DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger... See more...

Aliases for DNAJC6 Gene

Aliases for DNAJC6 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C6 2 3 5
  • Putative Tyrosine-Protein Phosphatase Auxilin 3 4
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 6 2 3
  • Auxilin 2 3
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 6 3
  • DnaJ Homolog Subfamily C Member 6 4
  • EC 3.1.3.48 4
  • KIAA0473 4
  • PARK19 3
  • DJC6 3

External Ids for DNAJC6 Gene

Previous GeneCards Identifiers for DNAJC6 Gene

  • GC01P065681
  • GC01P064649
  • GC01P065077
  • GC01P065090
  • GC01P065145
  • GC01P065442
  • GC01P065487
  • GC01P063839
  • GC01P065714

Summaries for DNAJC6 Gene

Entrez Gene Summary for DNAJC6 Gene

  • DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DNAJC6 Gene

DNAJC6 (DnaJ Heat Shock Protein Family (Hsp40) Member C6) is a Protein Coding gene. Diseases associated with DNAJC6 include Parkinson Disease 19A, Juvenile-Onset and Atypical Juvenile Parkinsonism. Among its related pathways are Clathrin derived vesicle budding and Endocytosis. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine phosphatase activity. An important paralog of this gene is GAK.

UniProtKB/Swiss-Prot Summary for DNAJC6 Gene

  • Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity).

Gene Wiki entry for DNAJC6 Gene

Additional gene information for DNAJC6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DNAJC6 Gene

Genomics for DNAJC6 Gene

GeneHancer (GH) Regulatory Elements for DNAJC6 Gene

Promoters and enhancers for DNAJC6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J065308 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 514.5 +61.5 61453 2 HNRNPK NRF1 PHB2 ZIC2 REST ZBTB10 ZBTB11 ZNF423 AFF1 ZBTB26 DNAJC6 LOC102724416 PDE4B piR-34093-002
GH01J065264 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 512.5 +17.4 17397 2.3 ZSCAN5C MYC USF1 TEAD4 ZNF639 CTCF ZNF10 ZIC2 POLR2A ZBTB10 DNAJC6 LEPROT RNU2-15P LEPR COX6CP13 lnc-JAK1-8
GH01J065247 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 500.7 +0.8 789 3.7 CTBP1 RBM25 FOXA2 ZNF316 NFIC NR2F2 BCOR FOXA1 DPF2 RFX5 DNAJC6 lnc-JAK1-8 COX6CP13
GH01J065277 Enhancer 1.2 ENCODE CraniofacialAtlas dbSUPER 22.1 +30.6 30611 1.4 TEAD4 ZIC2 AFF1 MYC CTBP1 HDAC3 HDAC2 NCOR1 ZNF316 NFIC DNAJC6 RNU2-15P LEPR LEPROT AK4 COX6CP13 lnc-JAK1-8 LOC102724416
GH01J065147 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.5 -99.0 -99040 4.6 HNRNPK ZSCAN5C POLR2G ZNF639 ZIC2 POLR2A ZBTB10 ZBTB11 ZNF423 ZBTB26 AK4 lnc-JAK1-7 piR-39329 DNAJC6 RPS29P7 lnc-AK4-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJC6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DNAJC6

Top Transcription factor binding sites by QIAGEN in the DNAJC6 gene promoter:
  • AML1a
  • C/EBPalpha
  • CHOP-10
  • COMP1
  • FOXJ2
  • FOXJ2 (long isoform)
  • HEN1
  • Lhx3a
  • LHX3b

Genomic Locations for DNAJC6 Gene

Genomic Locations for DNAJC6 Gene
chr1:65,248,148-65,415,871
(GRCh38/hg38)
Size:
167,724 bases
Orientation:
Plus strand
chr1:65,713,902-65,881,552
(GRCh37/hg19)
Size:
167,651 bases
Orientation:
Plus strand

Genomic View for DNAJC6 Gene

Genes around DNAJC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC6 Gene

Proteins for DNAJC6 Gene

  • Protein details for DNAJC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75061-AUXI_HUMAN
    Recommended name:
    Putative tyrosine-protein phosphatase auxilin
    Protein Accession:
    O75061
    Secondary Accessions:
    • B7Z3V8
    • D3DQ65
    • D3DQ66
    • Q32M66
    • Q4G0K1
    • Q5T614
    • Q5T615

