (101) GeneReviews
- (102) GeneTex
- (103) Taconic Biosciences
- (104) GTEx
- (105) ProteomicsDB
- (106) SCBT
- (107) DGIdb
- (108) ClinicalTrials
- (109) FDA Approved Drugs
- (110) RVIS
- (111) SIGNOR
- (112) diseasecard
- (113) NIH Rare Diseases
- (114) Orphanet
- (115) UMLS
- (116) GTR
- (117) Disease Ontology
- (118) Genetics Home Reference
- (119) MeSH
- (120) MedlinePlus
- (121) CDC
- (122) NINDS
- (123) NCBI Bookshelf
- (124) ClinVar
- (125) Gene Damage Index
- (126) ViGene Biosciences
- (127) HPO
- (128) UDN
- (129) VISTA
- (130) FANTOM5
- (131) ENCODE
- (132) ProSci
- (133) Horizon
- (134) NURSA
- (135) IID
- (136) Cyagen
- (137) VectorBuilder
- (138) SNPedia
- (139) BRCA Exchange
- (140) St John's Lab
- (141) CIViC
- (142) ProteoGenix
- (143) dbSUPER
- (144) TISSUES
- (145) Gene ORGANizer
- (146) abm
- (147) CrownBio
- (148) Human Protein Atlas
- (149) GWAS Catalog
- (150) Monarch Initiative
- (151) DataMed
- (152) HumanCyc
- (153) genomics-online
- (154) UCNEbase
- (155) EPDnew
- (156) Applied Biosystems
- (157) GlyConnect
- (158) Aminode
- (159) GeneCopoeia
- (160) GPS-Prot
- (161) RNACentral
- (162) LncRNADisease
- (163) LOVD
- (164) miR2Disease
- (165) DiseaseEnhancer
- (166) Boster Bio
- (167) Biorbyt
- (168) Biocompare
- (169) Mastermind