Aliases for DNAJC21 Gene
External Ids for DNAJC21 Gene
Previous GeneCards Identifiers for DNAJC21 Gene
This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the precursor 45S ribosomal RNA and may be involved in early nuclear ribosomal RNA biogenesis and maturation of the 60S ribosomal subunit. Mutations in this gene result in Bone marrow failure syndrome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2017]
GeneCards Summary for DNAJC21 Gene
DNAJC21 (DnaJ Heat Shock Protein Family (Hsp40) Member C21) is a Protein Coding gene. Diseases associated with DNAJC21 include Bone Marrow Failure Syndrome 3 and Pancytopenia. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is DNAJC18.
UniProtKB/Swiss-Prot Summary for DNAJC21 Gene
May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA.