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Aliases for DNAJC28 Gene

Aliases for DNAJC28 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C28 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 28 2 3
  • C21orf55 3 4
  • C21orf78 3 4
  • Chromosome 21 Open Reading Frame 55 2
  • DnaJ Homolog Subfamily C Member 28 3
  • Orf28 2

External Ids for DNAJC28 Gene

Previous HGNC Symbols for DNAJC28 Gene

  • C21orf55

Previous GeneCards Identifiers for DNAJC28 Gene

  • GC21M033782
  • GC21M034860
  • GC21M020338

Summaries for DNAJC28 Gene

Entrez Gene Summary for DNAJC28 Gene

  • This gene encodes a member of the DnaJ heat shock protein family. The encoded protein, which contains a conserved N-terminal DnaJ domain, is thought to play a role in protein folding or act as a molecular chaperone protein. [provided by RefSeq, Oct 2016]

GeneCards Summary for DNAJC28 Gene

DNAJC28 (DnaJ Heat Shock Protein Family (Hsp40) Member C28) is a Protein Coding gene. Diseases associated with DNAJC28 include Retinitis Pigmentosa 4 and Chickenpox.

UniProtKB/Swiss-Prot for DNAJC28 Gene

  • May have a role in protein folding or as a chaperone.

Gene Wiki entry for DNAJC28 Gene

Additional gene information for DNAJC28 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC28 Gene

Genomics for DNAJC28 Gene

GeneHancer (GH) Regulatory Elements for DNAJC28 Gene

Promoters and enhancers for DNAJC28 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J033490 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.1 90 1.5 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 DNAJC28 SON PAXBP1 TMEM50B GART DONSON RPS5P2 SMIM34A ENSG00000231355
GH21J033539 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12 -51.3 -51261 6.5 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 NFYC MEF2D SON TMEM50B GART PAXBP1 DONSON CFAP298 PAXBP1-AS1 DNAJC28 ENSG00000231355 RPS5P3
GH21J033400 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 +87.8 87798 6.7 MLX ARID4B SIN3A ZNF2 YY1 SP3 ZC3H11A MXD4 REST SMARCB1 IFNGR2 TMEM50B PAXBP1 IFNAR2 SON GART RPS5P3 ENSG00000231355 ENSG00000249624 DNAJC28
GH21J033196 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +293.1 293109 4.3 PKNOX1 ATF1 ZNF2 BRCA1 YY1 ARID2 ZNF143 FOS ATF7 DEK IFNAR2 PAXBP1 SON GART LINC01548 IFNGR2 ENSG00000249624 ENSG00000226433 DONSON TMEM50B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJC28 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJC28 gene promoter:
  • Arnt
  • GATA-1
  • Pax-6
  • E2F
  • Ik-2
  • E2F-1

Genomic Locations for DNAJC28 Gene

Genomic Locations for DNAJC28 Gene
6,218 bases
Minus strand
3,790 bases
Minus strand

Genomic View for DNAJC28 Gene

Genes around DNAJC28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC28 Gene

Proteins for DNAJC28 Gene

  • Protein details for DNAJC28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 28
    Protein Accession:
    Secondary Accessions:
    • D3DSF2

    Protein attributes for DNAJC28 Gene

    388 amino acids
    Molecular mass:
    45806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DNAJC28 Gene

Post-translational modifications for DNAJC28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC28 Gene

No data available for DME Specific Peptides for DNAJC28 Gene

Domains & Families for DNAJC28 Gene

Gene Families for DNAJC28 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DNAJC28 Gene

Suggested Antigen Peptide Sequences for DNAJC28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJC28: view

No data available for UniProtKB/Swiss-Prot for DNAJC28 Gene

Function for DNAJC28 Gene

Molecular function for DNAJC28 Gene

UniProtKB/Swiss-Prot Function:
May have a role in protein folding or as a chaperone.

