This gene represents naturally-occurring mRNAs that are co-transcribed products of the neighboring DNAJC25 and GNG10 genes. These transcripts include the first exon of DNAJC25 and the last two exons of GNG10, resulting in a protein that combines the N-terminus of DNAJC25 and the C-terminus of GNG10. [provided by RefSeq, Dec 2008] See more...

Aliases for DNAJC25-GNG10 Gene

Aliases for DNAJC25-GNG10 Gene

  • DNAJC25-GNG10 Readthrough 2 3 5
  • Guanine Nucleotide-Binding Protein Subunit Gamma 13
  • DNAJC25-GNG10 Readthrough Transcript 3
  • DNAJC25-GNG10 Protein 3
  • DNAJC25-GNG10 5

External Ids for DNAJC25-GNG10 Gene

Previous GeneCards Identifiers for DNAJC25-GNG10 Gene

  • GC09P113445
  • GC09P113447
  • GC09P114394
  • GC09P083993

Summaries for DNAJC25-GNG10 Gene

Entrez Gene Summary for DNAJC25-GNG10 Gene

  • This gene represents naturally-occurring mRNAs that are co-transcribed products of the neighboring DNAJC25 and GNG10 genes. These transcripts include the first exon of DNAJC25 and the last two exons of GNG10, resulting in a protein that combines the N-terminus of DNAJC25 and the C-terminus of GNG10. [provided by RefSeq, Dec 2008]

GeneCards Summary for DNAJC25-GNG10 Gene

DNAJC25-GNG10 (DNAJC25-GNG10 Readthrough) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is DNAJC25.

Additional gene information for DNAJC25-GNG10 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DNAJC25-GNG10 Gene

Genomics for DNAJC25-GNG10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DNAJC25-GNG10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJC25-GNG10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DNAJC25-GNG10

Top Transcription factor binding sites by QIAGEN in the DNAJC25-GNG10 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • CREB
  • deltaCREB
  • ER-alpha
  • FOXI1
  • HFH-3
  • HSF2
  • p300
  • Sox5

Genomic Locations for DNAJC25-GNG10 Gene

Genomic Locations for DNAJC25-GNG10 Gene
chr9:111,631,334-111,670,229
(GRCh38/hg38)
Size:
38,896 bases
Orientation:
Plus strand
chr9:114,393,632-114,432,526
(GRCh37/hg19)
Size:
38,895 bases
Orientation:
Plus strand

Genomic View for DNAJC25-GNG10 Gene

Genes around DNAJC25-GNG10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC25-GNG10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC25-GNG10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC25-GNG10 Gene

Proteins for DNAJC25-GNG10 Gene

  • Protein details for DNAJC25-GNG10 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024R161-A0A024R161_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein subunit gamma
    Protein Accession:
    A0A024R161

    Protein attributes for DNAJC25-GNG10 Gene

    Size:
    153 amino acids
    Molecular mass:
    16499 Da
    Quaternary structure:
    • G proteins are composed of 3 units; alpha, beta and gamma.

neXtProt entry for DNAJC25-GNG10 Gene

Protein Expression for DNAJC25-GNG10 Gene

Post-translational modifications for DNAJC25-GNG10 Gene

No Post-translational modifications

Other Protein References for DNAJC25-GNG10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC25-GNG10 Gene

Domains & Families for DNAJC25-GNG10 Gene

Gene Families for DNAJC25-GNG10 Gene

Unknown:
  • Belongs to the G protein gamma family.
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DNAJC25-GNG10 Gene

genes like me logo Genes that share domains with DNAJC25-GNG10: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DNAJC25-GNG10 Gene

Function for DNAJC25-GNG10 Gene

Molecular function for DNAJC25-GNG10 Gene

UniProtKB/TrEMBL Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
  • A0A024R161

Phenotypes From GWAS Catalog for DNAJC25-GNG10 Gene

Gene Ontology (GO) - Molecular Function for DNAJC25-GNG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0031681 G-protein beta-subunit binding IBA --
genes like me logo Genes that share ontologies with DNAJC25-GNG10: view
genes like me logo Genes that share phenotypes with DNAJC25-GNG10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJC25-GNG10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DNAJC25-GNG10 Gene

Localization for DNAJC25-GNG10 Gene

Gene Ontology (GO) - Cellular Components for DNAJC25-GNG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0031680 G-protein beta/gamma-subunit complex IBA --
genes like me logo Genes that share ontologies with DNAJC25-GNG10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for DNAJC25-GNG10 Gene

Pathways & Interactions for DNAJC25-GNG10 Gene

PathCards logo

SuperPathways for DNAJC25-GNG10 Gene

No Data Available

Interacting Proteins for DNAJC25-GNG10 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000363412 for DNAJC25-GNG10 Gene via STRING

GPS-Prot Interaction Network for DNAJC25-GNG10

Gene Ontology (GO) - Biological Process for DNAJC25-GNG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with DNAJC25-GNG10: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC25-GNG10 Gene

Drugs & Compounds for DNAJC25-GNG10 Gene

No Compound Related Data Available

Transcripts for DNAJC25-GNG10 Gene

mRNA/cDNA for DNAJC25-GNG10 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJC25-GNG10

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC25-GNG10 Gene

No ASD Table

Relevant External Links for DNAJC25-GNG10 Gene

GeneLoc Exon Structure for
DNAJC25-GNG10

Expression for DNAJC25-GNG10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJC25-GNG10 Gene

mRNA expression in normal human tissues for DNAJC25-GNG10 Gene

Protein differential expression in normal tissues from HIPED for DNAJC25-GNG10 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for DNAJC25-GNG10 Gene



Protein tissue co-expression partners for DNAJC25-GNG10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DNAJC25-GNG10

genes like me logo Genes that share expression patterns with DNAJC25-GNG10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC25-GNG10 Gene

Orthologs for DNAJC25-GNG10 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC25-GNG10 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Gm20503 31
  • 85 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 43 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC25 31
  • 21 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 22 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 20 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii dnajc25 31
  • 20 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG7872 31
  • 17 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea dnj-2 31
  • 13 (a)
ManyToMany
C47A4.1 31
  • 1 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 4 (a)
OneToMany
Species where no ortholog for DNAJC25-GNG10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for DNAJC25-GNG10 Gene

ENSEMBL:
Gene Tree for DNAJC25-GNG10 (if available)
TreeFam:
Gene Tree for DNAJC25-GNG10 (if available)

Paralogs for DNAJC25-GNG10 Gene

genes like me logo Genes that share paralogs with DNAJC25-GNG10: view

Variants for DNAJC25-GNG10 Gene

Additional dbSNP identifiers (rs#s) for DNAJC25-GNG10 Gene

Structural Variations from Database of Genomic Variants (DGV) for DNAJC25-GNG10 Gene

Variant ID Type Subtype PubMed ID
dgv7700n100 CNV gain 25217958
nsv466486 CNV gain 19166990
nsv615192 CNV loss 21841781
nsv615193 CNV gain 21841781
nsv825041 CNV gain 20364138

Variation tolerance for DNAJC25-GNG10 Gene

Gene Damage Index Score: 0.01; 0.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJC25-GNG10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC25-GNG10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DNAJC25-GNG10 Gene

Disorders for DNAJC25-GNG10 Gene

Additional Disease Information for DNAJC25-GNG10

No disorders were found for DNAJC25-GNG10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC25-GNG10 Gene

Publications for DNAJC25-GNG10 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 13
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for DNAJC25-GNG10 Gene

Sources for DNAJC25-GNG10 Gene