Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNLZ Gene

Aliases for DNLZ Gene

  • DNL-Type Zinc Finger 2 3 5
  • Hsp70-Escort Protein 1 3 4
  • MtHsp70-Escort Protein 3 4
  • HSP70 Escort Protein 2 3
  • C9orf151 3 4
  • HEP1 3 4
  • Translocase Of Inner Mitochondrial Membrane 15 Homolog (Yeast) 2
  • Translocase Of Inner Mitochondrial Membrane 15 Homolog 3
  • Chromosome 9 Open Reading Frame 151 2
  • DNL-Type Zinc Finger Protein 3
  • RP11-413M3.2 3
  • BA413M3.2 3
  • TIMM15 3
  • ZIM17 3
  • HEP 3

External Ids for DNLZ Gene

Previous HGNC Symbols for DNLZ Gene

  • C9orf151

Previous GeneCards Identifiers for DNLZ Gene

  • GC09M138380
  • GC09M139253
  • GC09M108715

Summaries for DNLZ Gene

GeneCards Summary for DNLZ Gene

DNLZ (DNL-Type Zinc Finger) is a Protein Coding gene. Diseases associated with DNLZ include Candidiasis, Familial, 2 and Familial Candidiasis. Gene Ontology (GO) annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot for DNLZ Gene

  • May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.

Additional gene information for DNLZ Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNLZ Gene

Genomics for DNLZ Gene

GeneHancer (GH) Regulatory Elements for DNLZ Gene

Promoters and enhancers for DNLZ Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J136358 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 694.9 +2.2 2210 5.5 HDGF SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B DNLZ RABL6 INPP5E ANAPC2 MAN1B1 SNAPC4 SNHG7 NPDC1 ENTR1 CARD9
GH09J136365 Enhancer 0.6 ENCODE 690 -1.7 -1731 1.3 NFIA NFIB ZNF121 GLIS2 NFIC POLR2A VEZF1 ZNF341 ZSCAN29 RCOR1 DNLZ INPP5E PMPCA ENTR1 CARD9 GC09M136338
GH09J136364 Enhancer 0.5 ENCODE 650.7 -0.6 -633 0.2 HIC1 CTCF ZNF639 POLR2A RBM22 ZBTB33 ZNF2 DNLZ CARD9 GC09M136338
GH09J136398 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 39.1 -36.0 -36010 3 HDGF ARID4B SIN3A ZNF766 ZNF207 ZNF143 DEK REST ZNF592 KAT8 SNAPC4 INPP5E DNLZ ENTR1 ANAPC2 CARD9 SEC16A FAM69B TRAF2
GH09J136408 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 37 -46.6 -46642 3.6 HDGF CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ENTR1 GC09M136410 PMPCA PIR36061 PIR60193 INPP5E DNLZ SEC16A SNAPC4 SNHG7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DNLZ on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNLZ gene promoter:
  • NF-kappaB
  • NF-kappaB1
  • PPAR-gamma2
  • PPAR-gamma1
  • c-Ets-1
  • SREBP-1a
  • Pax-6
  • NF-1
  • SREBP-1b
  • SREBP-1c

Genomic Locations for DNLZ Gene

Genomic Locations for DNLZ Gene
4,332 bases
Minus strand
4,310 bases
Minus strand

Genomic View for DNLZ Gene

Genes around DNLZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNLZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNLZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNLZ Gene

Proteins for DNLZ Gene

  • Protein details for DNLZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNL-type zinc finger protein
    Protein Accession:
    Secondary Accessions:
    • B2RUX5
    • B9EJE1

    Protein attributes for DNLZ Gene

    178 amino acids
    Molecular mass:
    19204 Da
    Quaternary structure:
    • Oligomerizes in a concentration-dependent fashion. Interacts with HSPA9.

neXtProt entry for DNLZ Gene

Post-translational modifications for DNLZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNLZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNLZ Gene

Domains & Families for DNLZ Gene

Gene Families for DNLZ Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DNLZ Gene


Suggested Antigen Peptide Sequences for DNLZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNLZ: view

No data available for UniProtKB/Swiss-Prot for DNLZ Gene

Function for DNLZ Gene

Molecular function for DNLZ Gene

UniProtKB/Swiss-Prot Function:
May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.

