Aliases for DNAL1 Gene
External Ids for DNAL1 Gene
Previous HGNC Symbols for DNAL1 Gene
Previous GeneCards Identifiers for DNAL1 Gene
This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]
GeneCards Summary for DNAL1 Gene
DNAL1 (Dynein Axonemal Light Chain 1) is a Protein Coding gene. Diseases associated with DNAL1 include Ciliary Dyskinesia, Primary, 16 and Primary Ciliary Dyskinesia. Among its related pathways are Parkinson disease.
UniProtKB/Swiss-Prot Summary for DNAL1 Gene
Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (PubMed:21496787).