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Aliases for DNAJC18 Gene

Aliases for DNAJC18 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C18 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 18 2 3
  • DnaJ Homolog Subfamily C Member 18 3

External Ids for DNAJC18 Gene

Previous GeneCards Identifiers for DNAJC18 Gene

  • GC05M138776
  • GC05M133935

Summaries for DNAJC18 Gene

GeneCards Summary for DNAJC18 Gene

DNAJC18 (DnaJ Heat Shock Protein Family (Hsp40) Member C18) is a Protein Coding gene. An important paralog of this gene is DNAJB14.

Additional gene information for DNAJC18 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC18 Gene

Genomics for DNAJC18 Gene

GeneHancer (GH) Regulatory Elements for DNAJC18 Gene

Promoters and enhancers for DNAJC18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J139438 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 707.9 +5.1 5099 1.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF766 DNAJC18 MATR3 NRG2 PURA GC05P139409 GC05P139410 GC05P138946
GH05J139443 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 692.6 -1.1 -1111 4.6 PKNOX1 ATF1 KLF17 STAT5A BMI1 BATF KLF5 IRF4 ZNF366 SCRT2 DNAJC18 IGIP MATR3 LRRTM2 PURA MALINC1 GC05P139448 RNU5B-4P ENSG00000279686 GC05P138946
GH05J139381 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 41 +54.8 54773 15.5 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 SLC23A1 MZB1 DNAJC18 PURA PAIP2 SIL1 MATR3 PROB1 GC05P139382 SPATA24
GH05J139402 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 31 +40.6 40555 2.7 HDGF PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZBTB7B YY1 SPATA24 DNAJC18 ANKHD1 RPL7P19 PROB1 GC05P138946
GH05J139480 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 23.6 -37.6 -37557 3.3 HDGF PKNOX1 SMAD1 FEZF1 DMAP1 ZNF2 POLR2B ZNF766 ZNF213 KLF13 TMEM173 LOC101059986 ANKHD1 DNAJC18 PURA IGIP SMIM33 GC05M139466 GC05P138946
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJC18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJC18 gene promoter:
  • Olf-1
  • AhR
  • Arnt
  • c-Myb
  • HNF-4alpha1
  • FOXI1
  • HFH-3
  • Msx-1
  • Lmo2

Genomic Locations for DNAJC18 Gene

Genomic Locations for DNAJC18 Gene
35,904 bases
Minus strand
35,902 bases
Minus strand

Genomic View for DNAJC18 Gene

Genes around DNAJC18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC18 Gene

Proteins for DNAJC18 Gene

  • Protein details for DNAJC18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DnaJ homolog subfamily C member 18
    Protein Accession:

    Protein attributes for DNAJC18 Gene

    358 amino acids
    Molecular mass:
    41551 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DNAJC18 Gene

Post-translational modifications for DNAJC18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DNAJC18 Gene

Domains & Families for DNAJC18 Gene

Gene Families for DNAJC18 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DNAJC18 Gene

Suggested Antigen Peptide Sequences for DNAJC18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJC18: view

No data available for UniProtKB/Swiss-Prot for DNAJC18 Gene

Function for DNAJC18 Gene

Phenotypes From GWAS Catalog for DNAJC18 Gene

Phenotypes for DNAJC18 Gene

genes like me logo Genes that share phenotypes with DNAJC18: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC18 Gene

Localization for DNAJC18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC18 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC18 gene
Compartment Confidence
cytosol 4
mitochondrion 1
peroxisome 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNAJC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC18: view

Pathways & Interactions for DNAJC18 Gene

SuperPathways for DNAJC18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC18 Gene


No data available for Pathways by source and SIGNOR curated interactions for DNAJC18 Gene

Drugs & Compounds for DNAJC18 Gene

No Compound Related Data Available

Transcripts for DNAJC18 Gene

mRNA/cDNA for DNAJC18 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(117) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNAJC18 Gene

DnaJ (Hsp40) homolog, subfamily C, member 18:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC18 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP3: -
SP4: - -

Relevant External Links for DNAJC18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNAJC18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC18 Gene

This gene is overexpressed in Tlymphocyte (39.2), Monocytes (18.5), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DNAJC18 Gene

Protein tissue co-expression partners for DNAJC18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC18 Gene:


SOURCE GeneReport for Unigene cluster for DNAJC18 Gene:


Evidence on tissue expression from TISSUES for DNAJC18 Gene

  • Nervous system(4.5)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with DNAJC18: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC18 Gene

Orthologs for DNAJC18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNAJC18 34 33
  • 99.35 (n)
(Bos Taurus)
Mammalia DNAJC18 34 33
  • 93.48 (n)
(Canis familiaris)
Mammalia DNAJC18 34 33
  • 92.13 (n)
(Mus musculus)
Mammalia Dnajc18 16 34 33
  • 85.62 (n)
(Rattus norvegicus)
Mammalia Dnajc18 33
  • 84.28 (n)
(Monodelphis domestica)
Mammalia DNAJC18 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia DNAJC18 34
  • 68 (a)
(Gallus gallus)
Aves DNAJC18 34 33
  • 71.77 (n)
(Anolis carolinensis)
Reptilia DNAJC18 34
  • 68 (a)
(Danio rerio)
Actinopterygii dnajc18 34 33
  • 61.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3061 34
  • 32 (a)
CG30156 34
  • 22 (a)
(Caenorhabditis elegans)
Secernentea dnj-1 34
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HLJ1 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for DNAJC18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DNAJC18 Gene

Gene Tree for DNAJC18 (if available)
Gene Tree for DNAJC18 (if available)
Evolutionary constrained regions (ECRs) for DNAJC18: view image

Paralogs for DNAJC18 Gene

Paralogs for DNAJC18 Gene

(14) SIMAP similar genes for DNAJC18 Gene using alignment to 9 proteins:

  • D6RB03_HUMAN
  • D6RB44_HUMAN
  • H0Y9V6_HUMAN
  • H0YA78_HUMAN
genes like me logo Genes that share paralogs with DNAJC18: view

Variants for DNAJC18 Gene

Sequence variations from dbSNP and Humsavar for DNAJC18 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000092606 -- 139,437,068(-) G/T intron_variant
rs1000154802 -- 139,413,980(-) A/T 3_prime_UTR_variant
rs1000226115 -- 139,430,048(-) T/C intron_variant
rs1000235682 -- 139,434,704(-) T/A intron_variant
rs1000443009 -- 139,437,318(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC18 Gene

Variant ID Type Subtype PubMed ID
esv2762551 CNV gain 21179565
esv3570440 CNV loss 25503493
nsv472002 CNV novel sequence insertion 20440878
nsv474124 CNV novel sequence insertion 20440878
nsv519808 CNV loss 19592680

Variation tolerance for DNAJC18 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 21.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJC18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC18 Gene

Disorders for DNAJC18 Gene

Additional Disease Information for DNAJC18

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DNAJC18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC18 Gene

Publications for DNAJC18 Gene

  1. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  2. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 44 58
  3. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood HD … Lan Q (Respiratory medicine 2009) 3 44 58
  4. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PMID: 19240791) Graubert TA … Walter MJ (PloS one 2009) 3 44 58
  5. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood HD … Lan Q (Carcinogenesis 2008) 3 44 58

Products for DNAJC18 Gene

Sources for DNAJC18 Gene

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