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DNPEP Gene(Protein Coding)

Aspartyl Aminopeptidase

GCID:
GC02M219373
GIFtS:
46
Genes Participants
UDN Logo

Aliases for DNPEP Gene

Aliases for DNPEP Gene

  • Aspartyl Aminopeptidase 2 3 5
  • EC 3.4.11.21 4 56
  • ASPEP 3 4
  • DAP 3 4

External Ids for DNPEP Gene

Previous GeneCards Identifiers for DNPEP Gene

  • GC02M218261
  • GC02M218959
  • GC02M220201
  • GC02M220440
  • GC02M220063
  • GC02M219946
  • GC02M220238
  • GC02M212091

Summaries for DNPEP Gene

Entrez Gene Summary for DNPEP Gene

  • The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for DNPEP Gene

DNPEP (Aspartyl Aminopeptidase) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and aminopeptidase activity.

UniProtKB/Swiss-Prot for DNPEP Gene

  • Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.

Gene Wiki entry for DNPEP Gene

Additional gene information for DNPEP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNPEP Gene

Genomics for DNPEP Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for DNPEP Gene

Promoters and enhancers for DNPEP Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02I219386 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 562.5 +12.1 12062 3.4 ARID4B SIN3A DMAP1 YY1 ZNF213 ZNF207 ZNF143 SP3 SP5 JUNB DNPEP LOC105373884 NHEJ1 ANKZF1 DES SLC23A3 GMPPA BCS1L CNOT9 USP37
GH02I219397 Enhancer 1.3 Ensembl ENCODE dbSUPER 561.5 +1.0 994 3.7 PKNOX1 ATF1 FOXA2 FEZF1 YY1 ATF7 FOS REST ZNF592 MEF2D DNPEP OBSL1 ENSG00000269068 ENSG00000268896 ASIC4 ENSG00000227432 ENSG00000268603 SPEG GMPPA CHPF
GH02I219594 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.3 -196.9 -196881 4.3 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B STK11IP NHEJ1 DNPEP RN7SKP213
GH02I219227 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.3 +170.4 170414 3.4 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ANKZF1 ATG9A USP37 NHEJ1 DNPEP GLB1L ABCB6 AAMP CNOT9 TUBA4B
GH02I219569 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.1 -171.5 -171509 4 PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 INHA OBSL1 ZNF142 RNF25 NHEJ1 SLC23A3 STK36 STK11IP GLB1L DNPEP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DNPEP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNPEP gene promoter:

Genomic Locations for DNPEP Gene

Genomic Locations for DNPEP Gene
chr2:219,373,458-219,400,022
(GRCh38/hg38)
Size:
26,565 bases
Orientation:
Minus strand
chr2:220,238,180-220,264,744
(GRCh37/hg19)

Genomic View for DNPEP Gene

Genes around DNPEP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNPEP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNPEP Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DNPEP Gene

Proteins for DNPEP Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DNPEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULA0-DNPEP_HUMAN
    Recommended name:
    Aspartyl aminopeptidase
    Protein Accession:
    Q9ULA0
    Secondary Accessions:
    • Q9BW44
    • Q9NUV5
    • Q9NV55

    Protein attributes for DNPEP Gene

    Size:
    475 amino acids
    Molecular mass:
    52428 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Tetrahedron-shaped homododecamer built from six homodimers.
    SequenceCaution:
    • Sequence=BAA91903.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91903.1; Type=Frameshift; Positions=398; Evidence={ECO:0000305}; Sequence=BAA92014.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNPEP Gene

neXtProt entry for DNPEP Gene

Protein Expression for DNPEP Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for DNPEP Gene

Q9ULA0:
  • QEELEKGTPEPGPL
  • KHEENHRP
  • AMHSIRE
  • FHKGPVIKVNSKQRYASNAVSE
  • RPILRIPHLAIHLQRN
  • SADMAHA
  • GAHTDSP
  • TAFEEAI
  • NENFGPN
  • QVGVETYGG

Post-translational modifications for DNPEP Gene

No Post-translational modifications

Other Protein References for DNPEP Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DNPEP Gene

Gene Families for DNPEP Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DNPEP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DNPEP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULA0

UniProtKB/Swiss-Prot:

DNPEP_HUMAN :
  • Belongs to the peptidase M18 family.
Family:
  • Belongs to the peptidase M18 family.
genes like me logo Genes that share domains with DNPEP: view

Function for DNPEP Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for DNPEP Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.
UniProtKB/Swiss-Prot EnzymeRegulation:
One of the zinc ions is readily exchangeable with other divalent cations such as manganese, which strongly stimulates the enzymatic activity.
UniProtKB/Swiss-Prot Function:
Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.

