Aliases for DNER Gene

Aliases for DNER Gene

  • Delta/Notch Like EGF Repeat Containing 2 3 5
  • Delta And Notch-Like Epidermal Growth Factor-Related Receptor 3 4
  • UNQ26 2 3
  • Bet 2 3
  • Delta-Notch-Like EGF Repeat-Containing Transmembrane 3
  • Delta/Notch-Like EGF Repeat Containing 2
  • WUGSC:H_NH0150O02.1 3
  • H_NH0150O02.1 3
  • DNER 5
  • BET 4

External Ids for DNER Gene

Previous GeneCards Identifiers for DNER Gene

  • GC02M228282
  • GC02M228954
  • GC02M230186
  • GC02M230424
  • GC02M230047
  • GC02M229930
  • GC02M222063

Summaries for DNER Gene

GeneCards Summary for DNER Gene

DNER (Delta/Notch Like EGF Repeat Containing) is a Protein Coding gene. Diseases associated with DNER include Impulse Control Disorder and Kleptomania. Among its related pathways are Signaling by GPCR and Notch Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include calcium ion binding and clathrin binding. An important paralog of this gene is NOTCH4.

UniProtKB/Swiss-Prot Summary for DNER Gene

  • Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).

Gene Wiki entry for DNER Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DNER Gene

Genomics for DNER Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DNER Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J229712 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 600.7 +0.2 154 2.8 CTCF TEAD4 PRDM10 REST ZNF692 PRDM1 ZIC2 POLR2A RXRB PATZ1 DNER HSALNG0022829 TRIP12 ENSG00000235419 FBXO36 ENSG00000235993 lnc-FBXO36-1 PID1
GH02J229406 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 8.4 +306.0 305997 5.1 CEBPG CREB1 GATAD2A ARID3A TARDBP JUND FOXA1 PRDM1 REST CEBPA ENSG00000287791 LOC107985994 PID1 DNER
GH02J230711 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 4.6 -999.3 -999258 5.3 SP1 GATAD2A CTCF PRDM10 ZNF629 TFE3 LEF1 IKZF1 POLR2A BACH1 CAB39 lnc-GPR55-4 RNU6-268P TRIP12 NCL PSMD1 DNER lnc-CAB39-1 BANF1P3 ITM2C
GH02J229443 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 6.6 +269.4 269354 3.6 GATAD2A TFE3 NFKBIZ POLR2A CEBPA SOX13 CEBPB SP1 JUND CTCF PID1 DNER TRIP12 lnc-PID1-3 LOC107985994
GH02J229411 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 7.4 +298.8 298754 6.4 ATF7 POLR2A ZNF10 CREB1 ATF2 SPI1 SMARCA4 JUND NANOG JUN PID1 DNER LOC107985994 lnc-PID1-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNER on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DNER

Top Transcription factor binding sites by QIAGEN in the DNER gene promoter:
  • AP-1
  • AP-4
  • ATF
  • ATF-2
  • c-Jun
  • MyoD
  • NRSF form 1
  • NRSF form 2

Genomic Locations for DNER Gene

Genomic Locations for DNER Gene
chr2:229,357,629-229,714,555
(GRCh38/hg38)
Size:
356,927 bases
Orientation:
Minus strand
chr2:230,222,345-230,579,286
(GRCh37/hg19)
Size:
356,942 bases
Orientation:
Minus strand

Genomic View for DNER Gene

Genes around DNER on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNER Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNER Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNER Gene

Proteins for DNER Gene

  • Protein details for DNER Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFT8-DNER_HUMAN
    Recommended name:
    Delta and Notch-like epidermal growth factor-related receptor
    Protein Accession:
    Q8NFT8
    Secondary Accessions:
    • A6NP39
    • Q53R88
    • Q53TP7
    • Q53TQ5
    • Q8IYT0
    • Q8TB42
    • Q9NTF1
    • Q9UDM2

