Aliases for DNAJC25 Gene

Aliases for DNAJC25 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C25 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C , Member 25 2 3
  • DnaJ Homolog Subfamily C Member 25 3 4
  • DnaJ-Like Protein 3
  • BA16L21.2.1 3

External Ids for DNAJC25 Gene

Previous GeneCards Identifiers for DNAJC25 Gene

  • GC09P113444
  • GC09P113446
  • GC09P114393
  • GC09P083992

Summaries for DNAJC25 Gene

GeneCards Summary for DNAJC25 Gene

DNAJC25 (DnaJ Heat Shock Protein Family (Hsp40) Member C25) is a Protein Coding gene. An important paralog of this gene is DNAJC25-GNG10.

Additional gene information for DNAJC25 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DNAJC25 Gene

Genomics for DNAJC25 Gene

GeneHancer (GH) Regulatory Elements for DNAJC25 Gene

Promoters and enhancers for DNAJC25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J111630 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 509.8 +0.6 567 3.4 EP300 FOXK2 HNRNPK ZBTB40 ZNF217 ZSCAN5C SIN3A NRF1 TCF12 POLR2G LRRC37A5P DNAJC25 DNAJC25-GNG10 lnc-PTGR1-1 ENSG00000213529 GNG10 piR-52438-117
GH09J111649 Promoter 0.3 EPDnew 500.4 +18.3 18313 0.1 DNAJC25 LRRC37A5P lnc-GNG10-2 piR-49732-605 DNAJC25-GNG10
GH09J112027 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.7 +408.9 408949 24.8 FOXK2 ZNF217 SIN3A TCF12 SP1 NCOR1 JUND TEAD4 FOS EP300 ENSG00000259953 RNU6-710P RNU6-1013P DNAJC25 ENSG00000227531 UGCG GNG10 PTGR1 HSALNG0073743 LOC105376220
GH09J111626 Enhancer 1.1 FANTOM5 Ensembl ENCODE 5.9 -3.5 -3548 2.4 NCOR1 NR2F2 FOXA2 ZBTB33 JUND FOXA1 CTCF RAD21 RXRA ESRRA PTGR1 DNAJC25 LRRC37A5P lnc-PTGR1-1 piR-43099-611
GH09J111942 Enhancer 1.1 Ensembl ENCODE dbSUPER 4.8 +313.1 313127 3.9 EP300 RELA BCL11A TCF12 FOXA2 CBFB ZNF384 POLR2A CEBPB MEF2B UGCG RNU6-710P RNU6-1013P GNG10 DNAJC25 lnc-SUSD1-7 MIR4668
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJC25 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DNAJC25

Top Transcription factor binding sites by QIAGEN in the DNAJC25 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • CREB
  • deltaCREB
  • ER-alpha
  • FOXI1
  • HFH-3
  • HSF2
  • p300
  • Sox5

Genomic Locations for DNAJC25 Gene

Genomic Locations for DNAJC25 Gene
chr9:111,631,334-111,654,351
(GRCh38/hg38)
Size:
23,018 bases
Orientation:
Plus strand
chr9:114,393,632-114,432,508
(GRCh37/hg19)
Size:
38,877 bases
Orientation:
Plus strand

Genomic View for DNAJC25 Gene

Genes around DNAJC25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC25 Gene

Proteins for DNAJC25 Gene

  • Protein details for DNAJC25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1X3-DJC25_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 25
    Protein Accession:
    Q9H1X3
    Secondary Accessions:
    • Q5QTD8
    • Q96BN9

    Protein attributes for DNAJC25 Gene

    Size:
    360 amino acids
    Molecular mass:
    42404 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DNAJC25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC25 Gene

Post-translational modifications for DNAJC25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC25 Gene

Domains & Families for DNAJC25 Gene

Gene Families for DNAJC25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for DNAJC25 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJC25 Gene

GenScript: Design optimal peptide antigens:
  • DnaJ homolog subfamily C member 25 (DJC25_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H1X3

UniProtKB/Swiss-Prot:

