Aliases for DNAJC14 Gene
Aliases for DNAJC14 Gene
External Ids for DNAJC14 Gene
- HGNC: 24581
- Entrez Gene: 85406
- Ensembl: ENSG00000135392
- OMIM: 606092
- UniProtKB: Q6Y2X3
Previous GeneCards Identifiers for DNAJC14 Gene
- GC12M054439
- GC12M054440
- GC12M054501
- GC12M056214
- GC12M053253
Summaries for DNAJC14 Gene
GeneCards Summary for DNAJC14 Gene
DNAJC14 (DnaJ Heat Shock Protein Family (Hsp40) Member C14) is a Protein Coding gene. An important paralog of this gene is ENSG00000257390.
UniProtKB/Swiss-Prot for DNAJC14 Gene
-
Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.
Additional gene information for DNAJC14 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC14 Gene
Genomics for DNAJC14 Gene
GeneHancer (GH) Regulatory Elements for DNAJC14 Gene
Promoters and enhancers for DNAJC14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DNAJC14 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DNAJC14 gene promoter:
Regulatory Element Products
Genomic Locations for DNAJC14 Gene
Genomic Locations for DNAJC14 Gene
- chr12:55,820,960-55,830,824
- (GRCh38/hg38)
- Size:
- 9,865 bases
- Orientation:
- Minus strand
- chr12:56,214,744-56,224,608
- (GRCh37/hg19)
Genomic View for DNAJC14 Gene
Genes around DNAJC14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.2 by Ensembl
- 12q13.2 by Entrez Gene
- 12q13.2 by HGNC
DNAJC14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DNAJC14 Gene
Proteins for DNAJC14 Gene
-
Protein details for DNAJC14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6Y2X3-DJC14_HUMAN
- Recommended name:
- DnaJ homolog subfamily C member 14
- Protein Accession:
- Q6Y2X3
- A5YM67
- Q17RY2
- Q66K17
- Q96N59
- Q96T63
Protein attributes for DNAJC14 Gene
- Size:
- 702 amino acids
- Molecular mass:
- 78569 Da
- Quaternary structure:
-
- Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal domain.
- SequenceCaution:
-
- Sequence=BAB71050.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for DNAJC14 Gene
Post-translational modifications for DNAJC14 Gene
No Post-translational modifications
Other Protein References for DNAJC14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for DNAJC14
- Invitrogen Antibodies for DNAJC14
- Search GeneTex for Antibodies for DNAJC14
Protein Products
-
OriGene Purified Proteins for DNAJC14
- Search Origene for MassSpec and Protein Over-expression Lysates for DNAJC14
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- Search GeneTex for Proteins for DNAJC14
Assay Products
No data available for DME Specific Peptides for DNAJC14 Gene
Domains & Families for DNAJC14 Gene
Gene Families for DNAJC14 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for DNAJC14 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DNAJC14 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for DNAJC14 Gene
Function for DNAJC14 Gene
Molecular function for DNAJC14 Gene
- UniProtKB/Swiss-Prot Function:
- Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.