    Protein attributes for DNER Gene

    Size:
    737 amino acids
    Molecular mass:
    78475 Da
    Quaternary structure:
    • Interacts with AP1G1. Interacts with NOTCH1 (By similarity).

neXtProt entry for DNER Gene

Post-translational modifications for DNER Gene

  • Glycosylation at Ser169, Thr172, Thr174, Thr177, Asn223, and Asn564
  • Modification sites at PhosphoSitePlus

Other Protein References for DNER Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNER Gene

Domains & Families for DNER Gene

Gene Families for DNER Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins

Protein Domains for DNER Gene

InterPro:
Blocks:
  • Aspartic acid and asparagine hydroxylation site
  • EGF-like calcium-binding
ProtoNet:

Suggested Antigen Peptide Sequences for DNER Gene

GenScript: Design optimal peptide antigens:
  • Delta and Notch-like epidermal growth factor-related receptor (DNER_HUMAN)
genes like me logo Genes that share domains with DNER: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DNER Gene

Function for DNER Gene

Molecular function for DNER Gene

UniProtKB/Swiss-Prot Function:
Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).

Phenotypes From GWAS Catalog for DNER Gene

Gene Ontology (GO) - Molecular Function for DNER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 11950833
GO:0005112 Notch binding IEA,IBA 21873635
GO:0005509 calcium ion binding NAS 11950833
GO:0005515 protein binding IPI 11950833
GO:0030276 clathrin binding TAS 11950833
genes like me logo Genes that share ontologies with DNER: view
genes like me logo Genes that share phenotypes with DNER: view

Animal Models for DNER Gene

MGI Knock Outs for DNER:
  • Dner Dner<tm1Hta>
  • Dner Dner<tm3b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for DNER

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNER

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DNER Gene

Localization for DNER Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNER Gene

Cell membrane. Single-pass type I membrane protein. Note=Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNER gene
Compartment Confidence
plasma membrane 5
endosome 5
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
golgi apparatus 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for DNER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 11950833
GO:0005886 plasma membrane IEA,IDA 11950833
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IEA,IDA 11950833
genes like me logo Genes that share ontologies with DNER: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DNER Gene

Pathways & Interactions for DNER Gene

genes like me logo Genes that share pathways with DNER: view

Pathways by source for DNER Gene

SIGNOR curated interactions for DNER Gene

Activates:

Gene Ontology (GO) - Biological Process for DNER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration NAS 11950833
GO:0006897 endocytosis NAS 11950833
GO:0007219 Notch signaling pathway IEA --
GO:0007220 Notch receptor processing IEA --
GO:0007416 synapse assembly NAS 11950833
genes like me logo Genes that share ontologies with DNER: view

Drugs & Compounds for DNER Gene

No Compound Related Data Available

Transcripts for DNER Gene

mRNA/cDNA for DNER Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNER

Alternative Splicing Database (ASD) splice patterns (SP) for DNER Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: -
SP2:
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for DNER Gene

GeneLoc Exon Structure for
DNER

Expression for DNER Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNER Gene

mRNA differential expression in normal tissues according to GTEx for DNER Gene

This gene is overexpressed in Brain - Hypothalamus (x6.2), Brain - Substantia nigra (x5.6), and Brain - Spinal cord (cervical c-1) (x4.3).

Protein differential expression in normal tissues from HIPED for DNER Gene

This gene is overexpressed in Cerebrospinal fluid (27.3), Vitreous humor (18.6), and Fetal Brain (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DNER Gene



Protein tissue co-expression partners for DNER Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DNER

SOURCE GeneReport for Unigene cluster for DNER Gene:

Hs.234074

mRNA Expression by UniProt/SwissProt for DNER Gene:

Q8NFT8-DNER_HUMAN
Tissue specificity: Expressed in brain, spinal cord and adrenal gland.

Evidence on tissue expression from TISSUES for DNER Gene

  • Nervous system(5)
  • Saliva(4.2)
  • Skin(2.8)
  • Heart(2.2)
  • Blood(2.2)
  • Adrenal gland(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with DNER: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DNER Gene

Orthologs for DNER Gene

This gene was present in the common ancestor of animals.

