This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed... See more...

Aliases for DNAJB9 Gene

Aliases for DNAJB9 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member B9 2 3 5
  • Microvascular Endothelial Differentiation Gene 1 Protein 3 4
  • Endoplasmic Reticulum DNA J Domain-Containing Protein 4 3 4
  • DnaJ (Hsp40) Homolog, Subfamily B, Member 9 2 3
  • DnaJ Homolog Subfamily B Member 9 3 4
  • ER-Resident Protein ERdj4 3 4
  • ERdj4 3 4
  • MDG1 3 4
  • Endoplasmic Reticulum DnaJ Homolog 4 3
  • MSTP049 3
  • MST049 3
  • MDG-1 3
  • Mdg-1 4

External Ids for DNAJB9 Gene

Previous HGNC Symbols for DNAJB9 Gene

  • MDG1

Previous GeneCards Identifiers for DNAJB9 Gene

  • GC07P106694
  • GC07P107756
  • GC07P107770
  • GC07P107804
  • GC07P107997
  • GC07P108210
  • GC07P102578

Summaries for DNAJB9 Gene

Entrez Gene Summary for DNAJB9 Gene

  • This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from apoptosis. [provided by RefSeq, Dec 2010]

GeneCards Summary for DNAJB9 Gene

DNAJB9 (DnaJ Heat Shock Protein Family (Hsp40) Member B9) is a Protein Coding gene. Among its related pathways are Photodynamic therapy-induced unfolded protein response and Unfolded Protein Response (UPR). Gene Ontology (GO) annotations related to this gene include misfolded protein binding. An important paralog of this gene is DNAJB12.

UniProtKB/Swiss-Prot Summary for DNAJB9 Gene

  • Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity).

Gene Wiki entry for DNAJB9 Gene

Additional gene information for DNAJB9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DNAJB9 Gene

Genomics for DNAJB9 Gene

GeneHancer (GH) Regulatory Elements for DNAJB9 Gene

Promoters and enhancers for DNAJB9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J108567 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -0.1 -144 5.2 HNRNPK FOXK2 ZBTB40 ZNF217 EP300 TCF12 SIN3A MYC NRF1 USF1 THAP5 PNPLA8 DNAJB9 lnc-PNPLA8-2 RPL7P32 LAMB1 ENSG00000272854 ENSG00000273055 CBLL1 piR-31292-190
GH07J108523 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.2 -43.8 -43769 5.3 FOXK2 ZBTB40 ZNF217 EP300 SIN3A NRF1 POLR2G SP1 NCOR1 GTF2E2 PNPLA8 THAP5 ENSG00000272854 RPL7P32 DNAJB9 CBLL1 RF00017-6560 lnc-THAP5-1 U63785 lnc-PNPLA8-2
GH07J108413 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -151.2 -151244 10.2 EP300 TCF12 TEAD4 ZIC2 AFF1 RFX1 HES1 MEF2C EZH2 CTBP1 PNPLA8 THAP5 NRCAM DNAJB9 LAMB4 RF00017-6558
GH07J108452 Enhancer 0.9 Ensembl ENCODE dbSUPER 9.6 -117.8 -117751 2 CTCF REST EZH2 SMC3 FOS ZNF189 RAD21 GATA2 JUN ZNF24 THAP5 PNPLA8 DNAJB9 NRCAM RF00017-6558
GH07J108497 Enhancer 0.7 ENCODE 10.5 -72.4 -72433 0.2 CTCF REST TOE1 RAD21 TRIM22 ZNF830 TAF9B SMC3 TRIM25 ARNT DNAJB9 PNPLA8 THAP5 piR-61532-301 piR-59133 lnc-PNPLA8-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJB9 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DNAJB9

Top Transcription factor binding sites by QIAGEN in the DNAJB9 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • Nkx2-5
  • Pax-2
  • Pax-2a
  • POU2F1
  • POU2F1a

Genomic Locations for DNAJB9 Gene

Genomic Locations for DNAJB9 Gene
chr7:108,569,745-108,574,850
(GRCh38/hg38)
Size:
5,106 bases
Orientation:
Plus strand
chr7:108,210,012-108,215,294
(GRCh37/hg19)
Size:
5,283 bases
Orientation:
Plus strand

Genomic View for DNAJB9 Gene

Genes around DNAJB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJB9 Gene

Proteins for DNAJB9 Gene

  • Protein details for DNAJB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBS3-DNJB9_HUMAN
    Recommended name:
    DnaJ homolog subfamily B member 9
    Protein Accession:
    Q9UBS3

    Protein attributes for DNAJB9 Gene

    Size:
    223 amino acids
    Molecular mass:
    25518 Da
    Quaternary structure:
    • Interacts with HSPA5/BiP; interaction is direct (By similarity). Interacts with ERN1/IRE1 (via the luminal region) (By similarity). Interacts with DERL1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for DNAJB9 Gene

neXtProt entry for DNAJB9 Gene

Post-translational modifications for DNAJB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNAJB9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJB9 Gene

Domains & Families for DNAJB9 Gene

Gene Families for DNAJB9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DNAJB9 Gene

Suggested Antigen Peptide Sequences for DNAJB9 Gene

GenScript: Design optimal peptide antigens:
  • Microvascular endothelial differentiation gene 1 protein (DNJB9_HUMAN)
  • cDNA FLJ34885 fis, clone NT2NE2016608, highly similar to DnaJ homolog subfamily B member 9 (Q6FIF1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UBS3

UniProtKB/Swiss-Prot:

DNJB9_HUMAN :
  • The J domain stimulates the ATPase activity of HSPA5/BiP, while the divergent targeting domain is required for efficient substrate recognition by HSPA5/BiP. The divergent targeting domain specifically recognizes and binds to aggregation-prone sequences.
Domain:
  • The J domain stimulates the ATPase activity of HSPA5/BiP, while the divergent targeting domain is required for efficient substrate recognition by HSPA5/BiP. The divergent targeting domain specifically recognizes and binds to aggregation-prone sequences.
genes like me logo Genes that share domains with DNAJB9: view

Function for DNAJB9 Gene

Molecular function for DNAJB9 Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity).

Phenotypes From GWAS Catalog for DNAJB9 Gene

Gene Ontology (GO) - Molecular Function for DNAJB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19815549
GO:0030544 Hsp70 protein binding IEA --
GO:0051087 chaperone binding ISS,IEA --
GO:0051787 misfolded protein binding IDA 18400946
genes like me logo Genes that share ontologies with DNAJB9: view
genes like me logo Genes that share phenotypes with DNAJB9: view

Animal Model Products

CRISPR Products

miRNA for DNAJB9 Gene

miRTarBase miRNAs that target DNAJB9

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJB9 Gene

Localization for DNAJB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJB9 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJB9 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
extracellular 4
cytosol 3
cytoskeleton 2
mitochondrion 2
golgi apparatus 2
plasma membrane 1
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNAJB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus ISS,IEA --
GO:0005737 cytoplasm IEA,ISS --
GO:0005783 endoplasmic reticulum IDA,IEA 21231916
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with DNAJB9: view

Pathways & Interactions for DNAJB9 Gene

genes like me logo Genes that share pathways with DNAJB9: view

Pathways by source for DNAJB9 Gene

Gene Ontology (GO) - Biological Process for DNAJB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002377 immunoglobulin production ISS --
GO:0006986 response to unfolded protein IEA --
GO:0030183 B cell differentiation IEA,ISS --
GO:0030433 ubiquitin-dependent ERAD pathway IEA,IMP 18400946
GO:0034976 response to endoplasmic reticulum stress IEA,ISS --
genes like me logo Genes that share ontologies with DNAJB9: view

No data available for SIGNOR curated interactions for DNAJB9 Gene

Drugs & Compounds for DNAJB9 Gene

No Compound Related Data Available

Transcripts for DNAJB9 Gene

mRNA/cDNA for DNAJB9 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJB9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: - -
SP3:

Relevant External Links for DNAJB9 Gene

GeneLoc Exon Structure for
DNAJB9

Expression for DNAJB9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNAJB9 Gene

mRNA differential expression in normal tissues according to GTEx for DNAJB9 Gene

This gene is overexpressed in Liver (x4.8).

Protein differential expression in normal tissues from HIPED for DNAJB9 Gene

This gene is overexpressed in Liver (18.0), Testis (13.9), and Ovary (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DNAJB9 Gene



Protein tissue co-expression partners for DNAJB9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DNAJB9

SOURCE GeneReport for Unigene cluster for DNAJB9 Gene:

Hs.741182

mRNA Expression by UniProt/SwissProt for DNAJB9 Gene:

Q9UBS3-DNJB9_HUMAN
Tissue specificity: Widely expressed. Expressed at highest level in the liver, placenta and kidney (PubMed:11836248).

Evidence on tissue expression from TISSUES for DNAJB9 Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Heart(2.4)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with DNAJB9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJB9 Gene

Orthologs for DNAJB9 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJB9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJB9 31 30
  • 99.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJB9 31 30
  • 93.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJB9 31 30
  • 93.09 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajb9 17 31 30
  • 91.44 (n)
rat
(Rattus norvegicus)
Mammalia Dnajb9 30
  • 90.39 (n)
oppossum
(Monodelphis domestica)
Mammalia DNAJB9 31
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJB9 31
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJB9 31 30
  • 76.74 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJB9 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajb9 30
  • 72.85 (n)
zebrafish
(Danio rerio)
Actinopterygii dnajb9a 31 30
  • 69.33 (n)
OneToMany
dnajb9b 31
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7130 31
  • 27 (a)
OneToOne
Species where no ortholog for DNAJB9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNAJB9 Gene

ENSEMBL:
Gene Tree for DNAJB9 (if available)
TreeFam:
Gene Tree for DNAJB9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DNAJB9: view image

Paralogs for DNAJB9 Gene

(7) SIMAP similar genes for DNAJB9 Gene using alignment to 2 proteins:

  • DNJB9_HUMAN
  • Q6FIF1_HUMAN
genes like me logo Genes that share paralogs with DNAJB9: view

Variants for DNAJB9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DNAJB9 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs17155937 - p.Arg136His

Additional dbSNP identifiers (rs#s) for DNAJB9 Gene

Structural Variations from Database of Genomic Variants (DGV) for DNAJB9 Gene

Variant ID Type Subtype PubMed ID
esv3572052 CNV loss 25503493

Variation tolerance for DNAJB9 Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJB9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJB9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJB9 Gene

Disorders for DNAJB9 Gene

Additional Disease Information for DNAJB9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DNAJB9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJB9 Gene

Publications for DNAJB9 Gene

  1. ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. (PMID: 18400946) Dong M … Weaver TE (Molecular biology of the cell 2008) 3 4 23 54
  2. Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress. (PMID: 11836248) Shen Y … Hendershot LM (The Journal of biological chemistry 2002) 3 4 23 54
  3. HLA-B35 upregulates endothelin-1 and downregulates endothelial nitric oxide synthase via endoplasmic reticulum stress response in endothelial cells. (PMID: 20335527) Lenna S … Scorza R (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 23 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54

Products for DNAJB9 Gene

Sources for DNAJB9 Gene