Phenotypes From GWAS Catalog for DNAJC14 Gene
Phenotypes for DNAJC14 Gene
- MGI mutant phenotypes for DNAJC14:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DNAJC14:
Animal Models for DNAJC14 Gene
- MGI Knock Outs for DNAJC14:
-
- Dnajc14 tm1.1(KOMP)Vlcg
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for DNAJC14
-
-
ViGene Biosciences lentiviral particle packaged cDNA for DNAJC14 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for DNAJC14
- genomics-online: gRNA clones - Search results for 106 available DNAJC14 gene related products
- Overview of 106 available DNAJC14 gene related products
- Applied Biological Materials CRISPR for DNAJC14
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DNAJC14
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miRNA for DNAJC14 Gene
- miRTarBase miRNAs that target DNAJC14
miRNA Products
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Inhibitory RNA Products
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- Overview of 106 available DNAJC14 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DNAJC14 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for DNAJC14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DNAJC14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for DNAJC14
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DNAJC14
-
ViGene Biosciences adenoviral particle packaged cDNA for DNAJC14 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DNAJC14 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DNAJC14 gene
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJC14 Gene
Localization for DNAJC14 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DNAJC14 Gene
- Endoplasmic reticulum membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| nucleus | 3 |
| cytosol | 3 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0016020 | membrane | HDA,IDA | 19946888 |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0070062 | extracellular exosome | HDA,IDA | 23376485 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for DNAJC14 Gene
Pathways & Interactions for DNAJC14 Gene
No Data Available
Interacting Proteins for DNAJC14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for DNAJC14 Gene
Transcripts for DNAJC14 Gene
mRNA/cDNA for DNAJC14 Gene
- (1) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (543) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DNAJC14 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DNAJC14
- genomics-online: gRNA clones - Search results for 106 available DNAJC14 gene related products
- Overview of 106 available DNAJC14 gene related products
- Applied Biological Materials CRISPR for DNAJC14
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DNAJC14
- GenScript: Design CRISPR guide RNA sequences for DNAJC14
miRNA Products
- Search ViGene Biosciences for DNAJC14
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for DNAJC14
- Browse OriGene Inhibitory RNA Products For DNAJC14
- genomics-online: shRNA clones - Search results for 106 available DNAJC14 gene related products
- Overview of 106 available DNAJC14 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DNAJC14 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for DNAJC14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DNAJC14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for DNAJC14
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 24 |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: |
Expression for DNAJC14 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (29.4), Placenta (21.5), CD8 Tcells (9.3), and Testis (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNAJC14 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DNAJC14 Gene:
DNAJC14SOURCE GeneReport for Unigene cluster for DNAJC14 Gene:
Hs.709320mRNA Expression by UniProt/SwissProt for DNAJC14 Gene:
Q6Y2X3-DJC14_HUMAN
Tissue specificity:
Highly expressed in pancreas and selectively expressed in brain, lung, liver, skeletal muscle and kidney.
Evidence on tissue expression from TISSUES for DNAJC14 Gene
- Nervous system(4.5)
- Skin(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for DNAJC14
-
OriGene qPCR primer pairs for DNAJC14
- genomics-online: primer clones - Search results for 106 available DNAJC14 gene related products
- Overview of 106 available DNAJC14 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC14 Gene
Orthologs for DNAJC14 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DNAJC14 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | DNAJC14 33 |
|
||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | DNAJC14 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Dnajc14 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dnajc14 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| LOC426418 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dnajc14 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | DNAJC14 34 |
|
OneToMany | |
| LOC555824 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG14650 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | dnj-5 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HLJ1 34 |
|
OneToMany |
- Species where no ortholog for DNAJC14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for DNAJC14 Gene
Variants for DNAJC14 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000070111 | -- | 55,826,304(-) | G/A | intron_variant | |
| rs1000584101 | -- | 55,830,680(-) | C/T | upstream_transcript_variant | |
| rs1000872070 | -- | 55,829,992(-) | C/G/T | upstream_transcript_variant | |
| rs1000931554 | -- | 55,825,575(-) | G/A/C/T | intron_variant | |
| rs1001283510 | -- | 55,829,526(-) | G/A | 5_prime_UTR_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv832423 | CNV | gain | 17160897 |
| esv2675015 | CNV | deletion | 23128226 |
Residual Variation Intolerance Score:
23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.63;
31.33% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DNAJC14 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DNAJC14
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC14 Gene
Disorders for DNAJC14 Gene
Additional Disease Information for DNAJC14
No disorders were found for DNAJC14 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC14 Gene
Publications for DNAJC14 Gene
- Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain. (PMID: 12768437) Chen J … Xie Y (Journal of human genetics 2003) 3 4 22 58
- Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. (PMID: 11331877) Bermak JC … Zhou QY (Nature cell biology 2001) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. (PMID: 12446598) Leclerc PC … Guillemette G (Endocrinology 2002) 3 22 58
Products for DNAJC14 Gene
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- Invitrogen Antibodies for DNAJC14
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DNAJC14
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for DNAJC14
- Search GeneTex for Proteins for DNAJC14
- ViGene Biosciences adenoviral particle packaged cDNA for DNAJC14 gene
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- Overview of 106 available DNAJC14 gene related products
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- Overview of 106 available DNAJC14 gene related products
Sources for DNAJC14 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew