Aliases for DNAJC5 Gene
External Ids for DNAJC5 Gene
Previous HGNC Symbols for DNAJC5 Gene
Previous GeneCards Identifiers for DNAJC5 Gene
This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010]
GeneCards Summary for DNAJC5 Gene
DNAJC5 (DnaJ Heat Shock Protein Family (Hsp40) Member C5) is a Protein Coding gene. Diseases associated with DNAJC5 include Ceroid Lipofuscinosis, Neuronal, 4B, Autosomal Dominant and Adult Neuronal Ceroid Lipofuscinosis. Among its related pathways are Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) and Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include ATP-dependent protein binding. An important paralog of this gene is DNAJC5B.
UniProtKB/Swiss-Prot Summary for DNAJC5 Gene
Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).