DNAJC2 Gene (Protein Coding)

DnaJ Heat Shock Protein Family (Hsp40) Member C2

GC07M103312
GIFtS:
37
This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. Th... See more...

Aliases for DNAJC2 Gene

Aliases for DNAJC2 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C2 2 3 5
  • MPHOSPH11 2 3 4
  • MPP11 2 3 4
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 2 2 3
  • DnaJ Homolog Subfamily C Member 2 3 4
  • M-Phase Phosphoprotein 11 3 4
  • Zuotin-Related Factor 1 3 4
  • ZRF1 3 4
  • ZUO1 2 3
  • Zuotin Related Factor 1 2
  • DNAJC2 5
  • Zuotin 2

External Ids for DNAJC2 Gene

Previous HGNC Symbols for DNAJC2 Gene

  • ZRF1

Previous GeneCards Identifiers for DNAJC2 Gene

  • GC07M102741
  • GC07M102952
  • GC07M097315

Summaries for DNAJC2 Gene

Entrez Gene Summary for DNAJC2 Gene

  • This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for DNAJC2 Gene

DNAJC2 (DnaJ Heat Shock Protein Family (Hsp40) Member C2) is a Protein Coding gene. Diseases associated with DNAJC2 include Lynch Syndrome I. Among its related pathways are Cellular response to heat stress and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include histone binding. An important paralog of this gene is DNAJC17.

UniProtKB/Swiss-Prot Summary for DNAJC2 Gene

  • Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.

Gene Wiki entry for DNAJC2 Gene

Additional gene information for DNAJC2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DNAJC2 Gene

Genomics for DNAJC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for DNAJC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DNAJC2

Top Transcription factor binding sites by QIAGEN in the DNAJC2 gene promoter:
  • c-Myc
  • E47
  • Egr-2
  • Max
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2
  • SRF
  • SRF (504 AA)
  • Tal-1beta

Genomic Locations for DNAJC2 Gene

Genomic Locations for DNAJC2 Gene
chr7:103,312,289-103,344,873
(GRCh38/hg38)
Size:
32,585 bases
Orientation:
Minus strand
chr7:102,952,921-102,985,320
(GRCh37/hg19)
Size:
32,400 bases
Orientation:
Minus strand

Genomic View for DNAJC2 Gene

Genes around DNAJC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DNAJC2 Gene

Proteins for DNAJC2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DNAJC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99543-DNJC2_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 2
    Protein Accession:
    Q99543
    Secondary Accessions:
    • A4VCI0
    • Q9BVX1

    Protein attributes for DNAJC2 Gene

    Size:
    621 amino acids
    Molecular mass:
    71996 Da
    Quaternary structure:
    • Interacts (via ZRF1-UBD region) with ID1 (By similarity). Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
    SequenceCaution:
    • Sequence=AAI39752.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAA66913.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • Constitutes a myeloid leukemia-associated antigen and might be a target for leukemia T-cell therapy.

    Three dimensional structures from OCA and Proteopedia for DNAJC2 Gene

    Alternative splice isoforms for DNAJC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC2 Gene

Protein Expression for DNAJC2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DNAJC2 Gene

Other Protein References for DNAJC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for DNAJC2
  • Boster Bio Antibodies for DNAJC2

No data available for DME Specific Peptides for DNAJC2 Gene

Domains & Families for DNAJC2 Gene

Gene Families for DNAJC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for DNAJC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJC2 Gene

GenScript: Design optimal peptide antigens:
  • Zuotin-related factor 1 (DNJC2_HUMAN)
  • DNAJC2 protein (Q08AR5_HUMAN)
  • DNAJC2 protein (Q6P5S9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99543

UniProtKB/Swiss-Prot:

DNJC2_HUMAN :
  • The ZRF1-UBD region specifically recognizes and binds H2AK119ub. The ZRF1-UBD region is also involved in protein-protein interactions with other proteins, suggesting that it may be masked by some regulator, thereby preventing its association with H2AK119ub.
Domain:
  • The ZRF1-UBD region specifically recognizes and binds H2AK119ub. The ZRF1-UBD region is also involved in protein-protein interactions with other proteins, suggesting that it may be masked by some regulator, thereby preventing its association with H2AK119ub.
genes like me logo Genes that share domains with DNAJC2: view

Function for DNAJC2 Gene

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Molecular function for DNAJC2 Gene

UniProtKB/Swiss-Prot Function:
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.
UniProtKB/Swiss-Prot Induction:
Expression is repressed by CEBPA. Strongly overexpressed in leukemic cells.

Phenotypes From GWAS Catalog for DNAJC2 Gene

Gene Ontology (GO) - Molecular Function for DNAJC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IDA 21179169
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 21179169
GO:0030544 Hsp70 protein binding IPI 16002468
genes like me logo Genes that share ontologies with DNAJC2: view

Phenotypes for DNAJC2 Gene

GenomeRNAi human phenotypes for DNAJC2:
genes like me logo Genes that share phenotypes with DNAJC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC2 Gene

Localization for DNAJC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC2 Gene

Nucleus. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNAJC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 8885239
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 28416769
GO:0005737 cytoplasm IEA,IDA 8885239
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DNAJC2: view

