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This gene represents naturally-occurring mRNAs that are co-transcribed products of the neighboring DNAJC25 and GNG10 genes. These transcripts include the first exon of DNAJC25 and the last two exons of GNG10, resulting in a protein that combines the N-terminus of DNAJC25 and the C-terminus of GNG10. [provided by RefSeq, Dec 2008] See more...
Aliases for DNAJC25-GNG10 Gene
Aliases for DNAJC25-GNG10 Gene
External Ids for DNAJC25-GNG10 Gene
- HGNC: 37501
- Entrez Gene: 552891
- Ensembl: ENSG00000244115
- UniProtKB: A0A024R161
Previous GeneCards Identifiers for DNAJC25-GNG10 Gene
- GC09P113445
- GC09P113447
- GC09P114394
- GC09P083993
Summaries for DNAJC25-GNG10 Gene
-
This gene represents naturally-occurring mRNAs that are co-transcribed products of the neighboring DNAJC25 and GNG10 genes. These transcripts include the first exon of DNAJC25 and the last two exons of GNG10, resulting in a protein that combines the N-terminus of DNAJC25 and the C-terminus of GNG10. [provided by RefSeq, Dec 2008]
GeneCards Summary for DNAJC25-GNG10 Gene
DNAJC25-GNG10 (DNAJC25-GNG10 Readthrough) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is DNAJC25.
Additional gene information for DNAJC25-GNG10 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DNAJC25-GNG10 Gene
Genomics for DNAJC25-GNG10 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DNAJC25-GNG10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DNAJC25-GNG10 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DNAJC25-GNG10
- Top Transcription factor binding sites by QIAGEN in the DNAJC25-GNG10 gene promoter:
-
- C/EBPalpha
- CHOP-10
- CREB
- deltaCREB
- ER-alpha
- FOXI1
- HFH-3
- HSF2
- p300
- Sox5
Genomic Locations for DNAJC25-GNG10 Gene
Genomic Locations for DNAJC25-GNG10 Gene
- chr9:111,631,334-111,670,229
- (GRCh38/hg38)
- Size:
- 38,896 bases
- Orientation:
- Plus strand
- chr9:114,393,632-114,432,526
- (GRCh37/hg19)
- Size:
- 38,895 bases
- Orientation:
- Plus strand
Genomic View for DNAJC25-GNG10 Gene
Genes around DNAJC25-GNG10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q31.3 by HGNC
- 9q31.3 by Entrez Gene
- 9q31.3 by Ensembl
DNAJC25-GNG10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DNAJC25-GNG10 Gene
Proteins for DNAJC25-GNG10 Gene
-
Protein details for DNAJC25-GNG10 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A024R161-A0A024R161_HUMAN
- Recommended name:
- Guanine nucleotide-binding protein subunit gamma
- Protein Accession:
- A0A024R161
Protein attributes for DNAJC25-GNG10 Gene
- Size:
- 153 amino acids
- Molecular mass:
- 16499 Da
- Quaternary structure:
-
- G proteins are composed of 3 units; alpha, beta and gamma.
Protein Expression for DNAJC25-GNG10 Gene
Post-translational modifications for DNAJC25-GNG10 Gene
No Post-translational modifications
Other Protein References for DNAJC25-GNG10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-DNAJC25-GNG10 monoclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for DNAJC25-GNG10
- Novus Biologicals Antibodies for DNAJC25-GNG10
- antibodies-online: Show 4 available DNAJC25-GNG10 Antibodies ranked by validation data
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DNAJC25-GNG10
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No data available for DME Specific Peptides for DNAJC25-GNG10 Gene
Domains & Families for DNAJC25-GNG10 Gene
Gene Families for DNAJC25-GNG10 Gene
- Unknown:
-
- Belongs to the G protein gamma family.
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for DNAJC25-GNG10 Gene
- InterPro:
- ProtoNet:
No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DNAJC25-GNG10 Gene
Function for DNAJC25-GNG10 Gene
Molecular function for DNAJC25-GNG10 Gene
- UniProtKB/TrEMBL Function:
-
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
- A0A024R161
Phenotypes From GWAS Catalog for DNAJC25-GNG10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003924 | GTPase activity | IEA | -- |
| GO:0031681 | G-protein beta-subunit binding | IBA | -- |
Phenotypes for DNAJC25-GNG10 Gene
- GenomeRNAi human phenotypes for DNAJC25-GNG10:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DNAJC25-GNG10 - Select products 50% OFF >
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-
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-
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miRNA Products
Inhibitory RNA Products
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Clone Products
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-
OriGene ORF clones in human for DNAJC25-GNG10
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Cell Line Products
-
Horizon Cell Lines for DNAJC25-GNG10
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DNAJC25-GNG10 Gene
Localization for DNAJC25-GNG10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005834 | heterotrimeric G-protein complex | IBA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0031680 | G-protein beta/gamma-subunit complex | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for DNAJC25-GNG10 Gene
Pathways & Interactions for DNAJC25-GNG10 Gene
Interacting Proteins for DNAJC25-GNG10 Gene
GPS-Prot Interaction Network for DNAJC25-GNG10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for DNAJC25-GNG10 Gene
Transcripts for DNAJC25-GNG10 Gene
mRNA/cDNA for DNAJC25-GNG10 Gene
- 1 REFSEQ mRNAs :
- 3 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000374294 1448 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DNAJC25-GNG10 - Select products 50% OFF >
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-
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-
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miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for DNAJC25-GNG10 - Select products 50% OFF >
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-
OriGene ORF clones in human for DNAJC25-GNG10
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Relevant External Links for DNAJC25-GNG10 Gene
- GeneLoc Exon Structure for
- DNAJC25-GNG10
Expression for DNAJC25-GNG10 Gene
mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJC25-GNG10 Gene
This gene is overexpressed in Brain (69.0).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DNAJC25-GNG10
Primer Products
-
OriGene qPCR primer pairs for DNAJC25-GNG10
-
OriGene qPCR primer pairs and template standards for DNAJC25-GNG10
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC25-GNG10 Gene
Orthologs for DNAJC25-GNG10 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Mouse (Mus musculus) |
Mammalia | Gm20503 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | DNAJC25 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | dnajc25 31 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG7872 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | dnj-2 31 |
|
ManyToMany | |
| C47A4.1 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for DNAJC25-GNG10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Paralogs for DNAJC25-GNG10 Gene
Paralogs for DNAJC25-GNG10 Gene
Variants for DNAJC25-GNG10 Gene
Gene Damage Index Score:
0.01;
0.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DNAJC25-GNG10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DNAJC25-GNG10
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DNAJC25-GNG10 Gene
Disorders for DNAJC25-GNG10 Gene
Additional Disease Information for DNAJC25-GNG10
No disorders were found for DNAJC25-GNG10 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC25-GNG10 Gene
Publications for DNAJC25-GNG10 Gene
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 13
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
Products for DNAJC25-GNG10 Gene
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- OriGene qPCR primer pairs for DNAJC25-GNG10
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- VectorBuilder Custom and pre-made DNA vectors for DNAJC25-GNG10 (ie. gene expression, shRNA knockdown, CRISPR)
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Sources for DNAJC25-GNG10 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB