Aliases for DNAJC7 Gene
External Ids for DNAJC7 Gene
Previous HGNC Symbols for DNAJC7 Gene
Previous GeneCards Identifiers for DNAJC7 Gene
This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
GeneCards Summary for DNAJC7 Gene
DNAJC7 (DnaJ Heat Shock Protein Family (Hsp40) Member C7) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and Constitutive Androstane Receptor Pathway. Gene Ontology (GO) annotations related to this gene include heat shock protein binding. An important paralog of this gene is DNAJC3.
UniProtKB/Swiss-Prot Summary for DNAJC7 Gene
Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).