Aliases for DNAJC24 Gene
- DnaJ Heat Shock Protein Family (Hsp40) Member C24 2 3 5
- DnaJ (Hsp40) Homolog, Subfamily C, Member 24 2 3
- CSL-Type Zinc Finger-Containing Protein 3 3 4
- Diphthamide Biosynthesis Protein 4 3 4
- DnaJ Homolog Subfamily C Member 24 3 4
- DPH4 Homolog (JJJ3, S. Cerevisiae) 2 3
- Zinc Finger, CSL-Type Containing 3 2 3
External Ids for DNAJC24 Gene
Previous HGNC Symbols for DNAJC24 Gene
Previous GeneCards Identifiers for DNAJC24 Gene
Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]
GeneCards Summary for DNAJC24 Gene
DNAJC24 (DnaJ Heat Shock Protein Family (Hsp40) Member C24) is a Protein Coding gene. Diseases associated with DNAJC24 include Diphtheria and Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome. Among its related pathways are Metabolism of proteins and Gamma carboxylation, hypusine formation and arylsulfatase activation. Gene Ontology (GO) annotations related to this gene include ferrous iron binding and ATPase activator activity. An important paralog of this gene is DNAJC1.
UniProtKB/Swiss-Prot Summary for DNAJC24 Gene
Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).