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DNER (Delta/Notch Like EGF Repeat Containing) is a Protein Coding gene. Diseases associated with DNER include Impulse Control Disorder and Kleptomania. Among its related pathways are Signaling by GPCR and Notch Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include calcium ion binding and clathrin binding. An important paralog of this gene is NOTCH4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | TAS | 11950833 |
GO:0005112 | Notch binding | IEA,IBA | 21873635 |
GO:0005509 | calcium ion binding | NAS | 11950833 |
GO:0005515 | protein binding | IPI | 11950833 |
GO:0030276 | clathrin binding | TAS | 11950833 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005769 | early endosome | IDA | 11950833 |
GO:0005886 | plasma membrane | IEA,IDA | 11950833 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0030425 | dendrite | IEA,IDA | 11950833 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Notch Signaling Pathway (WikiPathways) | ||
2 | Signaling by NOTCH1 | ||
3 | NOTCH2 Activation and Transmission of Signal to the Nucleus | ||
4 | Signaling by GPCR | ||
5 | Canonical and Non-canonical Notch signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001764 | neuron migration | NAS | 11950833 |
GO:0006897 | endocytosis | NAS | 11950833 |
GO:0007219 | Notch signaling pathway | IEA | -- |
GO:0007220 | Notch receptor processing | IEA | -- |
GO:0007416 | synapse assembly | NAS | 11950833 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DNER 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DNER 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DNER 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dner 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dner 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | DNER 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DNER 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DNER 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dner 30 |
|
||
Str.12208 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.17677 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dner 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | wry 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
716097 | Benign: not provided | 229,591,740(-) | G/A | MISSENSE_VARIANT | |
716764 | Benign: not provided | 229,366,881(-) | C/T | SYNONYMOUS_VARIANT | |
723034 | Benign: not provided | 229,367,103(-) | G/A | SYNONYMOUS_VARIANT | |
727651 | Benign: not provided | 229,588,498(-) | G/A | INTRON_VARIANT | |
734588 | Benign: not provided | 229,447,500(-) | G/A | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
impulse control disorder |
|
|
kleptomania |
|
|
pyromania |
|
|
pathological gambling |
|
|
spinal cord lipoma |
|
|