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Aliases for DNAJC16 Gene

Aliases for DNAJC16 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C16 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 16 2
  • KIAA0962 4

External Ids for DNAJC16 Gene

Previous GeneCards Identifiers for DNAJC16 Gene

  • GC01P015599
  • GC01P015725
  • GC01P015853
  • GC01P014372

Summaries for DNAJC16 Gene

GeneCards Summary for DNAJC16 Gene

DNAJC16 (DnaJ Heat Shock Protein Family (Hsp40) Member C16) is a Protein Coding gene. An important paralog of this gene is DNAJC18.

Additional gene information for DNAJC16 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC16 Gene

Genomics for DNAJC16 Gene

GeneHancer (GH) Regulatory Elements for DNAJC16 Gene

Promoters and enhancers for DNAJC16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I015522 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.5 -1494 5.9 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 CASP9 DNAJC16 ENSG00000237938 SPEN AGMAT ZBTB17 RPL22P3 ARHGEF19 RPS16P1 GC01P015468
GH01I014994 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.1 -530.4 -530398 3.1 HDGF ATF1 ZNF493 ZFP64 ZNF121 ZNF766 ZNF213 ZNF302 KLF7 FOS SPEN ENSG00000237938 ZBTB17 RPS16P1 ENSG00000237301 TMEM51-AS1 DNAJC16 PIR50978 LOC105376758
GH01I015573 Enhancer 0.8 dbSUPER 10.3 +47.8 47775 2.4 FOXA2 ZFP64 RAD21 YY1 ZNF121 ZNF213 ZNF354C KLF7 ZNF214 ZNF654 SPEN ENSG00000237938 RPL22P3 FBXO42 RPS16P1 ZBTB17 CROCCP3 ENSG00000237301 LINC01772 SPATA21
GH01I015543 Enhancer 1.2 ENCODE dbSUPER 0.4 +17.0 16998 1 HDGF PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 POLR2B ZNF766 GATA2 GC01P015544 SCARNA21B AGMAT ENSG00000237938 ZBTB17 DNAJC16 GC01P015565 PIR45878
GH01I015583 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 0.2 +58.0 57971 1.9 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 ZNF143 RXRA AGMAT CASP9 PIR62159 DNAJC16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DNAJC16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJC16 gene promoter:

Genomic Locations for DNAJC16 Gene

Genomic Locations for DNAJC16 Gene
chr1:15,526,813-15,592,379
(GRCh38/hg38)
Size:
65,567 bases
Orientation:
Plus strand
chr1:15,853,308-15,918,874
(GRCh37/hg19)

Genomic View for DNAJC16 Gene

Genes around DNAJC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC16 Gene

Proteins for DNAJC16 Gene

  • Protein details for DNAJC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2G8-DJC16_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 16
    Protein Accession:
    Q9Y2G8
    Secondary Accessions:
    • Q68D57
    • Q86X32
    • Q8N5P4

    Protein attributes for DNAJC16 Gene

    Size:
    782 amino acids
    Molecular mass:
    90591 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76806.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DNAJC16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJC16 Gene

Post-translational modifications for DNAJC16 Gene

Other Protein References for DNAJC16 Gene

No data available for DME Specific Peptides for DNAJC16 Gene

Domains & Families for DNAJC16 Gene

Gene Families for DNAJC16 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJC16: view

No data available for UniProtKB/Swiss-Prot for DNAJC16 Gene

Function for DNAJC16 Gene

Phenotypes From GWAS Catalog for DNAJC16 Gene

genes like me logo Genes that share phenotypes with DNAJC16: view

Animal Models for DNAJC16 Gene

MGI Knock Outs for DNAJC16:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJC16 Gene

Localization for DNAJC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC16 Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC16 gene
Compartment Confidence
endoplasmic reticulum 3
cytosol 3
plasma membrane 1
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DNAJC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DNAJC16: view

Pathways & Interactions for DNAJC16 Gene

SuperPathways for DNAJC16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with DNAJC16: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC16 Gene

Drugs & Compounds for DNAJC16 Gene

No Compound Related Data Available

Transcripts for DNAJC16 Gene

Unigene Clusters for DNAJC16 Gene

DnaJ (Hsp40) homolog, subfamily C, member 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC16 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a ·
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:

ExUns: 16b · 16c ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -

Relevant External Links for DNAJC16 Gene

GeneLoc Exon Structure for
DNAJC16
ECgene alternative splicing isoforms for
DNAJC16

Expression for DNAJC16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC16 Gene

This gene is overexpressed in Cerebrospinal fluid (51.8) and Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC16 Gene



Protein tissue co-expression partners for DNAJC16 Gene

NURSA nuclear receptor signaling pathways regulating expression of DNAJC16 Gene:

DNAJC16

SOURCE GeneReport for Unigene cluster for DNAJC16 Gene:

Hs.655410

Evidence on tissue expression from TISSUES for DNAJC16 Gene

  • Nervous system(4.3)
  • Eye(4.1)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with DNAJC16: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC16 Gene

Orthologs for DNAJC16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC16 33 34
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia DNAJC16 33 34
  • 90.2 (n)
dog
(Canis familiaris)
Mammalia DNAJC16 33 34
  • 89.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 89 (a)
OneToMany
-- 34
  • 86 (a)
OneToMany
-- 34
  • 84 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia DNAJC16 34
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc16 33
  • 85.04 (n)
mouse
(Mus musculus)
Mammalia Dnajc16 33 16 34
  • 83.25 (n)
chicken
(Gallus gallus)
Aves DNAJC16 33 34
  • 73.19 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488071 33
  • 68.28 (n)
zebrafish
(Danio rerio)
Actinopterygii dnajc16 33
  • 61.42 (n)
DNAJC16 (1 of 2) 34
  • 60 (a)
OneToMany
DNAJC16 (2 of 2) 34
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG40178 33 34
  • 43.88 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001070 33
  • 43.75 (n)
worm
(Caenorhabditis elegans)
Secernentea dnj-8 33 34
  • 42.74 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HLJ1 34
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToOne
Species where no ortholog for DNAJC16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC16 Gene

ENSEMBL:
Gene Tree for DNAJC16 (if available)
TreeFam:
Gene Tree for DNAJC16 (if available)

Paralogs for DNAJC16 Gene

Paralogs for DNAJC16 Gene

(3) SIMAP similar genes for DNAJC16 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DNAJC16: view

Variants for DNAJC16 Gene

Sequence variations from dbSNP and Humsavar for DNAJC16 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000001607 -- 15,556,931(+) C/T intron_variant
rs1000054323 -- 15,530,911(+) C/T intron_variant
rs1000137812 -- 15,563,540(+) C/A intron_variant
rs1000182129 -- 15,549,553(+) G/A intron_variant
rs1000384207 -- 15,570,526(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC16 Gene

Variant ID Type Subtype PubMed ID
nsv833536 CNV loss 17160897

Variation tolerance for DNAJC16 Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJC16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC16 Gene

Disorders for DNAJC16 Gene

Additional Disease Information for DNAJC16

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DNAJC16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC16 Gene

Publications for DNAJC16 Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 44 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58

Products for DNAJC16 Gene

Sources for DNAJC16 Gene

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