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Aliases for DNAJC17 Gene

Aliases for DNAJC17 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C17 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 17 2

External Ids for DNAJC17 Gene

Previous GeneCards Identifiers for DNAJC17 Gene

  • GC15M038848
  • GC15M041060
  • GC15M017908

Summaries for DNAJC17 Gene

GeneCards Summary for DNAJC17 Gene

DNAJC17 (DnaJ Heat Shock Protein Family (Hsp40) Member C17) is a Protein Coding gene. Diseases associated with DNAJC17 include Ileocolitis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is DNAJC12.

UniProtKB/Swiss-Prot for DNAJC17 Gene

  • May negatively affect PAX8-induced thyroglobulin/TG transcription.

Additional gene information for DNAJC17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC17 Gene

Genomics for DNAJC17 Gene

GeneHancer (GH) Regulatory Elements for DNAJC17 Gene

Promoters and enhancers for DNAJC17 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I040806 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.2 -162 2.5 HDGF PKNOX1 SMAD1 ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 E2F8 ZFYVE19 DNAJC17 GC15P040812 PIR31878 PIR45465 GC15P040865 GC15P040811 CHP1
GH15I040090 Promoter/Enhancer 3.3 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 68.8 +707.1 707120 18.8 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 BMF ENSG00000259211 DNAJC17 RAD51-AS1 BAHD1 CHST14 EIF2AK4 SRP14-AS1 ENSG00000259536 PLCB2
GH15I040762 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 41.1 +42.8 42829 4.3 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 E2F8 GCHFR MGA DNAJC17 ENSG00000259211 INO80 ZFYVE19 RAD51-AS1 CCDC32 BMF FAM92A1P1
GH15I041401 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 31.7 -595.0 -595023 1.8 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC NDUFAF1 DNAJC17 ENSG00000259211 INO80 GANC RAD51-AS1 LOC105370795 MGA CHST14 EHD4
GH15I040592 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 29 +213.1 213122 2.9 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D KNL1 TRS-GCT4-2 CCDC32 INO80 DNAJC17 ENSG00000259211 BMF RTF1 RMDN3 RAD51-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DNAJC17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJC17 gene promoter:

Genomic Locations for DNAJC17 Gene

Genomic Locations for DNAJC17 Gene
chr15:40,765,155-40,807,478
(GRCh38/hg38)
Size:
42,324 bases
Orientation:
Minus strand
chr15:41,060,067-41,099,676
(GRCh37/hg19)

Genomic View for DNAJC17 Gene

Genes around DNAJC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC17 Gene

Proteins for DNAJC17 Gene

  • Protein details for DNAJC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVM6-DJC17_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 17
    Protein Accession:
    Q9NVM6

    Protein attributes for DNAJC17 Gene

    Size:
    304 amino acids
    Molecular mass:
    34687 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DNAJC17 Gene

neXtProt entry for DNAJC17 Gene

Post-translational modifications for DNAJC17 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DNAJC17 Gene

Domains & Families for DNAJC17 Gene

Gene Families for DNAJC17 Gene

Suggested Antigen Peptide Sequences for DNAJC17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJC17: view

No data available for UniProtKB/Swiss-Prot for DNAJC17 Gene

Function for DNAJC17 Gene

Molecular function for DNAJC17 Gene

UniProtKB/Swiss-Prot Function:
May negatively affect PAX8-induced thyroglobulin/TG transcription.

Phenotypes From GWAS Catalog for DNAJC17 Gene

Gene Ontology (GO) - Molecular Function for DNAJC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with DNAJC17: view

Phenotypes for DNAJC17 Gene

genes like me logo Genes that share phenotypes with DNAJC17: view

Animal Models for DNAJC17 Gene

MGI Knock Outs for DNAJC17:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DNAJC17 Gene

Localization for DNAJC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC17 Gene

Cytoplasm. Nucleus. Note=Predominantly nuclear. {ECO:0000250 UniProtKB:D3ZSC8}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC17 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DNAJC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DNAJC17: view

Pathways & Interactions for DNAJC17 Gene

SuperPathways for DNAJC17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with DNAJC17: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC17 Gene

Drugs & Compounds for DNAJC17 Gene

No Compound Related Data Available

Transcripts for DNAJC17 Gene

Unigene Clusters for DNAJC17 Gene

DnaJ (Hsp40) homolog, subfamily C, member 17:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC17 Gene

No ASD Table

Relevant External Links for DNAJC17 Gene

GeneLoc Exon Structure for
DNAJC17
ECgene alternative splicing isoforms for
DNAJC17

Expression for DNAJC17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC17 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.4) and Lung (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC17 Gene



Protein tissue co-expression partners for DNAJC17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC17 Gene:

DNAJC17

SOURCE GeneReport for Unigene cluster for DNAJC17 Gene:

Hs.511069

Evidence on tissue expression from TISSUES for DNAJC17 Gene

  • Nervous system(4.3)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with DNAJC17: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC17 Gene

Orthologs for DNAJC17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC17 33 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia DNAJC17 33 34
  • 90.79 (n)
cow
(Bos Taurus)
Mammalia DNAJC17 33 34
  • 89.14 (n)
mouse
(Mus musculus)
Mammalia Dnajc17 33 16 34
  • 88.12 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc17 33
  • 87.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC17 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJC17 33 34
  • 71.95 (n)
lizard
(Anolis carolinensis)
Reptilia DNAJC17 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc17 33
  • 66.89 (n)
Str.10407 33
African clawed frog
(Xenopus laevis)
Amphibia MGC69064 33
zebrafish
(Danio rerio)
Actinopterygii dnajc17 33 34
  • 65.2 (n)
zgc56091 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10984 33
fruit fly
(Drosophila melanogaster)
Insecta CG17187 33 34
  • 54.79 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003825 33
  • 53.4 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-22 34
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G23590 33
  • 43.42 (n)
rice
(Oryza sativa)
Liliopsida Os03g0136800 33
  • 40.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cwf23 33
  • 45.2 (n)
Species where no ortholog for DNAJC17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC17 Gene

ENSEMBL:
Gene Tree for DNAJC17 (if available)
TreeFam:
Gene Tree for DNAJC17 (if available)

Paralogs for DNAJC17 Gene

Paralogs for DNAJC17 Gene

Pseudogenes.org Pseudogenes for DNAJC17 Gene

genes like me logo Genes that share paralogs with DNAJC17: view

Variants for DNAJC17 Gene

Sequence variations from dbSNP and Humsavar for DNAJC17 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000058877 -- 40,793,346(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000070858 -- 40,775,402(-) C/A/T intron_variant
rs1000083715 -- 40,793,738(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000177756 -- 40,795,160(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000210800 -- 40,771,256(-) GGGGGGG/GGGGGG/GGGGGGGG genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC17 Gene

Variant ID Type Subtype PubMed ID
nsv827306 CNV loss 20364138
nsv1054764 CNV gain 25217958
esv3636232 CNV loss 21293372

Variation tolerance for DNAJC17 Gene

Residual Variation Intolerance Score: 65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJC17 Gene

Human Gene Mutation Database (HGMD)
DNAJC17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC17 Gene

Disorders for DNAJC17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DNAJC17 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
ileocolitis
  • iieocolitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DNAJC17

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DNAJC17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DNAJC17 Gene

Publications for DNAJC17 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for DNAJC17 Gene

Sources for DNAJC17 Gene

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