Aliases for DNAJC9 Gene

Aliases for DNAJC9 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C9 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 9 2 3
  • DnaJ Homolog Subfamily C Member 9 3 4
  • DnaJ Protein SB73 3 4
  • HDJC9 3 4
  • JDD1 3
  • SB73 3

External Ids for DNAJC9 Gene

Previous GeneCards Identifiers for DNAJC9 Gene

  • GC10P073706
  • GC10P074031
  • GC10M074836
  • GC10M074348
  • GC10M074350
  • GC10M074673
  • GC10M074676
  • GC10M074943
  • GC10M068996

Summaries for DNAJC9 Gene

GeneCards Summary for DNAJC9 Gene

DNAJC9 (DnaJ Heat Shock Protein Family (Hsp40) Member C9) is a Protein Coding gene. Diseases associated with DNAJC9 include Recurrent Corneal Erosion and Corneal Degeneration. An important paralog of this gene is DNAJC13.

UniProtKB/Swiss-Prot Summary for DNAJC9 Gene

  • May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8.

Additional gene information for DNAJC9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DNAJC9 Gene

Genomics for DNAJC9 Gene

GeneHancer (GH) Regulatory Elements for DNAJC9 Gene

Promoters and enhancers for DNAJC9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJC9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJC9 gene promoter:
  • AhR
  • AML1a
  • AREB6
  • Arnt
  • CUTL1
  • Nkx2-5
  • NRF-2
  • Pbx1a
  • STAT5A

Genomic Locations for DNAJC9 Gene

Genomic Locations for DNAJC9 Gene
chr10:73,183,362-73,248,862
(GRCh38/hg38)
Size:
65,501 bases
Orientation:
Minus strand
chr10:74,943,120-75,008,620
(GRCh37/hg19)
Size:
65,501 bases
Orientation:
Minus strand

Genomic View for DNAJC9 Gene

Genes around DNAJC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC9 Gene

Proteins for DNAJC9 Gene

  • Protein details for DNAJC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXX5-DNJC9_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 9
    Protein Accession:
    Q8WXX5
    Secondary Accessions:
    • B2RMW6

    Protein attributes for DNAJC9 Gene

    Size:
    260 amino acids
    Molecular mass:
    29910 Da
    Quaternary structure:
    • Interacts (via J domain) with HSPA1A, HSPA1B and HSPA8.

neXtProt entry for DNAJC9 Gene

Post-translational modifications for DNAJC9 Gene

  • Ubiquitination at Lys107 and Lys217
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC9 Gene

Domains & Families for DNAJC9 Gene

Gene Families for DNAJC9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DNAJC9 Gene

Suggested Antigen Peptide Sequences for DNAJC9 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ36843 fis, clone ASTRO2012552, highly similar to DnaJ homolog subfamily C member 9 (B2RMW6_HUMAN)
  • DnaJ protein SB73 (DNJC9_HUMAN)
genes like me logo Genes that share domains with DNAJC9: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DNAJC9 Gene

Function for DNAJC9 Gene

Molecular function for DNAJC9 Gene

UniProtKB/Swiss-Prot Function:
May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8.
UniProtKB/Swiss-Prot Induction:
By heat shock, bacterial lipopolysaccharides (LPS), phorbol 12-myristate 13-acetate (PMA), and the cytokine TNF (at protein level).

Phenotypes From GWAS Catalog for DNAJC9 Gene

Gene Ontology (GO) - Molecular Function for DNAJC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19410544
GO:0031072 heat shock protein binding IPI,IBA 17182002
genes like me logo Genes that share ontologies with DNAJC9: view
genes like me logo Genes that share phenotypes with DNAJC9: view

Animal Models for DNAJC9 Gene

MGI Knock Outs for DNAJC9:
  • Dnajc9 Dnajc9<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJC9 Gene

Localization for DNAJC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC9 Gene

Nucleus. Cytoplasm. Cell membrane. Note=Predominantly nuclear. Translocates to the cytoplasm and membrane after heat shock. {ECO:0000269 PubMed:17182002}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC9 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNAJC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 17182002
GO:0005634 nucleus IDA,IBA 17182002
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IBA 17182002
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with DNAJC9: view

