Aliases for DNAJB9 Gene
- DnaJ Heat Shock Protein Family (Hsp40) Member B9 2 3 5
- Microvascular Endothelial Differentiation Gene 1 Protein 3 4
- Endoplasmic Reticulum DNA J Domain-Containing Protein 4 3 4
- DnaJ (Hsp40) Homolog, Subfamily B, Member 9 2 3
- DnaJ Homolog Subfamily B Member 9 3 4
- ER-Resident Protein ERdj4 3 4
- ERdj4 3 4
External Ids for DNAJB9 Gene
Previous HGNC Symbols for DNAJB9 Gene
Previous GeneCards Identifiers for DNAJB9 Gene
This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from apoptosis. [provided by RefSeq, Dec 2010]
GeneCards Summary for DNAJB9 Gene
DNAJB9 (DnaJ Heat Shock Protein Family (Hsp40) Member B9) is a Protein Coding gene. Diseases associated with DNAJB9 include Fibrillary Glomerulonephritis and Non-Gestational Choriocarcinoma. Among its related pathways are Photodynamic therapy-induced unfolded protein response and Unfolded Protein Response (UPR). Gene Ontology (GO) annotations related to this gene include misfolded protein binding. An important paralog of this gene is DNAJB5.
UniProtKB/Swiss-Prot Summary for DNAJB9 Gene
Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity).