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This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]
DNAJC2 (DnaJ Heat Shock Protein Family (Hsp40) Member C2) is a Protein Coding gene. Diseases associated with DNAJC2 include Lynch Syndrome I. Among its related pathways are Cellular response to heat stress and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include histone binding. An important paralog of this gene is DNAJC17.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003682 | chromatin binding | IDA | 21179169 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IPI | 21179169 |
GO:0030544 | Hsp70 protein binding | IPI | 16002468 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 8885239 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005730 | nucleolus | IDA | 28416769 |
GO:0005737 | cytoplasm | IEA,IDA | 8885239 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cellular response to heat stress | ||
2 | Translational Control | ||
3 | Cellular Senescence (REACTOME) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006260 | DNA replication | IEA | -- |
GO:0006325 | chromatin organization | IEA | -- |
GO:0045893 | positive regulation of transcription, DNA-templated | IDA | 21179169 |
GO:0051083 | 'de novo' cotranslational protein folding | TAS | 16002468 |
GO:1900034 | regulation of cellular response to heat | TAS | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DNAJC2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DNAJC2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DNAJC2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dnajc2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DNAJC2 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dnajc2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | DNAJC2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DNAJC2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DNAJC2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dnajc2 30 |
|
||
LOC394933 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | dnajc2 30 31 |
|
OneToOne | |
Dr.19599 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG10565 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007541 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | dnj-11 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ZUO1 30 31 33 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F03124g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGL339C 30 |
|
||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G11450 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os04g0377932 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | zuo1 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4829 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU03009 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2458 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
lynch syndrome i |
|
|