Enzyme Numbers (IUBMB) for DNPEP Gene

Phenotypes From GWAS Catalog for DNPEP Gene

Gene Ontology (GO) - Molecular Function for DNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity TAS 9632644
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with DNPEP: view
genes like me logo Genes that share phenotypes with DNPEP: view

Animal Model Products

Clone Products

  • Addgene plasmids for DNPEP

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNPEP Gene

Localization for DNPEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNPEP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNPEP gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,HDA 21630459
GO:0005737 cytoplasm TAS,IBA --
GO:0005829 cytosol IDA --
GO:0072562 blood microparticle HDA,IDA 22516433
genes like me logo Genes that share ontologies with DNPEP: view

Pathways & Interactions for DNPEP Gene

SuperPathways for DNPEP Gene

PathCards logo More details on SuperPathways for DNPEP
No Data Available

Gene Ontology (GO) - Biological Process for DNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process TAS 9632644
genes like me logo Genes that share ontologies with DNPEP: view

No data available for Pathways by source and SIGNOR curated interactions for DNPEP Gene

Drugs & Compounds for DNPEP Gene

Products:

  1. Drug

(1) Drugs for DNPEP Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic Acid Approved Nutra Full agonist, Agonist, Target 251
genes like me logo Genes that share compounds with DNPEP: view

Transcripts for DNPEP Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DNPEP Gene

(8) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(445) Selected AceView cDNA sequences:
(21) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNPEP Gene

Aspartyl aminopeptidase:
Representative Sequences:

Clone Products

  • Addgene plasmids for DNPEP

Alternative Splicing Database (ASD) splice patterns (SP) for DNPEP Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - -
SP7: -
SP8:
SP9:
SP10:
SP11: -

ExUns: 15b ^ 16a · 16b · 16c ^ 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for DNPEP Gene

GeneLoc Exon Structure for
DNPEP
ECgene alternative splicing isoforms for
DNPEP

Expression for DNPEP Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNPEP Gene

mRNA expression in normal human tissues for DNPEP Gene
mRNA expression by GTEx for DNPEP GenemRNA expression by BioGPS for DNPEP Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNPEP Gene



Protein tissue co-expression partners for DNPEP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNPEP Gene:

DNPEP

SOURCE GeneReport for Unigene cluster for DNPEP Gene:

Hs.258551

mRNA Expression by UniProt/SwissProt for DNPEP Gene:

Q9ULA0-DNPEP_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DNPEP Gene

  • Liver(4.5)
  • Eye(4.2)
  • Nervous system(3.8)
  • Kidney(3)
  • Intestine(2.9)
  • Thyroid gland(2.6)
  • Adrenal gland(2.3)
  • Gall bladder(2.3)
  • Lung(2.3)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with DNPEP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNPEP Gene

Orthologs for DNPEP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNPEP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia DNPEP 33 34
  • 99.09 (n)
dog
(Canis familiaris)
 Mammalia DNPEP 33 34
  • 89.59 (n)
cow
(Bos Taurus)
 Mammalia DNPEP 33 34
  • 89.53 (n)
rat
(Rattus norvegicus)
 Mammalia Dnpep 33
  • 86.53 (n)
mouse
(Mus musculus)
 Mammalia Dnpep 33 16 34
  • 86.46 (n)
oppossum
(Monodelphis domestica)
 Mammalia DNPEP 34
  • 75 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves DNPEP 33 34
  • 74.8 (n)
lizard
(Anolis carolinensis)
 Reptilia DNPEP 34
  • 61 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia dnpep 33
  • 70.24 (n)
Str.2142 33
African clawed frog
(Xenopus laevis)
 Amphibia Xl.20819 33
zebrafish
(Danio rerio)
 Actinopterygii dnpep 33 34
  • 68.03 (n)
zgc55944 33
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.10876 33
worm
(Caenorhabditis elegans)
 Secernentea dnpp-1 33 34
  • 55.51 (n)
F01F1.9 35
  • 50 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0E21297g 33
  • 51.1 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes APE4 33 34 36
  • 49.41 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT5G60160 33
  • 54.24 (n)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.1803 33
rice
(Oryza sativa)
 Liliopsida Os12g0236500 33
  • 54.57 (n)
Os.16710 33
barley
(Hordeum vulgare)
 Liliopsida Hv.1571 33
wheat
(Triticum aestivum)
 Liliopsida Ta.7128 33
bread mold
(Neurospora crassa)
 Ascomycetes NCU00122 33
  • 57.52 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.10534 34
  • 54 (a)
 OneToOne
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes aap1 33
  • 49.56 (n)
Species where no ortholog for DNPEP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNPEP Gene

ENSEMBL:
Gene Tree for DNPEP (if available)
TreeFam:
Gene Tree for DNPEP (if available)

Paralogs for DNPEP Gene

No data available for Paralogs for DNPEP Gene

Variants for DNPEP Gene

Sequence variations from dbSNP and Humsavar for DNPEP Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000186868 -- 219,400,070(-) T/G upstream_transcript_variant
rs1000288318 -- 219,399,979(-) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000337377 -- 219,393,679(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000361531 -- 219,399,703(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000384700 -- 219,400,333(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DNPEP Gene

Variant ID Type Subtype PubMed ID
nsv1126577 CNV deletion 24896259
nsv834543 CNV loss 17160897

Variation tolerance for DNPEP Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNPEP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNPEP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNPEP Gene

Disorders for DNPEP Gene

Additional Disease Information for DNPEP

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DNPEP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNPEP Gene

Publications for DNPEP Gene

  1. Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase. (PMID: 9632644) Wilk S … Magnusson RP (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family. (PMID: 22720794) Chaikuad A … Yue WW (BMC structural biology 2012) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase. (PMID: 12413488) Wilk S … Magnusson RP (Archives of biochemistry and biophysics 2002) 3 22 58

Products for DNPEP Gene

  • Addgene plasmids for DNPEP

Sources for DNPEP Gene

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