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Aliases for DNHD1 Gene

Aliases for DNHD1 Gene

  • Dynein Heavy Chain Domain 1 2 3 5
  • Dynein Heavy Chain Domain 1-Like Protein 3 4
  • Coiled-Coil Domain Containing 35 2 3
  • C11orf47 3 4
  • CCDC35 3 4
  • DNHD1L 3 4
  • DHCD1 3 4
  • Dynein Heavy Chain Domain-Containing Protein 1 3
  • Chromosome 11 Open Reading Frame 47 2
  • Dynein Heavy Chain Domain 1-Like 2
  • DNHD1 Variant Protein 3
  • Protein CCDC35 4

External Ids for DNHD1 Gene

Previous HGNC Symbols for DNHD1 Gene

  • DHCD1
  • C11orf47
  • DNHD1L
  • CCDC35

Previous GeneCards Identifiers for DNHD1 Gene

  • GC11P006178

Summaries for DNHD1 Gene

GeneCards Summary for DNHD1 Gene

DNHD1 (Dynein Heavy Chain Domain 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include microtubule motor activity. An important paralog of this gene is DNAH10.

Additional gene information for DNHD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNHD1 Gene

Genomics for DNHD1 Gene

GeneHancer (GH) Regulatory Elements for DNHD1 Gene

Promoters and enhancers for DNHD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006497 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 650.7 +0.0 41 0.6 DNHD1 TIMM10B ENSG00000283977 PIR42127
GH11J006495 Promoter 0.6 EPDnew 650.7 -1.3 -1317 0.1 SUPT5H DNHD1 LOC644169 ENSG00000283977
GH11J006498 Enhancer 0.2 ENCODE 650.7 +1.1 1096 0.2 DNHD1 TIMM10B ENSG00000283977 PIR42127
GH11J006601 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 25.5 +110.2 110236 12.4 MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 SSRP1 ZNF610 RRP8 ILK TAF10 DNHD1 FAM160A2 ENSG00000254641 DCHS1 CAVIN3 ENSG00000254400 ENSG00000285338
GH11J006680 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.3 +185.3 185290 3.4 PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 MRPL17 FAM160A2 RRP8 DNHD1 ILK GC11P006674
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNHD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNHD1 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • GR-alpha
  • GR
  • ATF
  • Hlf
  • AREB6
  • TGIF
  • Pax-2
  • Pax-6

Genomic Locations for DNHD1 Gene

Genomic Locations for DNHD1 Gene
chr11:6,497,260-6,593,758
(GRCh38/hg38)
Size:
96,499 bases
Orientation:
Plus strand
chr11:6,518,490-6,614,988
(GRCh37/hg19)
Size:
96,499 bases
Orientation:
Plus strand

Genomic View for DNHD1 Gene

Genes around DNHD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNHD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNHD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNHD1 Gene

Proteins for DNHD1 Gene

  • Protein details for DNHD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M86-DNHD1_HUMAN
    Recommended name:
    Dynein heavy chain domain-containing protein 1
    Protein Accession:
    Q96M86
    Secondary Accessions:
    • Q2NKK8
    • Q6UWI9
    • Q8NAA2
    • Q8TEE6
    • Q9NSZ9

    Protein attributes for DNHD1 Gene

    Size:
    4753 amino acids
    Molecular mass:
    533644 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ89130.1; Type=Frameshift; Positions=637; Evidence={ECO:0000305}; Sequence=BAB85004.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAB70845.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=EAW68692.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DNHD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNHD1 Gene

Post-translational modifications for DNHD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DNHD1 Gene

Domains & Families for DNHD1 Gene

Gene Families for DNHD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DNHD1 Gene

Suggested Antigen Peptide Sequences for DNHD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96M86

UniProtKB/Swiss-Prot:

DNHD1_HUMAN :
  • Belongs to the dynein heavy chain family.
Family:
  • Belongs to the dynein heavy chain family.
genes like me logo Genes that share domains with DNHD1: view

Function for DNHD1 Gene

Phenotypes From GWAS Catalog for DNHD1 Gene

Gene Ontology (GO) - Molecular Function for DNHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA --
GO:0005524 ATP binding IEA --
GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed IBA --
GO:0045503 dynein light chain binding IBA --
GO:0045505 dynein intermediate chain binding IBA --
genes like me logo Genes that share ontologies with DNHD1: view
genes like me logo Genes that share phenotypes with DNHD1: view

