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Aliases for DNER Gene

Aliases for DNER Gene

  • Delta/Notch Like EGF Repeat Containing 2 3 5
  • Delta And Notch-Like Epidermal Growth Factor-Related Receptor 3
  • Delta-Notch-Like EGF Repeat-Containing Transmembrane 3
  • Delta/Notch-Like EGF Repeat Containing 2
  • WUGSC:H_NH0150O02.1 3
  • H_NH0150O02.1 3
  • UNQ26 3
  • Bet 3
  • BET 4

External Ids for DNER Gene

Previous GeneCards Identifiers for DNER Gene

  • GC02M228282
  • GC02M228954
  • GC02M230186
  • GC02M230424
  • GC02M230047
  • GC02M229930
  • GC02M222063

Summaries for DNER Gene

GeneCards Summary for DNER Gene

DNER (Delta/Notch Like EGF Repeat Containing) is a Protein Coding gene. Among its related pathways are Canonical and Non-canonical Notch signaling and Signaling by NOTCH1. Gene Ontology (GO) annotations related to this gene include calcium ion binding and clathrin binding. An important paralog of this gene is CRB1.

UniProtKB/Swiss-Prot for DNER Gene

  • Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).

Gene Wiki entry for DNER Gene

Additional gene information for DNER Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNER Gene

Genomics for DNER Gene

GeneHancer (GH) Regulatory Elements for DNER Gene

Promoters and enhancers for DNER Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J229715 Promoter 1.3 EPDnew Ensembl 650.7 +0.1 69 0.2 ZNF335 MXI1 GLIS2 RFX1 POLR2A VEZF1 DNER FBXO36 ENSG00000235993
GH02J229714 Enhancer 0.8 ENCODE 650.7 -0.5 -456 0.6 ELF3 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZSCAN9 RARA ZNF335 GLIS2 DNER TRIP12 LOC101928816 FBXO36 PIR44053
GH02J229716 Enhancer 0.7 ENCODE 650.7 -0.9 -910 0.2 ZNF792 SAP130 DMAP1 KMT2B KDM3A ZSCAN9 ZNF335 IKZF5 THAP11 ZBTB20 DNER FBXO36 PIR44053
GH02J229406 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.4 +306.0 305990 5.1 PKNOX1 FOXA2 NEUROD1 SIN3A FOS DEK SP3 REST ZNF592 STAT3 PID1 TRIP12 DNER RNU7-9P
GH02J229443 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.6 +269.2 269219 2.8 ELF3 FOXA2 SIN3A DMAP1 RAD21 ZNF48 FOS NFKBIZ CEBPB MIER2 PID1 DNER TRIP12 RNU7-9P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNER on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNER gene promoter:
  • c-Jun
  • ATF-2
  • NRSF form 2
  • NRSF form 1
  • AP-1
  • ATF
  • MyoD
  • AP-4

Genomic Locations for DNER Gene

Genomic Locations for DNER Gene
356,942 bases
Minus strand
356,942 bases
Minus strand

Genomic View for DNER Gene

Genes around DNER on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNER Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNER Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNER Gene

Proteins for DNER Gene

  • Protein details for DNER Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Delta and Notch-like epidermal growth factor-related receptor
    Protein Accession:
    Secondary Accessions:
    • A6NP39
    • Q53R88
    • Q53TP7
    • Q53TQ5
    • Q8IYT0
    • Q8TB42
    • Q9NTF1
    • Q9UDM2

    Protein attributes for DNER Gene

    737 amino acids
    Molecular mass:
    78475 Da
    Quaternary structure:
    • Interacts with AP1G1. Interacts with NOTCH1 (By similarity).

neXtProt entry for DNER Gene

Post-translational modifications for DNER Gene

  • Glycosylation at Asn564, Asn223, and Thr177
  • Modification sites at PhosphoSitePlus

Other Protein References for DNER Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNER Gene

Domains & Families for DNER Gene

Gene Families for DNER Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for DNER Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNER: view

No data available for UniProtKB/Swiss-Prot for DNER Gene

Function for DNER Gene

Molecular function for DNER Gene

UniProtKB/Swiss-Prot Function:
Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).

Phenotypes From GWAS Catalog for DNER Gene

Gene Ontology (GO) - Molecular Function for DNER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 11950833
GO:0005112 Notch binding IEA --
GO:0005509 calcium ion binding NAS 11950833
GO:0005515 protein binding IPI 11950833
GO:0030276 clathrin binding TAS 11950833
genes like me logo Genes that share ontologies with DNER: view
genes like me logo Genes that share phenotypes with DNER: view

Animal Models for DNER Gene

MGI Knock Outs for DNER:

Animal Model Products

  • Taconic Biosciences Mouse Models for DNER

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DNER Gene

Localization for DNER Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNER Gene

Cell membrane; Single-pass type I membrane protein. Note=Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNER gene
Compartment Confidence
plasma membrane 5
endosome 5
extracellular 3
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DNER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 11950833
GO:0005886 plasma membrane IEA,IDA 11950833
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IDA,IEA 11950833
genes like me logo Genes that share ontologies with DNER: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DNER Gene

