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Aliases for DNAJC5B Gene

Aliases for DNAJC5B Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C5 Beta 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 5 Beta 2 3
  • Cysteine String Protein Beta 3 4
  • CSP-Beta 3 4
  • DnaJ Homolog Subfamily C Member 5B 3
  • DnaJ Homolog Subfamily C Member X 3
  • Testicular Tissue Protein Li 55 3
  • Beta Cysteine String Protein 3
  • Beta-CSP 3

External Ids for DNAJC5B Gene

Previous GeneCards Identifiers for DNAJC5B Gene

  • GC08P066984
  • GC08P067096
  • GC08P062423

Summaries for DNAJC5B Gene

Entrez Gene Summary for DNAJC5B Gene

  • This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins that is characterized by an N-terminal DNAJ domain, a linker region, and a cysteine-rich C-terminal domain. The encoded protein, together with heat shock protein 70, is thought to regulate the proper folding of other proteins. The orthologous mouse protein is membrane-associated and is targeted to the trans-golgi network. [provided by RefSeq, Mar 2017]

GeneCards Summary for DNAJC5B Gene

DNAJC5B (DnaJ Heat Shock Protein Family (Hsp40) Member C5 Beta) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. An important paralog of this gene is DNAJC5.

Additional gene information for DNAJC5B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC5B Gene

Genomics for DNAJC5B Gene

GeneHancer (GH) Regulatory Elements for DNAJC5B Gene

Promoters and enhancers for DNAJC5B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J065980 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 661.8 -32.9 -32937 4.1 PKNOX1 SMAD1 STAT5A BMI1 BATF KLF5 IRF4 ZNF207 ZNF143 ATF7 DNAJC5B GC08M065983 PDE7A MTFR1 LINC01299 GC08P065965 LOC105375883
GH08J066021 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 650.4 +7.2 7240 2.3 PKNOX1 FOXA2 NEUROD1 ZNF766 GLIS2 FOS SP5 REST SMARCB1 GLIS1 LOC105375883 DNAJC5B PDE7A MTFR1 ADHFE1 RRS1 RRS1-AS1 GC08P066013 GC08M066012
GH08J066031 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 650.4 +18.2 18150 2.4 CTCF ZBTB6 NFIB ZNF384 RAD21 GATA3 SMC3 ZNF143 PRDM10 FOSL2 DNAJC5B LINC01299 ENSG00000272010 LOC105375883 GC08P066013 GC08M066089
GH08J065979 Promoter 0.5 EPDnew 661.8 -35.9 -35864 0.1 DNAJC5B GC08M065983 GC08P065965
GH08J065836 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.6 -174.9 -174932 7 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 PDE7A MTFR1 C8orf44 DNAJC5B LINC01299 ENSG00000272192 GC08M065824
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJC5B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJC5B gene promoter:
  • FOXJ2 (long isoform)
  • FOXJ2
  • POU2F1a
  • POU2F1
  • RORalpha2
  • TBP
  • AML1a
  • FOXO1a
  • FOXO1

Genomic Locations for DNAJC5B Gene

Genomic Locations for DNAJC5B Gene
85,485 bases
Plus strand
78,965 bases
Plus strand

Genomic View for DNAJC5B Gene

Genes around DNAJC5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC5B Gene

Proteins for DNAJC5B Gene

  • Protein details for DNAJC5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 5B
    Protein Accession:
    Secondary Accessions:
    • Q969Y8

    Protein attributes for DNAJC5B Gene

    199 amino acids
    Molecular mass:
    22496 Da
    Quaternary structure:
    • Interacts with the chaperone complex consisting of HSC70 and SGTA.

neXtProt entry for DNAJC5B Gene

Post-translational modifications for DNAJC5B Gene

  • Palmitoylated. Palmitoylation is not required for membrane association.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC5B Gene

No data available for DME Specific Peptides for DNAJC5B Gene

Domains & Families for DNAJC5B Gene

Gene Families for DNAJC5B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DNAJC5B Gene

Suggested Antigen Peptide Sequences for DNAJC5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJC5B: view

No data available for UniProtKB/Swiss-Prot for DNAJC5B Gene

Function for DNAJC5B Gene

Phenotypes From GWAS Catalog for DNAJC5B Gene

Gene Ontology (GO) - Molecular Function for DNAJC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DNAJC5B: view
genes like me logo Genes that share phenotypes with DNAJC5B: view

Animal Models for DNAJC5B Gene

MGI Knock Outs for DNAJC5B:
  • Dnajc5b Dnajc5b<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJC5B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DNAJC5B Gene

Localization for DNAJC5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC5B Gene

