Aliases for DNM3 Gene
External Ids for DNM3 Gene
Previous GeneCards Identifiers for DNM3 Gene
This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
GeneCards Summary for DNM3 Gene
DNM3 (Dynamin 3) is a Protein Coding gene. Diseases associated with DNM3 include Autosomal Dominant Optic Atrophy Plus Syndrome. Among its related pathways are Vesicle-mediated transport and RET signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is DNM2.
UniProtKB/Swiss-Prot Summary for DNM3 Gene
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity).
GTPases are a group of enzymes that catalyze hydrolysis of the gamma phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ ions are essential for catalytic activity. GTPases, often coupled to G proteins, are essential in signal transduction.