Aliases for DNAJC17 Gene

Aliases for DNAJC17 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C17 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 17 2 3
  • DnaJ Homolog Subfamily C Member 17 3 4
  • FLJ10634 2
  • DNAJC17 5

External Ids for DNAJC17 Gene

Previous GeneCards Identifiers for DNAJC17 Gene

  • GC15M038848
  • GC15M041060
  • GC15M017908

Summaries for DNAJC17 Gene

GeneCards Summary for DNAJC17 Gene

DNAJC17 (DnaJ Heat Shock Protein Family (Hsp40) Member C17) is a Protein Coding gene. Diseases associated with DNAJC17 include Deafness, Autosomal Recessive 37 and Mirror Movements 1. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is DNAJC13.

UniProtKB/Swiss-Prot Summary for DNAJC17 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DNAJC17 Gene

Genomics for DNAJC17 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DNAJC17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJC17 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DNAJC17

Top Transcription factor binding sites by QIAGEN in the DNAJC17 gene promoter:
  • AhR
  • c-Myc
  • CP2
  • IRF-7A
  • Max1
  • Nkx2-5
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for DNAJC17 Gene

Latest Assembly
chr15:40,765,161-40,807,478
(GRCh38/hg38)
Size:
42,318 bases
Orientation:
Minus strand

Previous Assembly
chr15:41,057,359-41,099,671
(GRCh37/hg19 by Entrez Gene)
Size:
42,313 bases
Orientation:
Minus strand

chr15:41,060,067-41,099,675
(GRCh37/hg19 by Ensembl)
Size:
39,609 bases
Orientation:
Minus strand

Genomic View for DNAJC17 Gene

Genes around DNAJC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC17 Gene

Proteins for DNAJC17 Gene

  • Protein details for DNAJC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVM6-DJC17_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 17
    Protein Accession:
    Q9NVM6

    Protein attributes for DNAJC17 Gene

    Size:
    304 amino acids
    Molecular mass:
    34687 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DNAJC17 Gene

neXtProt entry for DNAJC17 Gene

Post-translational modifications for DNAJC17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DNAJC17 Gene

Domains & Families for DNAJC17 Gene

Gene Families for DNAJC17 Gene

Protein Domains for DNAJC17 Gene

InterPro:
Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)

Suggested Antigen Peptide Sequences for DNAJC17 Gene

GenScript: Design optimal peptide antigens:
  • DnaJ homolog subfamily C member 17 (DJC17_HUMAN)
genes like me logo Genes that share domains with DNAJC17: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DNAJC17 Gene

Function for DNAJC17 Gene

Molecular function for DNAJC17 Gene

UniProtKB/Swiss-Prot Function:
May negatively affect PAX8-induced thyroglobulin/TG transcription.

Phenotypes From GWAS Catalog for DNAJC17 Gene

Gene Ontology (GO) - Molecular Function for DNAJC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with DNAJC17: view
genes like me logo Genes that share phenotypes with DNAJC17: view

Animal Models for DNAJC17 Gene

MGI Knock Outs for DNAJC17:

Animal Models for research

  • Taconic Biosciences Mouse Models for DNAJC17

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJC17

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DNAJC17 Gene

Localization for DNAJC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC17 Gene

Cytoplasm. Nucleus. Note=Predominantly nuclear. {ECO:0000250 UniProtKB:D3ZSC8}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC17 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DNAJC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DNAJC17: view

Pathways & Interactions for DNAJC17 Gene

PathCards logo

SuperPathways for DNAJC17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with DNAJC17: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC17 Gene

Drugs & Compounds for DNAJC17 Gene

No Compound Related Data Available

Transcripts for DNAJC17 Gene

mRNA/cDNA for DNAJC17 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DNAJC17

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC17 Gene

No ASD Table

Relevant External Links for DNAJC17 Gene

GeneLoc Exon Structure for
DNAJC17

Expression for DNAJC17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJC17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC17 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.4) and Lung (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DNAJC17 Gene



Protein tissue co-expression partners for DNAJC17 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DNAJC17

SOURCE GeneReport for Unigene cluster for DNAJC17 Gene:

Hs.511069

Evidence on tissue expression from TISSUES for DNAJC17 Gene

  • Nervous system(4.4)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with DNAJC17: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC17 Gene

Orthologs for DNAJC17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC17 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DNAJC17 29 30
  • 99.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DNAJC17 29 30
  • 90.79 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DNAJC17 29 30
  • 89.14 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dnajc17 29 16 30
  • 88.12 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dnajc17 29
  • 87.13 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC17 30
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DNAJC17 29 30
  • 71.95 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DNAJC17 30
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dnajc17 29
  • 66.89 (n)
Str.10407 29
African clawed frog
(Xenopus laevis)
Amphibia MGC69064 29
Zebrafish
(Danio rerio)
Actinopterygii dnajc17 29 30
  • 65.2 (n)
OneToOne
zgc56091 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10984 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG17187 29 30
  • 54.79 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003825 29
  • 53.4 (n)
Worm
(Caenorhabditis elegans)
Secernentea dnj-22 30
  • 23 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G23590 29
  • 43.42 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0136800 29
  • 40.27 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 50 (a)
OneToOne
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cwf23 29
  • 45.2 (n)
Species where no ortholog for DNAJC17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DNAJC17 Gene

ENSEMBL:
Gene Tree for DNAJC17 (if available)
TreeFam:
Gene Tree for DNAJC17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DNAJC17: view image
Alliance of Genome Resources:
Additional Orthologs for DNAJC17

Paralogs for DNAJC17 Gene

(15) SIMAP similar genes for DNAJC17 Gene using alignment to 5 proteins:

  • DJC17_HUMAN
  • H0YK99_HUMAN
  • H0YLQ7_HUMAN
  • H0YLV4_HUMAN
  • S4R343_HUMAN

Pseudogenes.org Pseudogenes for DNAJC17 Gene

genes like me logo Genes that share paralogs with DNAJC17: view

Variants for DNAJC17 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DNAJC17 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DNAJC17 Gene

Variant ID Type Subtype PubMed ID
esv3636232 CNV loss 21293372
nsv1054764 CNV gain 25217958
nsv827306 CNV loss 20364138

Variation tolerance for DNAJC17 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJC17 Gene

Human Gene Mutation Database (HGMD)
DNAJC17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC17
Leiden Open Variation Database (LOVD)
DNAJC17

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DNAJC17 Gene

Disorders for DNAJC17 Gene

MalaCards: The human disease database

(5) MalaCards diseases for DNAJC17 Gene - From: COP

Disorder Aliases PubMed IDs
deafness, autosomal recessive 37
  • dfnb37
mirror movements 1
  • mrmv1
ileocolitis
  • iieocolitis
atrial septal defect 5
  • asd5
fundus dystrophy
  • retinal dystrophy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DNAJC17

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DNAJC17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJC17 Gene

Publications for DNAJC17 Gene

  1. DNAJC17 is localized in nuclear speckles and interacts with splicing machinery components. (PMID: 29773831) Pascarella A … Amendola E (Scientific reports 2018) 2 3
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for DNAJC17 Gene

Sources for DNAJC17 Gene