Membrane; Lipid-anchor. Note=May be associated with the trans-Golgi network. {ECO:0000269 PubMed:17034881}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC5B gene
Compartment Confidence
cytosol 3
mitochondrion 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DNAJC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DNAJC5B: view

Pathways & Interactions for DNAJC5B Gene

genes like me logo Genes that share pathways with DNAJC5B: view

Pathways by source for DNAJC5B Gene

1 KEGG pathway for DNAJC5B Gene

Gene Ontology (GO) - Biological Process for DNAJC5B Gene


No data available for SIGNOR curated interactions for DNAJC5B Gene

Drugs & Compounds for DNAJC5B Gene

No Compound Related Data Available

Transcripts for DNAJC5B Gene

mRNA/cDNA for DNAJC5B Gene

Unigene Clusters for DNAJC5B Gene

DnaJ (Hsp40) homolog, subfamily C, member 5 beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJC5B

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC5B Gene

No ASD Table

Relevant External Links for DNAJC5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC5B Gene

mRNA differential expression in normal tissues according to GTEx for DNAJC5B Gene

This gene is overexpressed in Testis (x44.9).

NURSA nuclear receptor signaling pathways regulating expression of DNAJC5B Gene:


SOURCE GeneReport for Unigene cluster for DNAJC5B Gene:


mRNA Expression by UniProt/SwissProt for DNAJC5B Gene:

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with DNAJC5B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC5B Gene

Orthologs for DNAJC5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC5B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNAJC5B 34 33
  • 99.5 (n)
(Canis familiaris)
Mammalia DNAJC5B 34 33
  • 92.46 (n)
(Mus musculus)
Mammalia Dnajc5b 16 34 33
  • 89.61 (n)
(Bos Taurus)
Mammalia DNAJC5B 34 33
  • 89.28 (n)
(Rattus norvegicus)
Mammalia Dnajc5b 33
  • 89.28 (n)
(Ornithorhynchus anatinus)
Mammalia DNAJC5B 34
  • 78 (a)
(Monodelphis domestica)
Mammalia DNAJC5B 34
  • 75 (a)
(Gallus gallus)
Aves DNAJC5B 34 33
  • 74.7 (n)
(Anolis carolinensis)
Reptilia DNAJC5B 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc5b 33
  • 72.65 (n)
(Danio rerio)
Actinopterygii dnajc5b 34 33
  • 70.74 (n)
wufb75d01 33
fruit fly
(Drosophila melanogaster)
Insecta Csp 34
  • 40 (a)
(Caenorhabditis elegans)
Secernentea dnj-14 34
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIS1 34
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8441 34
  • 51 (a)
Cin.11018 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11018 33
Species where no ortholog for DNAJC5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC5B Gene

Gene Tree for DNAJC5B (if available)
Gene Tree for DNAJC5B (if available)
Evolutionary constrained regions (ECRs) for DNAJC5B: view image

Paralogs for DNAJC5B Gene

Paralogs for DNAJC5B Gene

(19) SIMAP similar genes for DNAJC5B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DNAJC5B: view

Variants for DNAJC5B Gene

Sequence variations from dbSNP and Humsavar for DNAJC5B Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs143168011 uncertain-significance, not specified 66,080,470(+) G/A/T coding_sequence_variant, missense_variant, stop_gained
rs1000001335 -- 66,049,947(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000049226 -- 66,029,232(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000060545 -- 66,086,461(+) C/T intron_variant
rs1000066140 -- 66,035,506(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC5B Gene

Variant ID Type Subtype PubMed ID
esv2657842 CNV deletion 23128226
esv3572797 CNV loss 25503493
esv3617475 CNV loss 21293372

Variation tolerance for DNAJC5B Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJC5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC5B Gene

Disorders for DNAJC5B Gene

Additional Disease Information for DNAJC5B

No disorders were found for DNAJC5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC5B Gene

Publications for DNAJC5B Gene

  1. Cysteine-string protein isoform beta (Cspbeta) is targeted to the trans-Golgi network as a non-palmitoylated CSP in clonal beta-cells. (PMID: 17034881) Boal F … Lang J (Biochimica et biophysica acta 2007) 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Heat shock proteins HSPB8 and DNAJC5B have HCV antiviral activity. (PMID: 29182667) Braga ACS … Rahal P (PloS one 2017) 3 58
  5. Down-regulation of HSP40 gene family following OCT4B1 suppression in human tumor cell lines. (PMID: 27081464) Mirzaei MR … Ahmadi Z (Iranian journal of basic medical sciences 2016) 3 58

Products for DNAJC5B Gene

Sources for DNAJC5B Gene

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