DJC25_HUMAN :
  • Belongs to the DNAJC25 family.
Family:
  • Belongs to the DNAJC25 family.
genes like me logo Genes that share domains with DNAJC25: view

Function for DNAJC25 Gene

Phenotypes From GWAS Catalog for DNAJC25 Gene

genes like me logo Genes that share phenotypes with DNAJC25: view

Animal Model Products

CRISPR Products

miRNA for DNAJC25 Gene

miRTarBase miRNAs that target DNAJC25

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC25 Gene

Localization for DNAJC25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC25 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNAJC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC25: view

No data available for Subcellular locations from COMPARTMENTS for DNAJC25 Gene

Pathways & Interactions for DNAJC25 Gene

PathCards logo

SuperPathways for DNAJC25 Gene

No Data Available

Interacting Proteins for DNAJC25 Gene

;

Gene Ontology (GO) - Biological Process for DNAJC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA 21873635
GO:0007186 G protein-coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with DNAJC25: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC25 Gene

Drugs & Compounds for DNAJC25 Gene

No Compound Related Data Available

Transcripts for DNAJC25 Gene

mRNA/cDNA for DNAJC25 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC25 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: -
SP2: - -
SP3:
SP4: - - -
SP5:
SP6:
SP7: - - - - - - - -

Relevant External Links for DNAJC25 Gene

GeneLoc Exon Structure for
DNAJC25

Expression for DNAJC25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJC25 Gene

mRNA differential expression in normal tissues according to GTEx for DNAJC25 Gene

This gene is overexpressed in Liver (x4.2).

Protein differential expression in normal tissues from HIPED for DNAJC25 Gene

This gene is overexpressed in Adrenal (25.2), Bone (8.1), and Liver (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DNAJC25 Gene



Protein tissue co-expression partners for DNAJC25 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DNAJC25

Evidence on tissue expression from TISSUES for DNAJC25 Gene

  • Liver(4.3)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with DNAJC25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC25 Gene

Orthologs for DNAJC25 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC25 31 30
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC25 31 30
  • 92.32 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJC25 31 30
  • 89.79 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc25 17 31 30
  • 87.86 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc25 30
  • 86.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC25 31
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 77 (a)
ManyToMany
-- 31
  • 55 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 31
  • 78 (a)
OneToMany
DNAJC25 30
  • 77.49 (n)
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc25 30
  • 70.36 (n)
zebrafish
(Danio rerio)
Actinopterygii dnajc25 31 30
  • 69.77 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7872 31 30
  • 59.39 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000831 30
  • 54.91 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-2 31 30
  • 50.38 (n)
ManyToMany
C47A4.1 31
  • 34 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G61770 30
  • 46.62 (n)
rice
(Oryza sativa)
Liliopsida Os12g0258200 30
  • 47.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 48 (a)
OneToMany
Species where no ortholog for DNAJC25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC25 Gene

ENSEMBL:
Gene Tree for DNAJC25 (if available)
TreeFam:
Gene Tree for DNAJC25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DNAJC25: view image

Paralogs for DNAJC25 Gene

(3) SIMAP similar genes for DNAJC25 Gene using alignment to 3 proteins:

  • DJC25_HUMAN
  • F2Z3D1_HUMAN
  • J3QR79_HUMAN
genes like me logo Genes that share paralogs with DNAJC25: view

Variants for DNAJC25 Gene

Additional dbSNP identifiers (rs#s) for DNAJC25 Gene

Structural Variations from Database of Genomic Variants (DGV) for DNAJC25 Gene

Variant ID Type Subtype PubMed ID
nsv615192 CNV loss 21841781
nsv825041 CNV gain 20364138

Variation tolerance for DNAJC25 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.49; 71.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJC25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DNAJC25 Gene

Disorders for DNAJC25 Gene

Additional Disease Information for DNAJC25

No disorders were found for DNAJC25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC25 Gene

Publications for DNAJC25 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 54
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for DNAJC25 Gene

Sources for DNAJC25 Gene