Aliases for DNAJC5 Gene
External Ids for DNAJC5 Gene
Previous HGNC Symbols for DNAJC5 Gene
Previous GeneCards Identifiers for DNAJC5 Gene
This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010]
GeneCards Summary for DNAJC5 Gene
DNAJC5 (DnaJ Heat Shock Protein Family (Hsp40) Member C5) is a Protein Coding gene. Diseases associated with DNAJC5 include Ceroid Lipofuscinosis, Neuronal, 4B, Autosomal Dominant and Ceroid Storage Disease. Among its related pathways are Regulation of degradation of deltaF508 CFTR in CF and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ATP-dependent protein binding. An important paralog of this gene is DNAJC5B.
UniProtKB/Swiss-Prot Summary for DNAJC5 Gene
Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).