Aliases for DNM3 Gene
External Ids for DNM3 Gene
Previous GeneCards Identifiers for DNM3 Gene
This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
GeneCards Summary for DNM3 Gene
DNM3 (Dynamin 3) is a Protein Coding gene. Diseases associated with DNM3 include Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, And Neuropathy and Centronuclear Myopathy. Among its related pathways are Endocytic Trafficking of EGFR and Notch Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is DNM2.
UniProtKB/Swiss-Prot Summary for DNM3 Gene
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity).
GTPases are a group of enzymes that catalyze hydrolysis of the gamma phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ ions are essential for catalytic activity. GTPases, often coupled to G proteins, are essential in signal transduction.