Pathways & Interactions for DNER Gene

genes like me logo Genes that share pathways with DNER: view

Pathways by source for DNER Gene

SIGNOR curated interactions for DNER Gene


Gene Ontology (GO) - Biological Process for DNER Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration NAS 11950833
GO:0006897 endocytosis NAS 11950833
GO:0007219 Notch signaling pathway IEA --
GO:0007220 Notch receptor processing IEA --
GO:0007416 synapse assembly NAS 11950833
genes like me logo Genes that share ontologies with DNER: view

Drugs & Compounds for DNER Gene

No Compound Related Data Available

Transcripts for DNER Gene

mRNA/cDNA for DNER Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(133) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNER Gene

Delta/notch-like EGF repeat containing:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNER Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: -
SP3: - -
SP4: -

Relevant External Links for DNER Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNER Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNER Gene

mRNA differential expression in normal tissues according to GTEx for DNER Gene

This gene is overexpressed in Brain - Hypothalamus (x6.2), Brain - Substantia nigra (x5.6), and Brain - Spinal cord (cervical c-1) (x4.3).

Protein differential expression in normal tissues from HIPED for DNER Gene

This gene is overexpressed in Cerebrospinal fluid (27.3), Vitreous humor (18.6), and Fetal Brain (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DNER Gene

Protein tissue co-expression partners for DNER Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNER Gene:


SOURCE GeneReport for Unigene cluster for DNER Gene:


mRNA Expression by UniProt/SwissProt for DNER Gene:

Tissue specificity: Expressed in brain, spinal cord and adrenal gland.

Evidence on tissue expression from TISSUES for DNER Gene

  • Nervous system(4.9)
  • Saliva(4)
genes like me logo Genes that share expression patterns with DNER: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DNER Gene

Orthologs for DNER Gene

This gene was present in the common ancestor of animals.

Orthologs for DNER Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNER 34 33
  • 99.37 (n)
(Canis familiaris)
Mammalia DNER 34 33
  • 89.25 (n)
(Bos Taurus)
Mammalia DNER 34 33
  • 87.81 (n)
(Mus musculus)
Mammalia Dner 16 34 33
  • 87.43 (n)
(Rattus norvegicus)
Mammalia Dner 33
  • 87.2 (n)
(Ornithorhynchus anatinus)
Mammalia DNER 34
  • 86 (a)
(Gallus gallus)
Aves DNER 34 33
  • 75.18 (n)
(Anolis carolinensis)
Reptilia DNER 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dner 33
  • 69.34 (n)
Str.12208 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.17677 33
(Danio rerio)
Actinopterygii dner 34 33
  • 62.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta wry 34
  • 17 (a)
Species where no ortholog for DNER was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNER Gene

Gene Tree for DNER (if available)
Gene Tree for DNER (if available)
Evolutionary constrained regions (ECRs) for DNER: view image

Paralogs for DNER Gene

Paralogs for DNER Gene

genes like me logo Genes that share paralogs with DNER: view

Variants for DNER Gene

Sequence variations from dbSNP and Humsavar for DNER Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000005960 -- 229,658,124(-) G/C intron_variant
rs1000006417 -- 229,571,835(-) G/A intron_variant
rs1000013516 -- 229,625,929(-) T/G intron_variant
rs1000020219 -- 229,466,880(-) T/C intron_variant
rs1000020461 -- 229,385,520(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DNER Gene

Variant ID Type Subtype PubMed ID
esv2290408 CNV deletion 18987734
esv25345 CNV loss 19812545
esv2652970 CNV deletion 19546169
esv2664843 CNV deletion 23128226
esv2669440 CNV deletion 23128226
esv2721589 CNV deletion 23290073
esv2751841 CNV gain 17911159
esv2760575 CNV loss 21179565
esv3304639 CNV mobile element insertion 20981092
esv3305035 CNV mobile element insertion 20981092
esv3308969 CNV mobile element insertion 20981092
esv3345655 CNV insertion 20981092
esv3399202 CNV insertion 20981092
esv3436124 CNV insertion 20981092
esv3561125 CNV deletion 23714750
esv3594572 CNV loss 21293372
esv3594574 CNV loss 21293372
esv3594575 CNV loss 21293372
esv3594577 CNV loss 21293372
esv3594579 CNV loss 21293372
nsv1004285 CNV gain 25217958
nsv1077381 CNV duplication 25765185
nsv1141374 CNV duplication 24896259
nsv1146993 CNV duplication 26484159
nsv3198 CNV insertion 18451855
nsv473859 CNV novel sequence insertion 20440878
nsv477801 CNV novel sequence insertion 20440878
nsv520821 CNV loss 19592680
nsv522560 CNV loss 19592680
nsv584648 CNV gain 21841781
nsv834564 CNV gain 17160897

Variation tolerance for DNER Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNER Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNER Gene

Disorders for DNER Gene

Additional Disease Information for DNER

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DNER Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNER Gene

Publications for DNER Gene

  1. BET, a novel neuronal transmembrane protein with multiple EGF-like motifs. (PMID: 11997712) Nishizumi H … Sakano H (Neuroreport 2002) 2 3 4 58
  2. Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. (PMID: 11950833) Eiraku M … Kengaku M (The Journal of biological chemistry 2002) 2 3 4 58
  3. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P … Loo JA (Journal of proteome research 2006) 3 4 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DNER Gene

Sources for DNER Gene

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