Aliases for DNTT Gene
External Ids for DNTT Gene
Previous GeneCards Identifiers for DNTT Gene
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for DNTT Gene
DNTT (DNA Nucleotidylexotransferase) is a Protein Coding gene. Diseases associated with DNTT include Myeloid Sarcoma and Lymphoblastic Lymphoma. Among its related pathways are Validated targets of C-MYC transcriptional repression and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include DNA-directed DNA polymerase activity and DNA polymerase activity. An important paralog of this gene is POLM.
UniProtKB/Swiss-Prot Summary for DNTT Gene
Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.