    Protein attributes for DNAJC6 Gene

    Size:
    913 amino acids
    Molecular mass:
    99997 Da
    Quaternary structure:
    • Interacts with HSPA8/HSC70. Interacts with CLTC. Interacts with AP2A2 (By similarity).
    SequenceCaution:
    • Sequence=BAA32318.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJC6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC6 Gene

Post-translational modifications for DNAJC6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC6 Gene

No data available for DME Specific Peptides for DNAJC6 Gene

Domains & Families for DNAJC6 Gene

Gene Families for DNAJC6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for DNAJC6 Gene

Suggested Antigen Peptide Sequences for DNAJC6 Gene

GenScript: Design optimal peptide antigens:
  • DnaJ homolog subfamily C member 6 (AUXI_HUMAN)
genes like me logo Genes that share domains with DNAJC6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DNAJC6 Gene

Function for DNAJC6 Gene

Molecular function for DNAJC6 Gene

UniProtKB/Swiss-Prot Function:
Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;.

Enzyme Numbers (IUBMB) for DNAJC6 Gene

Phenotypes From GWAS Catalog for DNAJC6 Gene

Gene Ontology (GO) - Molecular Function for DNAJC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0017124 SH3 domain binding IEA --
GO:0030276 clathrin binding IBA 21873635
genes like me logo Genes that share ontologies with DNAJC6: view
genes like me logo Genes that share phenotypes with DNAJC6: view

Human Phenotype Ontology for DNAJC6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DNAJC6 Gene

MGI Knock Outs for DNAJC6:

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for DNAJC6 Gene

Localization for DNAJC6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC6 gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 3
cytoskeleton 2
mitochondrion 2
endosome 2
lysosome 2
golgi apparatus 2
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNAJC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0014069 postsynaptic density IBA 21873635
GO:0031982 vesicle IBA 21873635
GO:0043231 intracellular membrane-bounded organelle IBA 21873635
genes like me logo Genes that share ontologies with DNAJC6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DNAJC6 Gene

Pathways & Interactions for DNAJC6 Gene

genes like me logo Genes that share pathways with DNAJC6: view

Pathways by source for DNAJC6 Gene

Gene Ontology (GO) - Biological Process for DNAJC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0006898 receptor-mediated endocytosis IBA 21873635
GO:0016191 synaptic vesicle uncoating ISS,IBA 20160091
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with DNAJC6: view

No data available for SIGNOR curated interactions for DNAJC6 Gene

Drugs & Compounds for DNAJC6 Gene

(2) Drugs for DNAJC6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for DNAJC6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with DNAJC6: view

Transcripts for DNAJC6 Gene

mRNA/cDNA for DNAJC6 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - - - - - - - - - -
SP5:
SP6:
SP7:

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b
SP1:
SP2:
SP3:
SP4: - - -
SP5:
SP6:
SP7:

Relevant External Links for DNAJC6 Gene

GeneLoc Exon Structure for
DNAJC6

Expression for DNAJC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJC6 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.7), Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Substantia nigra (x4.6), Brain - Hypothalamus (x4.5), Brain - Spinal cord (cervical c-1) (x4.3), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for DNAJC6 Gene

This gene is overexpressed in Frontal cortex (30.9), Brain (19.0), and Fetal Brain (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DNAJC6 Gene



Protein tissue co-expression partners for DNAJC6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DNAJC6

SOURCE GeneReport for Unigene cluster for DNAJC6 Gene:

Hs.647643

mRNA Expression by UniProt/SwissProt for DNAJC6 Gene:

O75061-AUXI_HUMAN
Tissue specificity: Expressed in various brain regions, including cerebellum, corpus callosum, cortex, striatum, brainstem, pons, putamen, spinal cord and substantia nigra. Very low expression in non-neural tissues such as leukocytes, liver, adipose tissue, skeletal muscle and bone marrow.

