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Aliases for DNAJC22 Gene

Aliases for DNAJC22 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C22 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 22 2 3
  • DnaJ Homolog Subfamily C Member 22 3 4
  • Wurst Homolog (Drosophila) 2
  • Wurst Homolog 3
  • Wus 3

External Ids for DNAJC22 Gene

Previous GeneCards Identifiers for DNAJC22 Gene

  • GC12P048028
  • GC12P049740
  • GC12P046771

Summaries for DNAJC22 Gene

GeneCards Summary for DNAJC22 Gene

DNAJC22 (DnaJ Heat Shock Protein Family (Hsp40) Member C22) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and chaperone binding.

UniProtKB/Swiss-Prot for DNAJC22 Gene

Additional gene information for DNAJC22 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC22 Gene

Genomics for DNAJC22 Gene

GeneHancer (GH) Regulatory Elements for DNAJC22 Gene

Promoters and enhancers for DNAJC22 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J049348 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 610.1 +1.3 1265 1.7 HDGF CTCF ELF3 POLR2A ZNF121 CEBPG RERE ZSCAN21 AHR TFE3 DNAJC22 CCNT1 KANSL2 DDX23 LOC390314 KMT2D LIMA1 LMBR1L ENSG00000257964 SMARCD1
GH12J049347 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 600.7 +0.1 145 0.4 HDGF ZNF121 KLF14 EGR1 GLIS2 ZBTB8A ZNF600 ZIC2 CTCF PATZ1 DNAJC22 CCNT1 KANSL2 LOC390314 ENSG00000257964 KMT2D DDX23 PRPF40B SPATS2 GC12P049321
GH12J049344 Promoter/Enhancer 1.1 FANTOM5 Ensembl 602.2 -1.6 -1583 0.6 ZBTB8A ZNF341 EZH2 YY1 NR2F1 ZNF335 HIC1 BCL6 GLIS1 ZBTB6 DNAJC22 PRPF40B C1QL4 GC12P049321
GH12J049346 Promoter 1.1 Ensembl 600.7 -0.4 -387 0.6 PRDM1 EGR1 GLIS2 ZBTB8A PRDM10 ZNF512 ZIC2 PATZ1 ZNF341 SP2 DNAJC22 SPATS2 C1QL4 GC12P049321
GH12J049364 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 7.9 +20.7 20744 5.9 SP1 ZFX CC2D1A MNT CBFA2T2 ZNF148 NKRF POLR2A MLLT1 ZNF121 SPATS2 TUBA1A KCNH3 MCRS1 DNAJC22 PRPF40B LOC100335030 GC12P049321
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJC22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJC22 gene promoter:
  • GR
  • GR-alpha
  • GR-beta
  • PPAR-gamma2
  • S8
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3

Genomic Locations for DNAJC22 Gene

Genomic Locations for DNAJC22 Gene
10,659 bases
Plus strand
10,610 bases
Plus strand

Genomic View for DNAJC22 Gene

Genes around DNAJC22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC22 Gene

Proteins for DNAJC22 Gene

  • Protein details for DNAJC22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 22
    Protein Accession:
    Secondary Accessions:
    • B3KP54

    Protein attributes for DNAJC22 Gene

    341 amino acids
    Molecular mass:
    38086 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DNAJC22 Gene

Post-translational modifications for DNAJC22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJC22 Gene

No data available for DME Specific Peptides for DNAJC22 Gene

Domains & Families for DNAJC22 Gene

Gene Families for DNAJC22 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for DNAJC22 Gene


Suggested Antigen Peptide Sequences for DNAJC22 Gene

GenScript: Design optimal peptide antigens:
  • DnaJ homolog subfamily C member 22 (DJC22_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJC22: view

No data available for UniProtKB/Swiss-Prot for DNAJC22 Gene

Function for DNAJC22 Gene

Molecular function for DNAJC22 Gene

UniProtKB/Swiss-Prot Function:
May function as a co-chaperone.

Phenotypes From GWAS Catalog for DNAJC22 Gene

genes like me logo Genes that share phenotypes with DNAJC22: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJC22

Clone Products

  • Applied Biological Materials (abm): Clones for DNAJC22 - Now 50% OFF >
  • * DNAJC22 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DNAJC22 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC22 Gene

Localization for DNAJC22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC22 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC22 gene
Compartment Confidence
plasma membrane 2
endoplasmic reticulum 2
extracellular 0
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DNAJC22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC22: view

Pathways & Interactions for DNAJC22 Gene

PathCards logo

SuperPathways for DNAJC22 Gene

No Data Available

Interacting Proteins for DNAJC22 Gene

Gene Ontology (GO) - Biological Process for DNAJC22 Gene


No data available for Pathways by source and SIGNOR curated interactions for DNAJC22 Gene

Drugs & Compounds for DNAJC22 Gene

No Compound Related Data Available

Transcripts for DNAJC22 Gene

mRNA/cDNA for DNAJC22 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(62) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for DNAJC22 Gene

DnaJ (Hsp40) homolog, subfamily C, member 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJC22

Clone Products

  • Applied Biological Materials (abm): Clones for DNAJC22 - Now 50% OFF >
  • * DNAJC22 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DNAJC22 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC22 Gene

No ASD Table

Relevant External Links for DNAJC22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNAJC22 Gene

This gene is overexpressed in Liver (x18.3), Colon - Transverse (x5.0), and Pancreas (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DNAJC22 Gene

NURSA nuclear receptor signaling pathways regulating expression of DNAJC22 Gene:


SOURCE GeneReport for Unigene cluster for DNAJC22 Gene:


Evidence on tissue expression from TISSUES for DNAJC22 Gene

  • Kidney(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with DNAJC22: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC22 Gene

Orthologs for DNAJC22 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNAJC22 35 34
  • 99.22 (n)
(Canis familiaris)
Mammalia DNAJC22 35 34
  • 89.09 (n)
(Bos Taurus)
Mammalia DNAJC22 35 34
  • 87.59 (n)
(Mus musculus)
Mammalia Dnajc22 17 35 34
  • 85.22 (n)
(Rattus norvegicus)
Mammalia Dnajc22 34
  • 84.85 (n)
(Ornithorhynchus anatinus)
Mammalia DNAJC22 35
  • 75 (a)
(Monodelphis domestica)
Mammalia DNAJC22 35
  • 68 (a)
(Anolis carolinensis)
Reptilia DNAJC22 35
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc22 34
  • 60.3 (n)
(Danio rerio)
Actinopterygii dnajc22 35 34
  • 57.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta wus 35 34
  • 45.64 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007138 34
  • 45.51 (n)
Species where no ortholog for DNAJC22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJC22 Gene

Gene Tree for DNAJC22 (if available)
Gene Tree for DNAJC22 (if available)
Evolutionary constrained regions (ECRs) for DNAJC22: view image

Paralogs for DNAJC22 Gene

No data available for Paralogs for DNAJC22 Gene

Variants for DNAJC22 Gene

Sequence variations from dbSNP and Humsavar for DNAJC22 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000174322 -- 49,346,525(+) C/G upstream_transcript_variant
rs1000204610 -- 49,347,873(+) A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000278259 -- 49,348,186(+) C/T intron_variant
rs1000796956 -- 49,351,339(+) C/A/T 3_prime_UTR_variant, coding_sequence_variant, missense_variant, synonymous_variant
rs1001275416 -- 49,347,298(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC22 Gene

Variant ID Type Subtype PubMed ID
dgv1497n100 CNV gain 25217958
nsv832405 CNV gain 17160897

Variation tolerance for DNAJC22 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJC22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC22 Gene

Disorders for DNAJC22 Gene

Additional Disease Information for DNAJC22

No disorders were found for DNAJC22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC22 Gene

Publications for DNAJC22 Gene

  1. Wurst is essential for airway clearance and respiratory-tube size control. (PMID: 17558392) Behr M … Hoch M (Nature cell biology 2007) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung ML … Jeang KT (The Journal of biological chemistry 2009) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for DNAJC22 Gene

Sources for DNAJC22 Gene

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