Pathways & Interactions for DNAJC9 Gene

PathCards logo

SuperPathways for DNAJC9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032781 positive regulation of ATPase activity IDA 17182002
genes like me logo Genes that share ontologies with DNAJC9: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC9 Gene

Drugs & Compounds for DNAJC9 Gene

No Compound Related Data Available

Transcripts for DNAJC9 Gene

mRNA/cDNA for DNAJC9 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC9 Gene

No ASD Table

Relevant External Links for DNAJC9 Gene

GeneLoc Exon Structure for
DNAJC9
ECgene alternative splicing isoforms for
DNAJC9

Expression for DNAJC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC9 Gene

Protein differential expression in normal tissues from HIPED for DNAJC9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DNAJC9 Gene



Protein tissue co-expression partners for DNAJC9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC9 Gene:

DNAJC9

SOURCE GeneReport for Unigene cluster for DNAJC9 Gene:

Hs.732485

mRNA Expression by UniProt/SwissProt for DNAJC9 Gene:

Q8WXX5-DNJC9_HUMAN
Tissue specificity: Expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, thymus, ovary, colon and peripheral blood.

Evidence on tissue expression from TISSUES for DNAJC9 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Blood(2.4)
genes like me logo Genes that share expression patterns with DNAJC9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC9 Gene

Orthologs for DNAJC9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC9 33
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJC9 33 32
  • 90.93 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC9 33 32
  • 89.56 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc9 17 33 32
  • 86.83 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc9 32
  • 86.28 (n)
oppossum
(Monodelphis domestica)
Mammalia DNAJC9 33
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC9 33
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJC9 33 32
  • 71.49 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC9 33
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc9 32
  • 67.22 (n)
MGC76175 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.24030 32
zebrafish
(Danio rerio)
Actinopterygii dnajc9 33 32
  • 61.11 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3259 32
fruit fly
(Drosophila melanogaster)
Insecta CG6693 33 32
  • 52.42 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004849 32
  • 51.36 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-23 33 32
  • 47.66 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G12170 32
  • 48.86 (n)
rice
(Oryza sativa)
Liliopsida Os02g0195800 32
  • 45.22 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1071.09c 32
  • 49.47 (n)
Species where no ortholog for DNAJC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC9 Gene

ENSEMBL:
Gene Tree for DNAJC9 (if available)
TreeFam:
Gene Tree for DNAJC9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DNAJC9: view image

Paralogs for DNAJC9 Gene

Pseudogenes.org Pseudogenes for DNAJC9 Gene

genes like me logo Genes that share paralogs with DNAJC9: view

Variants for DNAJC9 Gene

Sequence variations from dbSNP and Humsavar for DNAJC9 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs886047186 uncertain-significance, Combined oxidative phosphorylation deficiency 73,248,992(-) C/A upstream_transcript_variant
rs886047187 uncertain-significance, Combined oxidative phosphorylation deficiency 73,249,091(-) T/C upstream_transcript_variant
rs1000131840 -- 73,248,891(-) A/G upstream_transcript_variant
rs1000168196 -- 73,244,053(-) C/T intron_variant
rs1000231874 -- 73,248,522(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC9 Gene

Variant ID Type Subtype PubMed ID
nsv948066 CNV duplication 23825009

Variation tolerance for DNAJC9 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJC9 Gene

Human Gene Mutation Database (HGMD)
DNAJC9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC9 Gene

Disorders for DNAJC9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DNAJC9 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
recurrent corneal erosion
  • recurrent erosion of cornea
corneal degeneration
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DNAJC9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DNAJC9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJC9 Gene

Publications for DNAJC9 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  2. HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain. (PMID: 17182002) Han C … Cao X (Biochemical and biophysical research communications 2007) 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. ATG5 is required for B cell polarization and presentation of particulate antigens. (PMID: 30196744) Arbogast F … Gros F (Autophagy 2019) 3 56
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 56

Products for DNAJC9 Gene

Sources for DNAJC9 Gene