Evidence on tissue expression from TISSUES for DNAJC6 Gene

  • Nervous system(5)
  • Liver(4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC6 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • eye
  • eyelid
  • face
  • head
Limb:
  • lower limb
General:
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with DNAJC6: view

Orthologs for DNAJC6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC6 31 30
  • 99.28 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJC6 31 30
  • 92.2 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC6 31 30
  • 91.99 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc6 30
  • 87.65 (n)
mouse
(Mus musculus)
Mammalia Dnajc6 17 31 30
  • 87.57 (n)
oppossum
(Monodelphis domestica)
Mammalia DNAJC6 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC6 31
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJC6 31 30
  • 74.12 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC6 31
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc6 30
  • 69.98 (n)
zebrafish
(Danio rerio)
Actinopterygii dnajc6 31 30
  • 65.96 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta aux 31
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-83 31
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWA2 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10856 31
  • 25 (a)
OneToMany
Species where no ortholog for DNAJC6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC6 Gene

ENSEMBL:
Gene Tree for DNAJC6 (if available)
TreeFam:
Gene Tree for DNAJC6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DNAJC6: view image

Paralogs for DNAJC6 Gene

Paralogs for DNAJC6 Gene

(1) SIMAP similar genes for DNAJC6 Gene using alignment to 3 proteins:

  • AUXI_HUMAN
  • L0N9S0_HUMAN
  • S4R305_HUMAN
genes like me logo Genes that share paralogs with DNAJC6: view

Variants for DNAJC6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DNAJC6 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
641135 Uncertain Significance: Parkinson disease 19a, juvenile-onset 65,309,920(+) A/G MISSENSE_VARIANT,INTRON_VARIANT
648740 Uncertain Significance: Parkinson disease 19a, juvenile-onset 65,405,867(+) T/C INTRON_VARIANT
663145 Uncertain Significance: Parkinson disease 19a, juvenile-onset 65,366,050(+) A/T MISSENSE_VARIANT
664983 Uncertain Significance: Parkinson disease 19a, juvenile-onset 65,309,915(+) G/T MISSENSE_VARIANT,INTRON_VARIANT
702187 Benign: not provided 65,389,382(+) A/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for DNAJC6 Gene

Structural Variations from Database of Genomic Variants (DGV) for DNAJC6 Gene

Variant ID Type Subtype PubMed ID
dgv174n100 CNV gain 25217958
dgv44e212 CNV loss 25503493
esv2676423 CNV deletion 23128226
esv2749207 CNV deletion 23290073
esv3586278 CNV loss 21293372
esv3586279 CNV loss 21293372
esv3586280 CNV loss 21293372
esv3586281 CNV loss 21293372
esv3586282 CNV gain 21293372
nsv472107 CNV novel sequence insertion 20440878
nsv528808 CNV gain 19592680
nsv546438 CNV gain 21841781
nsv830070 CNV gain 17160897
nsv997944 CNV gain 25217958

Variation tolerance for DNAJC6 Gene

Residual Variation Intolerance Score: 4.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJC6 Gene

Human Gene Mutation Database (HGMD)
DNAJC6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC6 Gene

Disorders for DNAJC6 Gene

MalaCards: The human disease database

(10) MalaCards diseases for DNAJC6 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

AUXI_HUMAN
  • Parkinson disease 19A, juvenile-onset (PARK19A) [MIM:615528]: A juvenile form of Parkinson disease, a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK19A is characterized by onset of parkinsonian symptoms in the first or second decade of life. Some patients may have additional neurologic features, including mental retardation and seizures. {ECO:0000269 PubMed:22563501, ECO:0000269 PubMed:23211418, ECO:0000269 PubMed:26703368}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Parkinson disease 19B, early-onset (PARK19B) [MIM:615528]: An early-onset form of Parkinson disease, a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK19B is characterized by symptoms onset in the third-to-fifth decade, slow disease progression, and prominent. response to dopaminergic therapies. Inheritance is autosomal recessive. {ECO:0000269 PubMed:26528954}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for DNAJC6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DNAJC6: view

No data available for Genatlas for DNAJC6 Gene

Publications for DNAJC6 Gene

  1. A deleterious mutation in DNAJC6 encoding the neuronal-specific clathrin-uncoating co-chaperone auxilin, is associated with juvenile parkinsonism. (PMID: 22563501) Edvardson S … Elpeleg O (PloS one 2012) 2 3 4 54
  2. DNAJC6 Mutations Associated With Early-Onset Parkinson's Disease. (PMID: 26528954) Olgiati S … Bonifati V (Annals of neurology 2016) 3 4 54
  3. DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability. (PMID: 23211418) Köroğlu Ç … Tolun A (Parkinsonism & related disorders 2013) 3 4 54
  4. A genome-wide association study of the Protein C anticoagulant pathway. (PMID: 22216198) Athanasiadis G … Soria JM (PloS one 2011) 3 41 54
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 41 54

Products for DNAJC6 Gene

Sources for DNAJC6 Gene