Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNAJC14 Gene

Aliases for DNAJC14 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C14 2 3 5
  • Dopamine Receptor-Interacting Protein Of 78 KDa 3 4
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 14 2 3
  • DnaJ Protein Homolog 3 3 4
  • Human DnaJ Protein 3 3 4
  • DRIP78 3 4
  • HDj-3 3 4
  • HDJ3 3 4
  • Dopamine Receptor Interacting Protein 3
  • DnaJ Homolog Subfamily C Member 14 3
  • LYST-Interacting Protein LIP6 3
  • DNAJ 3
  • LIP6 3

External Ids for DNAJC14 Gene

Previous GeneCards Identifiers for DNAJC14 Gene

  • GC12M054439
  • GC12M054440
  • GC12M054501
  • GC12M056214
  • GC12M053253

Summaries for DNAJC14 Gene

GeneCards Summary for DNAJC14 Gene

DNAJC14 (DnaJ Heat Shock Protein Family (Hsp40) Member C14) is a Protein Coding gene. An important paralog of this gene is ENSG00000257390.

UniProtKB/Swiss-Prot for DNAJC14 Gene

  • Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.

Gene Wiki entry for DNAJC14 Gene

Additional gene information for DNAJC14 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC14 Gene

Genomics for DNAJC14 Gene

GeneHancer (GH) Regulatory Elements for DNAJC14 Gene

Promoters and enhancers for DNAJC14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I055827 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 583.8 +1.2 1204 4.7 MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC DNAJC14 TMEM198B GC12P055831 PIR58217 BAZ2A ENSG00000258317 ZC3H10 ENSG00000257740 PHC1P1 RN7SL809P
GH12I056220 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 98.2 -392.1 -392058 5.7 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 RNF41 NABP2 NEMP1 BAZ2A PAN2 DNAJC14 ANKRD52 PHC1P1 ZBTB39 RN7SL809P
GH12I055715 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 56.2 +112.2 112152 7.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 RDH5 BLOC1S1 PIR46127 PIR49113 BAZ2A DNAJC14 RN7SL809P TMEM198B PAN2 CDK2
GH12I056266 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 60.5 -436.4 -436370 2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 COQ10A GC12M056238 NEMP1 PAN2 BAZ2A PHC1P1 ANKRD52 DNAJC14 SMARCC2 RN7SL809P
GH12I056114 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 52.6 -287.5 -287500 6.8 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZC3H10 RPL41 ESYT1 ENSG00000258345 GC12M056121 PIR42205 BAZ2A NEMP1 RN7SL809P DNAJC14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DNAJC14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJC14 gene promoter:

Genomic Locations for DNAJC14 Gene

Genomic Locations for DNAJC14 Gene
chr12:55,820,960-55,830,824
(GRCh38/hg38)
Size:
9,865 bases
Orientation:
Minus strand
chr12:56,214,744-56,224,608
(GRCh37/hg19)

Genomic View for DNAJC14 Gene

Genes around DNAJC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC14 Gene

Proteins for DNAJC14 Gene

  • Protein details for DNAJC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6Y2X3-DJC14_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 14
    Protein Accession:
    Q6Y2X3
    Secondary Accessions:
    • A5YM67
    • Q17RY2
    • Q66K17
    • Q96N59
    • Q96T63

    Protein attributes for DNAJC14 Gene

    Size:
    702 amino acids
    Molecular mass:
    78569 Da
    Quaternary structure:
    • Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal domain.
    SequenceCaution:
    • Sequence=BAB71050.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DNAJC14 Gene

Post-translational modifications for DNAJC14 Gene

No Post-translational modifications

Other Protein References for DNAJC14 Gene

No data available for DME Specific Peptides for DNAJC14 Gene

Domains & Families for DNAJC14 Gene

Gene Families for DNAJC14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DNAJC14 Gene

Suggested Antigen Peptide Sequences for DNAJC14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJC14: view

No data available for UniProtKB/Swiss-Prot for DNAJC14 Gene

Function for DNAJC14 Gene

Molecular function for DNAJC14 Gene

UniProtKB/Swiss-Prot Function:
Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.

Phenotypes From GWAS Catalog for DNAJC14 Gene

genes like me logo Genes that share phenotypes with DNAJC14: view

Animal Models for DNAJC14 Gene

MGI Knock Outs for DNAJC14:

Animal Model Products

miRNA for DNAJC14 Gene

miRTarBase miRNAs that target DNAJC14

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJC14 Gene

Localization for DNAJC14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC14 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC14 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
nucleus 3
cytosol 3
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DNAJC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane HDA,IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with DNAJC14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DNAJC14 Gene

Pathways & Interactions for DNAJC14 Gene

SuperPathways for DNAJC14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with DNAJC14: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC14 Gene

Drugs & Compounds for DNAJC14 Gene

(1) Drugs for DNAJC14 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DNAJC14: view

Transcripts for DNAJC14 Gene

Unigene Clusters for DNAJC14 Gene

DnaJ (Hsp40) homolog, subfamily C, member 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC14 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1:
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:
SP7:

ExUns: 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for DNAJC14 Gene

GeneLoc Exon Structure for
DNAJC14
ECgene alternative splicing isoforms for
DNAJC14

Expression for DNAJC14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC14 Gene

Protein differential expression in normal tissues from HIPED for DNAJC14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.4), Placenta (21.5), CD8 Tcells (9.3), and Testis (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC14 Gene



Protein tissue co-expression partners for DNAJC14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC14 Gene:

DNAJC14

SOURCE GeneReport for Unigene cluster for DNAJC14 Gene:

Hs.709320

mRNA Expression by UniProt/SwissProt for DNAJC14 Gene:

Q6Y2X3-DJC14_HUMAN
Tissue specificity: Highly expressed in pancreas and selectively expressed in brain, lung, liver, skeletal muscle and kidney.

Evidence on tissue expression from TISSUES for DNAJC14 Gene

  • Nervous system(4.5)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with DNAJC14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC14 Gene

Orthologs for DNAJC14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNAJC14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC14 33 34
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia DNAJC14 33
  • 91.69 (n)
-- 34
  • 91 (a)
OneToMany
cow
(Bos Taurus)
Mammalia DNAJC14 33 34
  • 90.53 (n)
mouse
(Mus musculus)
Mammalia Dnajc14 33 16 34
  • 86.31 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc14 33
  • 86.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 79 (a)
OneToMany
LOC426418 33
  • 74.47 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc14 33
  • 58.06 (n)
zebrafish
(Danio rerio)
Actinopterygii DNAJC14 34
  • 71 (a)
OneToMany
LOC555824 33
  • 66.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14650 34
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dnj-5 34
  • 14 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HLJ1 34
  • 17 (a)
OneToMany
Species where no ortholog for DNAJC14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC14 Gene

ENSEMBL:
Gene Tree for DNAJC14 (if available)
TreeFam:
Gene Tree for DNAJC14 (if available)

Paralogs for DNAJC14 Gene

Paralogs for DNAJC14 Gene

genes like me logo Genes that share paralogs with DNAJC14: view

Variants for DNAJC14 Gene

Sequence variations from dbSNP and Humsavar for DNAJC14 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000070111 -- 55,826,304(-) G/A intron_variant
rs1000584101 -- 55,830,680(-) C/T upstream_transcript_variant
rs1000872070 -- 55,829,992(-) C/G/T upstream_transcript_variant
rs1000931554 -- 55,825,575(-) G/A/C/T intron_variant
rs1001283510 -- 55,829,526(-) G/A 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC14 Gene

Variant ID Type Subtype PubMed ID
nsv832423 CNV gain 17160897
esv2675015 CNV deletion 23128226

Variation tolerance for DNAJC14 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJC14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC14 Gene

Disorders for DNAJC14 Gene

Additional Disease Information for DNAJC14

No disorders were found for DNAJC14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC14 Gene

Publications for DNAJC14 Gene

  1. Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain. (PMID: 12768437) Chen J … Xie Y (Journal of human genetics 2003) 3 4 22 58
  2. Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. (PMID: 11331877) Bermak JC … Zhou QY (Nature cell biology 2001) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. (PMID: 12446598) Leclerc PC … Guillemette G (Endocrinology 2002) 3 22 58

Products for DNAJC14 Gene

Sources for DNAJC14 Gene

Content
Loading form....