Orthologs for DNER Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DNER 30 31
  • 99.37 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DNER 30 31
  • 89.25 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DNER 30 31
  • 87.81 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dner 30 17 31
  • 87.43 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dner 30
  • 87.2 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia DNER 31
  • 86 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DNER 30 31
  • 75.18 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DNER 31
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dner 30
  • 69.34 (n)
Str.12208 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.17677 30
Zebrafish
(Danio rerio)
Actinopterygii dner 30 31
  • 62.67 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta wry 31
  • 17 (a)
OneToMany
Species where no ortholog for DNER was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DNER Gene

ENSEMBL:
Gene Tree for DNER (if available)
TreeFam:
Gene Tree for DNER (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DNER: view image

Paralogs for DNER Gene

Paralogs for DNER Gene

genes like me logo Genes that share paralogs with DNER: view

Variants for DNER Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DNER Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
716097 Benign: not provided 229,591,740(-) G/A MISSENSE_VARIANT
716764 Benign: not provided 229,366,881(-) C/T SYNONYMOUS_VARIANT
723034 Benign: not provided 229,367,103(-) G/A SYNONYMOUS_VARIANT
727651 Benign: not provided 229,588,498(-) G/A INTRON_VARIANT
734588 Benign: not provided 229,447,500(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for DNER Gene

Structural Variations from Database of Genomic Variants (DGV) for DNER Gene

Variant ID Type Subtype PubMed ID
esv2290408 CNV deletion 18987734
esv25345 CNV loss 19812545
esv2652970 CNV deletion 19546169
esv2664843 CNV deletion 23128226
esv2669440 CNV deletion 23128226
esv2721589 CNV deletion 23290073
esv2751841 CNV gain 17911159
esv2760575 CNV loss 21179565
esv3304639 CNV mobile element insertion 20981092
esv3305035 CNV mobile element insertion 20981092
esv3308969 CNV mobile element insertion 20981092
esv3345655 CNV insertion 20981092
esv3399202 CNV insertion 20981092
esv3436124 CNV insertion 20981092
esv3561125 CNV deletion 23714750
esv3594572 CNV loss 21293372
esv3594574 CNV loss 21293372
esv3594575 CNV loss 21293372
esv3594577 CNV loss 21293372
esv3594579 CNV loss 21293372
nsv1004285 CNV gain 25217958
nsv1077381 CNV duplication 25765185
nsv1141374 CNV duplication 24896259
nsv1146993 CNV duplication 26484159
nsv3198 CNV insertion 18451855
nsv473859 CNV novel sequence insertion 20440878
nsv477801 CNV novel sequence insertion 20440878
nsv520821 CNV loss 19592680
nsv522560 CNV loss 19592680
nsv584648 CNV gain 21841781
nsv834564 CNV gain 17160897

Variation tolerance for DNER Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNER Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNER

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNER Gene

Disorders for DNER Gene

MalaCards: The human disease database

(5) MalaCards diseases for DNER Gene - From: DISEASES

Disorder Aliases PubMed IDs
impulse control disorder
  • disruptive, impulse control, and conduct disorders
kleptomania
  • pathological stealing
pyromania
  • firesetting behavior
pathological gambling
  • compulsive gambling
spinal cord lipoma
  • lipoma of spinal cord
- elite association - COSMIC cancer census association via MalaCards
Search DNER in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DNER

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with DNER: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNER Gene

Publications for DNER Gene

  1. BET, a novel neuronal transmembrane protein with multiple EGF-like motifs. (PMID: 11997712) Nishizumi H … Sakano H (Neuroreport 2002) 2 3 4
  2. Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. (PMID: 11950833) Eiraku M … Kengaku M (The Journal of biological chemistry 2002) 2 3 4
  3. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P … Loo JA (Journal of proteome research 2006) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for DNER Gene

Sources for DNER Gene