Animal Model Products

miRNA for DNHD1 Gene

miRTarBase miRNAs that target DNHD1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNHD1 Gene

Localization for DNHD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNHD1 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030286 dynein complex IEA,IBA --
GO:0036156 inner dynein arm IBA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with DNHD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DNHD1 Gene

Pathways & Interactions for DNHD1 Gene

SuperPathways for DNHD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003341 cilium movement IBA --
GO:0007018 microtubule-based movement IEA,IBA --
GO:0036159 inner dynein arm assembly IBA --
genes like me logo Genes that share ontologies with DNHD1: view

No data available for Pathways by source and SIGNOR curated interactions for DNHD1 Gene

Drugs & Compounds for DNHD1 Gene

No Compound Related Data Available

Transcripts for DNHD1 Gene

mRNA/cDNA for DNHD1 Gene

Unigene Clusters for DNHD1 Gene

Dynein heavy chain domain 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNHD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: -
SP2:
SP3: - - -
SP4:
SP5:
SP6: -

Relevant External Links for DNHD1 Gene

GeneLoc Exon Structure for
DNHD1
ECgene alternative splicing isoforms for
DNHD1

Expression for DNHD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNHD1 Gene

mRNA differential expression in normal tissues according to GTEx for DNHD1 Gene

This gene is overexpressed in Testis (x6.3).

Protein differential expression in normal tissues from HIPED for DNHD1 Gene

This gene is overexpressed in Prostate (59.8) and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DNHD1 Gene



Protein tissue co-expression partners for DNHD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DNHD1 Gene:

DNHD1

SOURCE GeneReport for Unigene cluster for DNHD1 Gene:

Hs.720080

Evidence on tissue expression from TISSUES for DNHD1 Gene

  • Intestine(4.1)
  • Spleen(4.1)
  • Liver(3.8)
genes like me logo Genes that share expression patterns with DNHD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNHD1 Gene

Orthologs for DNHD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DNHD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNHD1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNHD1 34 33
  • 83.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DNHD1 34 33
  • 81.44 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dnhd1 16 34 33
  • 77.63 (n)
rat
(Rattus norvegicus)
Mammalia Dnhd1-ps1 33
  • 77.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 47 (a)
OneToMany
-- 34
  • 45 (a)
OneToMany
-- 34
  • 40 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia DNHD1 34
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
OneToMany
-- 34
  • 35 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dnhd1 33
  • 46.44 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101882863 33
  • 43.08 (n)
DNHD1 34
  • 24 (a)
OneToOne
Species where no ortholog for DNHD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNHD1 Gene

ENSEMBL:
Gene Tree for DNHD1 (if available)
TreeFam:
Gene Tree for DNHD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DNHD1: view image

Paralogs for DNHD1 Gene

Paralogs for DNHD1 Gene

(2) SIMAP similar genes for DNHD1 Gene using alignment to 6 proteins:

  • DNHD1_HUMAN
  • D3DQT9_HUMAN
  • E9PJT4_HUMAN
  • E9PM64_HUMAN
  • J3KTE2_HUMAN
  • J3QRE5_HUMAN
genes like me logo Genes that share paralogs with DNHD1: view

Variants for DNHD1 Gene

Sequence variations from dbSNP and Humsavar for DNHD1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000009798 -- 6,545,416(+) C/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000045798 -- 6,553,716(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000101238 -- 6,517,164(+) T/A intron_variant
rs1000103635 -- 6,548,011(+) C/G coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000113842 -- 6,505,253(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DNHD1 Gene

Variant ID Type Subtype PubMed ID
esv25728 CNV loss 19812545
esv2661307 CNV deletion 23128226
esv3547265 CNV deletion 23714750
nsv515990 CNV loss 19592680
nsv553372 CNV loss 21841781
nsv972944 CNV duplication 23825009

Variation tolerance for DNHD1 Gene

Gene Damage Index Score: 26.79; 99.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNHD1 Gene

Human Gene Mutation Database (HGMD)
DNHD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNHD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNHD1 Gene

Disorders for DNHD1 Gene

Additional Disease Information for DNHD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DNHD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNHD1 Gene

Publications for DNHD1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2003) 3 4 58

Products for DNHD1 Gene

Sources for DNHD1 Gene

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