Aliases for DNASE2 Gene
External Ids for DNASE2 Gene
Previous HGNC Symbols for DNASE2 Gene
Previous GeneCards Identifiers for DNASE2 Gene
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]
GeneCards Summary for DNASE2 Gene
DNASE2 (Deoxyribonuclease 2, Lysosomal) is a Protein Coding gene. Diseases associated with DNASE2 include Calcific Tendinitis and Aicardi-Goutieres Syndrome. Among its related pathways are Lysosome and Clathrin derived vesicle budding. Gene Ontology (GO) annotations related to this gene include endodeoxyribonuclease activity and deoxyribonuclease II activity. An important paralog of this gene is DNASE2B.
UniProtKB/Swiss-Prot Summary for DNASE2 Gene
Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.