Phenotypes From GWAS Catalog for DNAJC28 Gene

Gene Ontology (GO) - Molecular Function for DNAJC28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24407287
genes like me logo Genes that share ontologies with DNAJC28: view
genes like me logo Genes that share phenotypes with DNAJC28: view

Animal Models for DNAJC28 Gene

MGI Knock Outs for DNAJC28:

Animal Model Products

CRISPR Products

miRNA for DNAJC28 Gene

miRTarBase miRNAs that target DNAJC28

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJC28

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJC28 Gene

Localization for DNAJC28 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC28 gene
Compartment Confidence
golgi apparatus 4
mitochondrion 3
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for DNAJC28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017119 Golgi transport complex IBA --
genes like me logo Genes that share ontologies with DNAJC28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for DNAJC28 Gene

Pathways & Interactions for DNAJC28 Gene

SuperPathways for DNAJC28 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000301 retrograde transport, vesicle recycling within Golgi IBA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IBA --
GO:0007030 Golgi organization IBA --
GO:0048213 Golgi vesicle prefusion complex stabilization IBA --
genes like me logo Genes that share ontologies with DNAJC28: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC28 Gene

Drugs & Compounds for DNAJC28 Gene

No Compound Related Data Available

Transcripts for DNAJC28 Gene

mRNA/cDNA for DNAJC28 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNAJC28 Gene

DnaJ (Hsp40) homolog, subfamily C, member 28:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJC28

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC28 Gene

No ASD Table

Relevant External Links for DNAJC28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJC28 Gene

This gene is overexpressed in Testis (x4.1).

Protein differential expression in normal tissues from HIPED for DNAJC28 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DNAJC28 Gene

Protein tissue co-expression partners for DNAJC28 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC28 Gene:


SOURCE GeneReport for Unigene cluster for DNAJC28 Gene:


mRNA Expression by UniProt/SwissProt for DNAJC28 Gene:

Tissue specificity: Expressed in the fetal and adult brain, testis, uterus, spleen and liver.
genes like me logo Genes that share expression patterns with DNAJC28: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC28 Gene

Orthologs for DNAJC28 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC28 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNAJC28 34 33
  • 99.48 (n)
(Bos Taurus)
Mammalia DNAJC28 34 33
  • 88.3 (n)
(Canis familiaris)
Mammalia LOC100856290 33
  • 87.88 (n)
-- 34
  • 82 (a)
-- 34
  • 82 (a)
(Mus musculus)
Mammalia Dnajc28 16 34 33
  • 78.57 (n)
(Rattus norvegicus)
Mammalia Dnajc28 33
  • 78.39 (n)
(Ornithorhynchus anatinus)
Mammalia DNAJC28 34
  • 68 (a)
(Monodelphis domestica)
Mammalia DNAJC28 34
  • 67 (a)
(Gallus gallus)
Aves C21ORF55 33
  • 67.39 (n)
DNAJC28 34
  • 57 (a)
(Anolis carolinensis)
Reptilia DNAJC28 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc28 33
  • 63.51 (n)
(Danio rerio)
Actinopterygii dnajc28 34 33
  • 55.04 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009787 33
  • 50.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG43322 34 33
  • 49.01 (n)
Species where no ortholog for DNAJC28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJC28 Gene

Gene Tree for DNAJC28 (if available)
Gene Tree for DNAJC28 (if available)
Evolutionary constrained regions (ECRs) for DNAJC28: view image

Paralogs for DNAJC28 Gene

No data available for Paralogs for DNAJC28 Gene

Variants for DNAJC28 Gene

Sequence variations from dbSNP and Humsavar for DNAJC28 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs147358478 uncertain-significance, not specified 33,488,892(-) C/A/G coding_sequence_variant, missense_variant, stop_gained
rs1000974058 -- 33,490,077(-) G/A intron_variant
rs1001028126 -- 33,489,742(-) G/A intron_variant
rs1001424873 -- 33,487,771(-) A/G downstream_transcript_variant
rs1002206205 -- 33,489,492(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC28 Gene

Variant ID Type Subtype PubMed ID
nsv191 CNV insertion 15895083
nsv3497 CNV insertion 18451855
nsv509795 CNV insertion 20534489
nsv524420 CNV loss 19592680

Variation tolerance for DNAJC28 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.97; 79.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJC28 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC28 Gene

Disorders for DNAJC28 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DNAJC28 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 4
  • rp4
  • varicella
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DNAJC28

genes like me logo Genes that share disorders with DNAJC28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJC28 Gene

Publications for DNAJC28 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PMID: 12036298) Gardiner K … Davisson M (Genomics 2002) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld CA … Koellinger PD (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 58

Products for DNAJC28 Gene

Sources for DNAJC28 Gene

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