Phenotypes From GWAS Catalog for DNLZ Gene

Gene Ontology (GO) - Molecular Function for DNLZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0051087 chaperone binding IBA --
genes like me logo Genes that share ontologies with DNLZ: view
genes like me logo Genes that share phenotypes with DNLZ: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNLZ Gene

Localization for DNLZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNLZ Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNLZ gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (4)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNLZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA,IBA --
genes like me logo Genes that share ontologies with DNLZ: view

Pathways & Interactions for DNLZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNLZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0030150 protein import into mitochondrial matrix IBA --
GO:0050821 protein stabilization IBA --
genes like me logo Genes that share ontologies with DNLZ: view

No data available for Pathways by source and SIGNOR curated interactions for DNLZ Gene

Drugs & Compounds for DNLZ Gene

No Compound Related Data Available

Transcripts for DNLZ Gene

mRNA/cDNA for DNLZ Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNLZ Gene

DNL-type zinc finger:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNLZ Gene

No ASD Table

Relevant External Links for DNLZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNLZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNLZ Gene

Protein differential expression in normal tissues from HIPED for DNLZ Gene

This gene is overexpressed in Heart (14.1), Peripheral blood mononuclear cells (12.5), Bone marrow stromal cell (10.8), and CD8 Tcells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DNLZ Gene

Protein tissue co-expression partners for DNLZ Gene

NURSA nuclear receptor signaling pathways regulating expression of DNLZ Gene:


SOURCE GeneReport for Unigene cluster for DNLZ Gene:


Evidence on tissue expression from TISSUES for DNLZ Gene

  • Liver(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with DNLZ: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNLZ Gene

Orthologs for DNLZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNLZ Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNLZ 34 33
  • 98.88 (n)
(Bos Taurus)
Mammalia DNLZ 34 33
  • 81.85 (n)
(Canis familiaris)
Mammalia DNLZ 34 33
  • 81.85 (n)
(Mus musculus)
Mammalia Dnlz 16 34 33
  • 80.28 (n)
(Rattus norvegicus)
Mammalia Dnlz 33
  • 77.07 (n)
(Ornithorhynchus anatinus)
Mammalia DNLZ 34
  • 59 (a)
(Monodelphis domestica)
Mammalia DNLZ 34
  • 36 (a)
(Gallus gallus)
Aves DNLZ 34 33
  • 69.94 (n)
(Anolis carolinensis)
Reptilia DNLZ 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnlz 33
  • 57.68 (n)
(Danio rerio)
Actinopterygii dnlz 34
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12379 34
  • 36 (a)
CG8206 34
  • 21 (a)
(Caenorhabditis elegans)
Secernentea F53A3.7 34
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZIM17 36 34
  • 25 (a)
Species where no ortholog for DNLZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNLZ Gene

Gene Tree for DNLZ (if available)
Gene Tree for DNLZ (if available)
Evolutionary constrained regions (ECRs) for DNLZ: view image

Paralogs for DNLZ Gene

No data available for Paralogs for DNLZ Gene

Variants for DNLZ Gene

Sequence variations from dbSNP and Humsavar for DNLZ Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1135314 benign, Familial Candidiasis, Recessive 136,364,010(-) A/G upstream_transcript_variant
rs138344913 likely-benign, Familial Candidiasis, Recessive 136,365,192(-) C/A/T upstream_transcript_variant
rs151057624 benign, Candidiasis, familial, 2 136,364,317(-) G/A upstream_transcript_variant
rs373574599 uncertain-significance, Familial Candidiasis, Recessive 136,364,058(-) A/C upstream_transcript_variant
rs373635926 uncertain-significance, Familial Candidiasis, Recessive 136,365,182(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DNLZ Gene

Variant ID Type Subtype PubMed ID
nsv951202 CNV deletion 24416366
nsv825173 CNV gain 20364138
nsv6764 CNV deletion 18451855
nsv615962 CNV loss 21841781
nsv509333 CNV insertion 20534489
nsv469918 CNV loss 18288195
nsv1046074 CNV gain 25217958
esv2759720 CNV loss 17122850

Variation tolerance for DNLZ Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNLZ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNLZ Gene

Disorders for DNLZ Gene

MalaCards: The human disease database

(2) MalaCards diseases for DNLZ Gene - From: GeneCards

Disorder Aliases PubMed IDs
candidiasis, familial, 2
  • candf2
familial candidiasis
  • candidiasis, familial, 2
- elite association - COSMIC cancer census association via MalaCards
Search DNLZ in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DNLZ

genes like me logo Genes that share disorders with DNLZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNLZ Gene

Publications for DNLZ Gene

  1. Structural and stability studies of the human mtHsp70-escort protein 1: an essential mortalin co-chaperone. (PMID: 23462535) Dores-Silva PR … Borges JC (International journal of biological macromolecules 2013) 3 4 58
  2. The DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9. (PMID: 22162012) Vu MT … Silberg JJ (Protein science : a publication of the Protein Society 2012) 2 3 58
  3. A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity. (PMID: 21530495) Zhai P … Silberg JJ (Biochemical and biophysical research communications 2011) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for DNLZ Gene

Sources for DNLZ Gene

Loading form....