Pathways & Interactions for DNAJC2 Gene

genes like me logo Genes that share pathways with DNAJC2: view

Pathways by source for DNAJC2 Gene

1 Cell Signaling Technology pathway for DNAJC2 Gene

Gene Ontology (GO) - Biological Process for DNAJC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006325 chromatin organization IEA --
GO:0045893 positive regulation of transcription, DNA-templated IDA 21179169
GO:0051083 'de novo' cotranslational protein folding TAS 16002468
GO:1900034 regulation of cellular response to heat TAS --
genes like me logo Genes that share ontologies with DNAJC2: view

No data available for SIGNOR curated interactions for DNAJC2 Gene

Drugs & Compounds for DNAJC2 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for DNAJC2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DNAJC2 Gene

4 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJC2

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3: - -
SP4: - -
SP5: -
SP6:

Relevant External Links for DNAJC2 Gene

GeneLoc Exon Structure for
DNAJC2

Expression for DNAJC2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJC2 Gene

mRNA expression in normal human tissues for DNAJC2 Gene
mRNA expression by BioGPS for DNAJC2 GenemRNA expression by GTEx for DNAJC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC2 Gene

This gene is overexpressed in Breast (11.6), Testis (9.3), Lymph node (7.1), and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DNAJC2 Gene



Protein tissue co-expression partners for DNAJC2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DNAJC2

SOURCE GeneReport for Unigene cluster for DNAJC2 Gene:

Hs.558476

mRNA Expression by UniProt/SwissProt for DNAJC2 Gene:

Q99543-DNJC2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for DNAJC2 Gene

  • Blood(4.4)
  • Nervous system(2.4)
  • Skin(2.3)
  • Eye(2.1)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with DNAJC2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC2 Gene

Orthologs for DNAJC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia DNAJC2 30 31
  • 99.73 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia DNAJC2 30 31
  • 94.86 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia DNAJC2 30 31
  • 94.63 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Dnajc2 30 17 31
  • 90.12 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia DNAJC2 31
  • 89 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Dnajc2 30
  • 88.84 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia DNAJC2 31
  • 83 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves DNAJC2 30 31
  • 82.23 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia DNAJC2 31
  • 88 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia dnajc2 30
  • 77.28 (n)
LOC394933 30
Zebrafish
(Danio rerio)
 Actinopterygii dnajc2 30 31
  • 68.42 (n)
 OneToOne
Dr.19599 30
Fruit Fly
(Drosophila melanogaster)
 Insecta CG10565 30 31
  • 52.08 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP007541 30
  • 49.65 (n)
Worm
(Caenorhabditis elegans)
 Secernentea dnj-11 30 31
  • 53.29 (n)
 OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes ZUO1 30 31 33
  • 50.18 (n)
 OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F03124g 30
  • 49.19 (n)
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_AGL339C 30
  • 47.09 (n)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT3G11450 30
  • 51.83 (n)
Rice
(Oryza sativa)
 Liliopsida Os04g0377932 30
  • 47.49 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes zuo1 30
  • 50.97 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.4829 31
  • 50 (a)
 OneToOne
Bread mold
(Neurospora crassa)
 Ascomycetes NCU03009 30
  • 46.41 (n)
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.2458 30
Species where no ortholog for DNAJC2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DNAJC2 Gene

ENSEMBL:
Gene Tree for DNAJC2 (if available)
TreeFam:
Gene Tree for DNAJC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DNAJC2: view image

Paralogs for DNAJC2 Gene

Paralogs for DNAJC2 Gene

(1) SIMAP similar genes for DNAJC2 Gene using alignment to 7 proteins:

  • DNJC2_HUMAN
  • C9IZ83_HUMAN
  • F2Z3H0_HUMAN
  • F2Z3N9_HUMAN
  • H7C3L7_HUMAN
  • Q08AR5_HUMAN
  • Q6P5S9_HUMAN

Pseudogenes.org Pseudogenes for DNAJC2 Gene

genes like me logo Genes that share paralogs with DNAJC2: view

Variants for DNAJC2 Gene

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Additional dbSNP identifiers (rs#s) for DNAJC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for DNAJC2 Gene

Variant ID Type Subtype PubMed ID
nsv1140832 CNV deletion 24896259
nsv5884 CNV insertion 18451855
nsv831084 CNV gain 17160897

Variation tolerance for DNAJC2 Gene

Residual Variation Intolerance Score: 22.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJC2 Gene

Human Gene Mutation Database (HGMD)
DNAJC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DNAJC2 Gene

Disorders for DNAJC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJC2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lynch syndrome i
  • colorectal cancer, hereditary nonpolyposis, type 1; hnpcc1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DNAJC2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with DNAJC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJC2 Gene

Publications for DNAJC2 Gene

  1. Identification of a novel peptide derived from the M-phase phosphoprotein 11 (MPP11) leukemic antigen recognized by human CD8+ cytotoxic T lymphocytes. (PMID: 20231810) Al Qudaihi G … Dermime S (Hematology/oncology and stem cell therapy 2010) 3 4 23
  2. The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex. (PMID: 16002468) Otto H … Rospert S (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 23
  3. Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia. (PMID: 12800198) Greiner J … Schmitt M (International journal of cancer 2003) 3 4 23
  4. Identification of novel M phase phosphoproteins by expression cloning. (PMID: 8885239) Matsumoto-Taniura N … Westendorf JM (Molecular biology of the cell 1996) 2 3 4
  5. Transcriptional activation of polycomb-repressed genes by ZRF1. (PMID: 21179169) Richly H … Di Croce L (Nature 2010) 3 4

ExternalLinks

View latest publications for DNAJC2 gene in Mastermind

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