Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
DNPEP (Aspartyl Aminopeptidase) is a Protein Coding gene. Diseases associated with DNPEP include Nemaline Myopathy 9 and Tarsal-Carpal Coalition Syndrome. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and aminopeptidase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004177 | aminopeptidase activity | IEA,TAS | 9632644 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008237 | metallopeptidase activity | IEA | -- |
GO:0008270 | zinc ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | HDA | 21630459 |
GO:0005737 | cytoplasm | TAS | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0072562 | blood microparticle | HDA | 22516433 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA | -- |
GO:0006518 | peptide metabolic process | TAS | 9632644 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Glutamic acid | Approved | Nutra | Agonist, Full agonist, Target | 304 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - |
ExUns: | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||
SP2: | |||||||||||
SP3: | |||||||||||
SP4: | |||||||||||
SP5: | |||||||||||
SP6: | |||||||||||
SP7: | |||||||||||
SP8: | |||||||||||
SP9: | |||||||||||
SP10: | |||||||||||
SP11: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DNPEP 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DNPEP 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DNPEP 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dnpep 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Dnpep 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DNPEP 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DNPEP 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DNPEP 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dnpep 30 |
|
||
Str.2142 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.20819 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dnpep 30 31 |
|
OneToOne | |
zgc55944 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10876 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | dnpp-1 30 31 |
|
OneToOne | |
F01F1.9 32 |
|
|
|||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E21297g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | APE4 30 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G60160 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.1803 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os12g0236500 30 |
|
||
Os.16710 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.1571 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.7128 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU00122 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10534 31 |
|
OneToOne | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | aap1 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1126577 | CNV | deletion | 24896259 |
nsv834543 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
nemaline myopathy 9 |
|
|
tarsal-carpal coalition syndrome |
|
|
nemaline myopathy 8 |
|
|
nemaline myopathy 11, autosomal recessive |
|
|
nemaline myopathy 10 |
|
|