Aliases for DNAJC4 Gene

Aliases for DNAJC4 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C4 2 3 5
  • MCG18 2 3 4
  • Multiple Endocrine Neoplasia Type 1 Candidate Protein Number 18 3 4
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 4 2 3
  • DnaJ Homolog Subfamily C Member 4 3 4
  • DnaJ-Like Protein HSPF2 3 4
  • HSPF2 3 4
  • Heat Shock 40kD Protein 2 3
  • DANJC4 3
  • DNAJC4 5

External Ids for DNAJC4 Gene

Previous HGNC Symbols for DNAJC4 Gene

  • HSPF2

Previous GeneCards Identifiers for DNAJC4 Gene

  • GC11P066510
  • GC11P065679
  • GC11P064249
  • GC11P063773
  • GC11P063754
  • GC11P063997
  • GC11P060325

Summaries for DNAJC4 Gene

GeneCards Summary for DNAJC4 Gene

DNAJC4 (DnaJ Heat Shock Protein Family (Hsp40) Member C4) is a Protein Coding gene. Diseases associated with DNAJC4 include 3-Methylglutaconic Aciduria, Type V. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is DNAJC25.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DNAJC4 Gene

Genomics for DNAJC4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DNAJC4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJC4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DNAJC4

Top Transcription factor binding sites by QIAGEN in the DNAJC4 gene promoter:
  • AP-2alpha
  • CP2
  • ER-alpha
  • Max1
  • NF-kappaB1
  • Pax-2
  • Pax-2a
  • Pax-5
  • RFX1
  • SEF-1 (1)

Genomic Locations for DNAJC4 Gene

Latest Assembly
4,009 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
3,850 bases
Plus strand

(GRCh37/hg19 by Ensembl)
4,009 bases
Plus strand

Genomic View for DNAJC4 Gene

Genes around DNAJC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC4 Gene

Proteins for DNAJC4 Gene

  • Protein details for DNAJC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 4
    Protein Accession:
    Secondary Accessions:
    • O14716

    Protein attributes for DNAJC4 Gene

    241 amino acids
    Molecular mass:
    27593 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB82426.1; Type=Miscellaneous discrepancy; Note=Several sequence rearrangements.; Evidence={ECO:0000305};

neXtProt entry for DNAJC4 Gene

Post-translational modifications for DNAJC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DNAJC4 Gene

Domains & Families for DNAJC4 Gene

Gene Families for DNAJC4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DNAJC4 Gene


Suggested Antigen Peptide Sequences for DNAJC4 Gene

GenScript: Design optimal peptide antigens:
  • Multiple endocrine neoplasia type 1 candidate protein number 18 (DNJC4_HUMAN)
  • DNAJC4 protein (Q6PIN0_HUMAN)
  • DNAJC4 protein (Q86VG4_HUMAN)
genes like me logo Genes that share domains with DNAJC4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DNAJC4 Gene

Function for DNAJC4 Gene

Phenotypes From GWAS Catalog for DNAJC4 Gene

Gene Ontology (GO) - Molecular Function for DNAJC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17500595
GO:0051082 unfolded protein binding NAS 9473517
genes like me logo Genes that share ontologies with DNAJC4: view
genes like me logo Genes that share phenotypes with DNAJC4: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJC4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DNAJC4 Gene

Localization for DNAJC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC4 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC4 gene
Compartment Confidence
mitochondrion 3
nucleus 1
plasma membrane 0
extracellular 0
cytoskeleton 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for DNAJC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,NAS 9473517
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DNAJC4 Gene

Pathways & Interactions for DNAJC4 Gene

PathCards logo

SuperPathways for DNAJC4 Gene

No Data Available

Interacting Proteins for DNAJC4 Gene

Gene Ontology (GO) - Biological Process for DNAJC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding NAS 9473517
GO:0006986 response to unfolded protein TAS 9473517
genes like me logo Genes that share ontologies with DNAJC4: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC4 Gene

Drugs & Compounds for DNAJC4 Gene

No Compound Related Data Available

Transcripts for DNAJC4 Gene

mRNA/cDNA for DNAJC4 Gene

10 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJC4

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - -
SP8: - -
SP9: - - - - - - - - - - -
SP11: -
SP13: - - - - - - - - - - - - - -

Relevant External Links for DNAJC4 Gene

GeneLoc Exon Structure for

Expression for DNAJC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJC4 Gene

This gene is overexpressed in Testis (x4.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DNAJC4

SOURCE GeneReport for Unigene cluster for DNAJC4 Gene:


Evidence on tissue expression from TISSUES for DNAJC4 Gene

  • Nervous system(4.3)
  • Lung(2.9)
genes like me logo Genes that share expression patterns with DNAJC4: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC4 Gene

Orthologs for DNAJC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNAJC4 30 31
  • 99.45 (n)
(Canis familiaris)
Mammalia DNAJC4 30 31
  • 84.94 (n)
(Bos Taurus)
Mammalia DNAJC4 30 31
  • 84.6 (n)
(Rattus norvegicus)
Mammalia Dnajc4 30
  • 78.48 (n)
(Mus musculus)
Mammalia Dnajc4 30 17 31
  • 78.32 (n)
(Monodelphis domestica)
Mammalia DNAJC4 31
  • 58 (a)
(Anolis carolinensis)
Reptilia DNAJC4 31
  • 41 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dnajc4 30
  • 55.02 (n)
(Danio rerio)
Actinopterygii dnajc4 30 31
  • 55.86 (n)
(Caenorhabditis elegans)
Secernentea dnj-4 31
  • 21 (a)
Species where no ortholog for DNAJC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DNAJC4 Gene

Gene Tree for DNAJC4 (if available)
Gene Tree for DNAJC4 (if available)
Evolutionary constrained regions (ECRs) for DNAJC4: view image

Paralogs for DNAJC4 Gene

(7) SIMAP similar genes for DNAJC4 Gene using alignment to 7 proteins:

  • G3V1T1_HUMAN
  • Q86VG4_HUMAN
  • Q96FY5_HUMAN
genes like me logo Genes that share paralogs with DNAJC4: view

Variants for DNAJC4 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DNAJC4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DNAJC4 Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
dgv1964n54 CNV loss 21841781
esv24861 CNV gain 19812545
esv33033 CNV loss 17666407
esv992196 CNV deletion 20482838
nsv1159904 CNV deletion 26073780
nsv469961 CNV loss 18288195
nsv555184 CNV loss 21841781
nsv555187 CNV loss 21841781
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for DNAJC4 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DNAJC4 Gene

Disorders for DNAJC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJC4 Gene - From: COP

Disorder Aliases PubMed IDs
3-methylglutaconic aciduria, type v
  • mgca5
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DNAJC4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DNAJC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJC4 Gene

Publications for DNAJC4 Gene

  1. Characterisation of a new human and murine member of the DnaJ family of proteins. (PMID: 9473517) Silins G … Hayward N (Biochemical and biophysical research communications 1998) 2 3 4 23
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K … Hata M (Cell stress & chaperones 2000) 2 3

Products for DNAJC4 Gene

Sources for DNAJC4 Gene